Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Series D$10.6MNEXT Energy Technologies develops next-gen organic photovoltaic (OPV) solutions for vision and spandrel glass, creating energy-producing solar facades.
Series A$10.6MCooler Heads is the creator of Amma™, an FDA-cleared scalp cooling system that helps cancer patients reduce hair loss during chemotherapy. Amma delivers hospital-grade cold-cap therapy that’s simple, portable, and patient-first.
Series B$10.5MBlueNalu, Inc. develops cell-cultivated seafood, beginning with bluefin tuna toro—crafted with care and produced without fishing.
Cheehoo, an AI 3D-animation startup, was founded by a group of Hollywood veterans including Rideback co-CEOs Michael LoFaso and Jonathan Eirich alongside producer Dan Lin (Netflix's former head of film), and raised $10M led by Greycroft with Point72 Asset Management participating.
Digital Surgery Systems, Inc. is the legal name behind True Digital Surgery, a Goleta, CA maker of 3D robotic-assisted surgical microscopy systems that was fully acquired by German medical device company B. Braun SE in September 2025.
Series C$10.5MGenerate more event revenue with Events.com. Sell tickets online, promote your events, find sponsors, and grow your event business.
Seed$10.4MOrbital AI Edge Compute for Next-Gen Space Operations
Series A$10.4MAeroRx Therapeutics is developing potential best-in-class nebulized combination therapies to improve COPD treatment.