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Stunning view of La Jolla cliffs and luxurious homes along the San Diego coastline.
FROM A GILDED AGE RESORT TOWN TO A BIOTECH AND RESEARCH HUB

La Jolla

27
companies
$554.3M
total raised
Healthcare, B2B, Cancer
top industries

The breakdown

27 startups on file in La Jolla, spanning Healthcare, B2B, Cancer, 25 of 27 have disclosed funding, $554.3M combined, 7 at Seed stage, founding dates span 1954-2025.

A bit of history

Speculators Frank T. Botsford and George W. Heald began developing La Jolla as a seaside resort during the real estate boom of the 1880s, and a rail line and hotel by 1894 drew early vacationers. Philanthropist Ellen Browning Scripps arrived in 1896 and became the neighborhood's principal developer, commissioning landmark buildings and helping fund the Scripps Institution of Oceanography, founded in 1903, which later anchored the creation of UC San Diego. That research base has since grown into a cluster of institutions including the Salk Institute, Scripps Research, and the Sanford Burnham Prebys Medical Discovery Institute, making La Jolla one of the region's leading biotech and research centers.

Series C$79.0M
Synthorx
La Jolla, CA · Founded 1954 · 10001 employees

Synthetic biology company that created novel DNA base pairs and uses them to incorporate novel amino acids into proteins for potential therapeutics in areas of cancer and autoimmune disorders.

Series CCancer
$200.0M
Inhibrx, Inc.
La Jolla, CA

Anchored by our protein-engineering expertise and our proprietary single-domain antibody platform, we’ve developed a unique pipeline of therapeutic candidates.

Healthcare
Series A$99.0M
Enlaza Therapeutics, Inc.
La Jolla, CA · Founded 2020

Enlaza Therapeutics is pioneering the field of covalent biologics, developing a novel classes of protein therapeutics based on its proprietary War-Lock™ platform.

Series AHealthcare
Series B$27.1M
Alume Biosciences Inc
La Jolla, CA

Alume Biosciences is developing nerve illumination technology, specifically bevonescein (ALM-488), to help surgeons protect and preserve nerve function during surgery by making nerves glow.

Series BHealthcare
Sylke, Inc. hero photo
Series B$20.3M
Sylke, Inc.
La Jolla, CA · Founded 2023

SYLKE® Skin Closure is a sterile, single-use, silk fibroin mesh strip with a pressure-sensitive adhesive intended for topical skin closure and wound support. The device is used to hold together well-approximated skin edges of a wound, and to cover and protect the wound. Learn more at sylke.com.

Series BHealthcare
Seed$18.6M
Spinogenix, Inc.
La Jolla, CA

Spinogenix is pioneering first-in-class, investigational therapeutics that restore brain synapses to improve the lives of patients worldwide.

SeedHealthcare
Paulex Bio Inc. hero photo
Series B$18.5M
Paulex Bio Inc.
La Jolla, CA · Founded 2023

Paulex Bio stands at the threshold of what could be a transformative breakthrough for type 1 and type 2 diabetes: beta cell regeneration through an oral medicine designed to eliminate the root cause of diabetes.​

Series BHealthcare
Model Medicines, Inc. hero photo
Series A$15.7M
Model Medicines, Inc.
La Jolla, CA · Founded 2019

Model Medicines engineers first-in-class small molecules against biological choke points, using AI to advance pipeline-in-a-pill therapeutics across high-impact diseases.

Series AHealthcare
Seed$14.8M
Arialys Therapeutics, Inc.
La Jolla, CA · Founded 2021

We explore the immense therapeutic opportunities to help those bound by autoimmune neuropsychiatric diseases.

SeedHealthcare
Valora Therapeutics, Inc. hero photo
Seed$13.0M
Valora Therapeutics, Inc.
La Jolla, CA · Founded 2023

Valora Therapeutics is developing AbLec™ multispecific antibodies and T-Lec™ T cell engagers — antibody-engineering platforms that decoy the glyco-immune checkpoint to create best-in-class therapeutics for cancer and autoimmune disease.

SeedHealthcare
Events.com, Inc. hero photo
Series C$10.5M
Events.com, Inc.
La Jolla, CA · ~11-50 employees

Generate more event revenue with Events.com. Sell tickets online, promote your events, find sponsors, and grow your event business.

Series CB2B
Series A$10.4M
AeroRx Therapeutics, Inc.
La Jolla, CA · Founded 2024

AeroRx Therapeutics is developing potential best-in-class nebulized combination therapies to improve COPD treatment.

Series AHealthcare
$10.0M
GENOMIC LIFE, INC.
La Jolla, CA

Learn how Genomic Life enhances health and well-being through genetic screenings, early detection, personalized cancer navigation, and ongoing support. Optimize employee benefits and create a healthier workforce.

Healthcare
Series A$5.0M
Sarmal, Inc.
La Jolla, CA
Series AHealthcare
Seed$3.5M
RightDevice, Inc.
La Jolla, CA · Founded 2020

RightDevice was co-founded by George Kramb and Patrick Frank and later rebranded as PatientPartner, a platform connecting patients with medical device information and providers.

SeedB2B
$1.9M
Balboa Joint Ventures Consolidated, LLC
La Jolla, CA · Founded 2021
Healthcare
A28 Therapeutics, Inc. hero photo
Series A$1.9M
A28 Therapeutics, Inc.
La Jolla, CA · Founded 2021

A28 Therapeutics is a clinical stage biopharmaceutical company developing a novel platform technology to treat multiple cancer types

Series AB2B
$1.5M
Canter Wealth Holdco, LLC
La Jolla, CA
B2B
DEPTH Health, Inc. hero photo
Seed$1.0M
DEPTH Health, Inc.
La Jolla, CA · Founded 2024

Using Clinical Insights to Guide Patient Traffic Flow — DEPTH™ accelerates care velocity across the patient journey through Augmented Surveillance Intelligence.

SeedB2B
Impulse Medical, Inc. hero photo
Seed$950K
Impulse Medical, Inc.
La Jolla, CA · Founded 2023 · ~11-50 employees

Impulse Medical Technologies - A leading manufacturer and distributor of high-quality medical electrodes and diagnostic supplies. Parent company of The Electrode Store and TES Wholesale.

SeedHealthcare
Seed$800K
ViroMissile, Inc.
La Jolla, CA

ViroMissile is developing the world’s first truly intravenously-delivered viruses that target and kill tumors.

SeedB2B
TIGER HOSPITALITY FH HOLDINGS, LLC hero photo
$550K
TIGER HOSPITALITY FH HOLDINGS, LLC
La Jolla, CA · Founded 2024

TIGER HOSPITALITY - Elevating San Diego

Consumer
$175K
Lions Mate With Lions, Ltd Liability Co
La Jolla, CA · Founded 2025
B2B
Mortgage Collaborative LLC hero photo
$32K
Mortgage Collaborative LLC
La Jolla, CA

Join The Mortgage Collaborative — a leading mortgage lender and preferred partner network helping mortgage professionals grow through collaboration, resources, and industry expertise.

B2B
$28K
Busa Beverage Inc
La Jolla, CA · Founded 2022

Busa Beverage was conceptualized by the Busalacchi family, owners of the Barbusa restaurant in San Diego's Little Italy, and makes what it calls the first oat-milk bottled espresso martini.

B2B
Sarmal
La Jolla, CA

Sarmal is developing proprietary single molecule DNA sequencing technology and target detection technology for genomic detection.

Healthcare
FUNR
La Jolla, CA
B2B