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Aerial view looking east toward Santa Ana and Irvine, California
UC IRVINE RESEARCH SPINOUTS AND ORANGE COUNTY'S TECH CORRIDOR

Irvine

98
companies
$1.43B
total raised
B2B, Healthcare, Industrials
top industries
Photo: Joe Mabel · CC BY-SA 4.0

A bit of history

UC Irvine opened in 1965 as the intellectual anchor of a master-planned city built by the Irvine Company, and its research park became the seed for what's now called the Tech Coast. Three UCLA graduates started Silicon & Synapse out of a business park near campus in February 1991, working with about $10,000 each; it later became Blizzard Entertainment. Irvine's tech and biotech base has kept growing from there, anchored today by companies like Broadcom.

Series F$164.3M
ModRetro, Inc.
Irvine, CA · Founded 2023

ModRetro brings the best of the past to modern consumer electronics, for those who crave technology with a human soul.

Series FB2B
$123.1M
Bright Uro, Inc.
Irvine, CA · Founded 2021
Healthcare
Series C$100.4M
JenaValve Technology Inc
Irvine, CA

JenaValve's investors include Bain Capital Life Sciences and the Qatar Investment Authority.

Series CHealthcare
$100.0M
MOBIX LABS, INC
Irvine, CA · Founded 2021

Mobix Labs went public on the Nasdaq (MOBX) in December 2023 via a SPAC merger with Chavant Capital Acquisition Corp.

B2B
Series E$99.5M
Beta Bionics, Inc
Irvine, CA

No math. No dosing decisions. Just freedom to live.

Series EHealthcare
Series B$96.9M
PatientFi, Inc.
Irvine, CA

PatientFi was co-founded in 2017 by Todd Watts and Scott Jorgensen and received a growth equity investment from Questa Capital in 2024.

Series BB2B
Series B$90.0M
VERTIMASS, LLC
Irvine, CA

Vertimass, an Irvine-based renewable fuels company, is chaired by real estate investor Bill Shopoff and led by CEO Dr. Charles Wyman.

Series BB2B
Series C$56.4M
Syntiant Corp.
Irvine, CA

Backed by Microsoft's M12 fund, Intel Capital, and Robert Bosch Venture Capital, the edge-AI chipmaker filed an S-1 for an IPO in July 2026.

Series CB2B
$50.0M
AVAYNE LLC
Irvine, CA · Founded 2020
Industrials
Series E$50.0M
Eledon Pharmaceuticals, Inc.
Irvine, CA

Eledon Pharmaceuticals was co-founded and is led by CEO David-Alexandre Gros, a physician and serial biotech entrepreneur, with investors including BVF Partners, RA Capital Management, and Blue Owl Capital.

Series EHealthcare
$47.8M
Oncocyte Corp
Irvine, CA

Oncocyte is a publicly traded diagnostics company (Nasdaq: OCX) that later renamed itself Insight Molecular Diagnostics and relocated its headquarters to Nashville.

Healthcare
$42.0M
Restora Medical, Inc.
Irvine, CA · Founded 2023

Restora Medical was founded by Dr. Quan Ni, who previously co-founded Inspire Medical Systems (Nasdaq: INSP).

Healthcare
Series C$41.2M
Movandi Corp
Irvine, CA

Movandi was founded by siblings Maryam and Reza Rofougaran, recognized pioneers in RF/SoC design from their time at Broadcom, with backers including Sierra Ventures and Celesta Capital.

Series CB2B
Series B$27.5M
Smart Health Diagnostics Co
Irvine, CA
Series BHealthcare
$26.9M
GATC HEALTH CORP
Irvine, CA · Founded 2020
B2B
Series A$21.9M
Innova Vascular, Inc.
Irvine, CA

Innova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.

Series AB2B
$20.0M
PDS Equities, LLC
Irvine, CA · Founded 2021
B2B
Series B$16.4M
Mixed-Signal Devices Inc.
Irvine, CA

Irvine-based Mixed-Signal Devices was founded by Avi Madisetti (CEO) and Tommy Yu and has raised roughly $26.8M, with Kyocera Ventures among its investors.

Series BB2B
Series A$15.6M
Huupe Inc.
Irvine, CA · Founded 2020

huupe brings you the world’s first smart basketball hoop, providing NBA level workouts, on-demand training, live coaching, data tracking and more.

Series AB2B
Series A$15.0M
SWARM Engineering, Inc.
Irvine, CA

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.

Series AB2B
Series B$11.6M
THERAHEART INC.
Irvine, CA · Founded 2023

Founded by Wei Gan, Ph.D.; the cardiac device maker has raised over $11M, with Qiming Venture Partners among its investors.

Series BB2B
Series B$11.1M
Turion Space Corp.
Irvine, CA · Founded 2020

Accelerating humanity’s galactic destiny

Series BB2B
Series A$10.3M
Orbee, Inc.
Irvine, CA

Orbee is the automotive data platform that unifies every customer signal so dealerships can activate smarter audiences, run better campaigns, and close more deals.

Series AB2B
Series B$10.1M
Highlight Holding Inc.
Irvine, CA · Founded 2024

The collective brain for high-velocity teams. Join waitlist: highlightai.com

Series BB2B
Series A$9.2M
Permissionless Labs, Inc.
Irvine, CA · Founded 2021

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.

Series AB2B
Series A$8.2M
4600 NVDT LLC
Irvine, CA · Founded 2025
Series AB2B
$8.2M
CU DIRECT CORP
Irvine, CA

CU Direct Corp, founded in 1994 and now branded as Origence, is a credit union service organization (CUSO) collectively owned by 124 credit union shareholders rather than by venture investors.

B2B
Seed$7.9M
CELESTIAL THERAPEUTICS INC.
Irvine, CA · Founded 2019

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.

SeedHealthcare
Seed$7.2M
Tally Surgical, Inc.
Irvine, CA · Founded 2020

The Tally Surgical retained sponge prevention solution utilizes UHF RFID to simplify and speed an accurate count of surgical sponges and towels.

SeedHealthcare
Series H$6.7M
Autopilot Holdings Corp
Irvine, CA · Founded 2020

Autopilot was built by the team behind the viral 'Pelosi Tracker' and lets users copy politicians' and top traders' stock trades; co-founder Brian Schardt has said the app manages roughly $1.8B in tracked assets.

Series HB2B
Series A$6.6M
Petalfast Inc.
Irvine, CA · Founded 2020

Petalfast was founded by cannabis industry veterans Jason Vegotsky and Arun Kurichety and has raised funding from Merida Capital Holdings and family offices to build a sales/distribution network for California cannabis brands.

Series AB2B
$5.7M
IRA Sunshine Holdings, LLC
Irvine, CA · Founded 2026

Sunshine Holdings PLC is a diversified Sri Lankan conglomerate engaged in the healthcare, consumer goods, and agribusiness sectors in Sri Lanka.

B2B
Seed$5.6M
Boundless Devices, Inc.
Irvine, CA · Founded 2025

We partner with global industry leaders to craft and deliver groundbreaking consumer electronics and connected solutions.

SeedB2B
Series A$5.5M
Truvion Holdings
Irvine, CA · Founded 2023
Series AB2B
$5.4M
Core-Arms, LLC
Irvine, CA

A federally licensed (ATF FFL) firearms manufacturer/dealer based in Irvine, CA, with patents assigned to inventor David Roth.

Industrials
$5.4M
New Range Financial Intelligence, Inc.
Irvine, CA · Founded 2024

Comprehensive compliance platform for broker-dealers and fintechs. Automate CAT/CAIS reporting, best execution analysis, trade surveillance, corporate actions, and data reconciliation.

B2B
Series B$5.0M
Cochl Inc
Irvine, CA · Founded 2022

Official website of Cochl

Series BB2B
$5.0M
FRDM Collective LLC
Irvine, CA · Founded 2025

Co-founded and led by CEO Isaac Oswalt; it is a private-equity roll-up platform that acquires and consolidates short-term rental operators while letting the original operators retain equity.

B2B
Series B$5.0M
Aten Technology, Inc.
Irvine, CA
Series BB2B
Series D$5.0M
Toughbuilt Industries, Inc
Irvine, CA

Professional-Grade Sawhorses, Tool Pouches and Knee Pads for work by ToughBuilt. Strictly for construction workers and electricians who need the best for the job!

Series DB2B
Series A$4.9M
GoVyrl, Inc.
Irvine, CA
Series AB2B
Seed$4.6M
Simply Bread Co.
Irvine, CA · Founded 2022

Turn your bread into dough. The Simply Bread Oven and app help bakers at every stage bake more, sell more, and grow a thriving micro-bakery.

SeedB2B
$4.5M
Vesica Health, Inc.
Irvine, CA · Founded 2022

Norwegian medical device company Photocure ASA announced in 2026 it is acquiring Vesica Health, whose bladder-cancer diagnostic AssureMDx has received FDA Breakthrough Device Designation.

Healthcare
Seed$4.4M
CLEARFLOW, Inc
Irvine, CA

Founded in 2007 by cardiothoracic surgeon Dr. Edward Boyle and Paul Molloy to develop anti-occlusion surgical drainage devices; the Anaheim-based company's PleuraFlow system was later distributed exclusively in the US by Maquet Medical Systems.

SeedHealthcare
Series A$4.2M
Tenovi Co.
Irvine, CA · Founded 2021

Tenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.

Series AHealthcare
Pre-Seed$4.0M
SocialCrowd, Inc.
Irvine, CA · Founded 2022

SocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!

Pre-SeedB2B
Series A$3.3M
Laguna Tech USA, Inc.
Irvine, CA · Founded 2022

Laguna Tech USA is an Irvine-based transcatheter heart valve company led by CEO Gilbert Madrid; it has raised over $8M, including investment from MedTech Innovator.

Series AHealthcare
Seed$3.2M
Amble Activewear
Irvine, CA · Founded 2021

Shop Amble Clothing — premium coastal golf polos, hoodies, shorts, and active apparel for men. Designed for the course, the coast, and everywhere in between. Free shipping on orders $100+.

SeedB2B
Series B$3.0M
Toro Neurovascular, Inc.
Irvine, CA · Founded 2021
Series BB2B
Seed$3.0M
AgBlox, Inc.
Irvine, CA · Founded 2019
SeedB2B
Series A$3.0M
Telesair, Inc.
Irvine, CA

Telesair, Inc. is a non-invasive ventilation manufacturer. We enable respiratory care in any setting through high-flow oxygen generation and portability.

Series AB2B
Series A$2.7M
Impossible Kicks Holding Company, Inc.
Irvine, CA · Founded 2022

Founded in 2021 by sneaker reseller Wayne Mocadlo with his brother John Mocadlo as COO, Impossible Kicks grew into one of the largest sneaker and streetwear resale chains in the US and has raised funds via equity crowdfunding.

Series AConsumer
Series B$2.6M
VISEON, INC.
Irvine, CA

Experience Viseon's Advanced Digital Visualization CRANIALSPINALExperience Viseon's

Series BB2B
$2.5M
SREG LONG BEACH 2 LLC
Irvine, CA · Founded 2025
Real Estate and Construction
Series A$2.3M
Sensible Care Inc.
Irvine, CA · Founded 2022

Co-founded in 2017 by Paul Kim, an Army veteran, the teletherapy company raised a $13M Series A led by Volition Capital.

Series AHealthcare
Seed$2.2M
OpenWav Inc.
Irvine, CA · Founded 2026

Empowering Indie Artists to Connect, Grow, and Earn - OpenWav

SeedB2B
Series D$2.1M
Zuum Transportation Inc.
Irvine, CA

Zuum Transportation has raised roughly $12.6M in total funding, with backers including Estes Express Lines, Plug and Play Ventures, and SAIC.

Series DB2B
$2.0M
Sycamore Honey Partners IV LLC
Irvine, CA · Founded 2026
B2B
Series A$2.0M
BEDROCK SERVICING, INC.
Irvine, CA · Founded 2024

Bedrock Servicing provides a hybrid operating model for private credit lenders. We combine institutional-grade loan servicing with proprietary technology to automate complex asset management, ensure audit-readiness, and eliminate administrative friction.

Series AB2B
Seed$1.9M
TIG ORRIN LLC
Irvine, CA · Founded 2022
SeedReal Estate and Construction
Series A$1.5M
Allevion Therapeutics, Inc.
Irvine, CA

Discover Allevion Therapeutics’ Allevx™ Smart-Band, a wearable device designed to reduce movement-related disorders due to Essential Tremor.

Series AHealthcare
Series B$1.4M
Marwynn Holdings, Inc.
Irvine, CA · Founded 2024

Founded in February 2024 by CEO Yin Yan, it completed an IPO on the Nasdaq Capital Market (ticker MWYN) in March 2025.

Series BConsumer
Series E$1.4M
Apple iSports Group, Inc.
Irvine, CA

Trades publicly on the OTCQB market under the ticker AAPI, unrelated to Apple Inc. despite the similar name and ticker.

Series EB2B
Series A$1.4M
Bookitngo Corp
Irvine, CA · Founded 2021

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.

Series AB2B
Seed$1.3M
XOStem Biosciences Ltd.
Irvine, CA · Founded 2018

XOStem Biosciences' listed principals include UC Irvine professor Jonathan Lakey, who co-developed the Edmonton Protocol, the landmark pancreatic islet cell transplantation procedure for treating type 1 diabetes.

SeedB2B
Seed$1.2M
Calico Infrastructure Holdings LLC
Irvine, CA · Founded 2024

Calico Building Services is a leading nationwide provider of commercial janitorial, repair, maintenance and construction services.

SeedIndustrials
Seed$1.1M
Food Safety Systems LLC
Irvine, CA · Founded 2025

Founded in 2001 by Stacy Sagowitz, a former school food service director, to help school and food-service operators manage sanitation compliance.

SeedB2B
Seed$1.0M
i3 Specialty, Inc.
Irvine, CA · Founded 2026

A unified solution to measure risk, reduce downtime, and strengthen insurance outcomes.

SeedB2B
$1.0M
THUMB TECHNOLGIES, INC.
Irvine, CA · Founded 2020

Thumb Technologies, an Irvine, CA conversational-analytics startup, was co-founded by Jae Chung (previously at Amazon and Autodesk) and Daniel Kopeinigg.

B2B
Pre-Seed$1.0M
Fufu & Tommy LLC
Irvine, CA · Founded 2023
Pre-SeedConsumer
Series B$900K
Bluon, Inc.
Irvine, CA

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.

Series BB2B
$755K
FigPIN Collect Awesome Inc.
Irvine, CA

FiGPiNS are hand-crafted enamel character pins featuring a patented backer that serves as a pin clasp AND display stand! FiGPiN elevates collectible pins!

Consumer
Series A$750K
Dap Media, Inc.
Irvine, CA · Founded 2023
Series AB2B
$739K
WORLD TREE TECHNOLOGIES INC
Irvine, CA

World Tree grows Paulownia hardwood through regenerative forestry in partnership with farmers across the Americas.

B2B
Seed$655K
YOUATTEST
Irvine, CA · Founded 2018

YouAttest offers cloud based identity auditing solutions and management We Securely manage user access and ensure compliance with ease Get started today!

SeedB2B
Series A$500K
Dardo Studios, Inc.
Irvine, CA · Founded 2023

At Dardo Studios, we provide boutique solutions for comprehensive art creation, including concept art, 3D modeling, animation, VFX, and more. We also offer art direction, recruiting services, and expertise in structuring and managing art departments.

Series AB2B
Seed$375K
Bquest, Inc.
Irvine, CA · Founded 2023

Connect your clients to trusted aging care experts quickly and seamlessly with bQuest. Become their go-to lifeline during family crises through our easy, vetted referral platform.

SeedB2B
Series A$375K
TimeCap LLC
Irvine, CA · Founded 2020
Series AB2B
Series A$350K
Uscape Apparel LLC
Irvine, CA

Uscape Apparel was founded in 2013 by Alex Nowlin, growing out of a class project at Bucknell University into a collegiate and destination-retail apparel manufacturer.

Series AB2B
Series E$320K
Squeeze Software, Inc.
Irvine, CA · Founded 2023
Series EB2B
Series A$250K
Startup Coach AI Inc
Irvine, CA · Founded 2025
Series AB2B
Seed$87K
ONIT Sciences
Irvine, CA

ONIT Sciences, based in Irvine, brought on Eric Mathur, a globally recognized plant geneticist and molecular biologist, as its Chief Science Officer.

SeedIndustrials
Seed$85K
Ecotrak, LLC
Irvine, CA · Founded 2018

Facility Management Software designed to help businesses save time and money while providing real-time, actionable data.

SeedB2B
Series D$53K
Vincit California, Inc.
Irvine, CA

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

Series DB2B
Seed$50K
Essential HR Holdings LLC
Irvine, CA · Founded 2024

Essential HR Services is a team of experienced, professional Human Resources (HR) Consultants specializing in Labor Law Compliance, Employee Relations, HR Administration, Organizational Development, Training, Health and Wellness Programs, and Payroll. Our goal is to deliver quality service, with the utmost integrity.

SeedB2B
Seed$50K
Olobby Inc
Irvine, CA · Founded 2021
SeedB2B
Seed$35K
FIRSTPEEL INC.
Irvine, CA · Founded 2023

A better dating app, coming soon. Join the waitlist now.

SeedB2B
$20K
Scientia Capital Solutions, Inc.
Irvine, CA · Founded 2025

Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.

B2B
Seed$20K
Dyverg Brands, LLC
Irvine, CA · Founded 2023

Brands is focused on building our own portfolio—brands that align consumer desire with long-term health and wellness trends.

SeedIndustrials
$15K
StarCLS, Inc.
Irvine, CA · Founded 2025

StarCLS, Inc. is the parent entity behind StarQuiz, an AI-powered classroom assessment platform based in Irvine, CA, co-founded by brothers Alp Can Cizem (CEO) and Cem Cizem (COO).

B2B
Seed$468
Phythera Therapeutics Inc.
Irvine, CA · Founded 2021

Phythera Therapeutics, Inc. is a biotechnology company leveraging the power of natural compounds to modulate key biological pathways in cancer and tissue regeneration to improve human health.

SeedHealthcare
Boumarang Inc.
Irvine, CA · Founded 2024

Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.

B2B
FFR GROUP LLC
Irvine, CA
Fintech
Azurite Software Holdings, Inc.
Irvine, CA · Founded 2023
B2B
Eagle Mountain Data Inc
Irvine, CA · Founded 2025

An Irvine-based AI infrastructure/data-center developer building large-scale 'AI Factory' data halls; KDC Partnership acquired a stake in the company in April 2026.

B2B
Entelexo Biotherapeutics
Irvine, CA · Founded 2021 · 3 employees

Creating a New Class of Drugs to Address Incurable Autoimmune Diseases

Y CombinatorHealthcare
Vena Vitals
Irvine, CA · Founded 2020 · 9 employees

A small sticker that monitors blood pressure continuously

Y CombinatorHealthcare
Korso
Irvine, CA · Founded 2026 · 3 employees

The AI-native agency

Y CombinatorB2B
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