UC Irvine opened in 1965 as the intellectual anchor of a master-planned city built by the Irvine Company, and its research park became the seed for what's now called the Tech Coast. Three UCLA graduates started Silicon & Synapse out of a business park near campus in February 1991, working with about $10,000 each; it later became Blizzard Entertainment. Irvine's tech and biotech base has kept growing from there, anchored today by companies like Broadcom.

ModRetro brings the best of the past to modern consumer electronics, for those who crave technology with a human soul.
JenaValve's investors include Bain Capital Life Sciences and the Qatar Investment Authority.
Mobix Labs went public on the Nasdaq (MOBX) in December 2023 via a SPAC merger with Chavant Capital Acquisition Corp.

No math. No dosing decisions. Just freedom to live.

PatientFi was co-founded in 2017 by Todd Watts and Scott Jorgensen and received a growth equity investment from Questa Capital in 2024.
Vertimass, an Irvine-based renewable fuels company, is chaired by real estate investor Bill Shopoff and led by CEO Dr. Charles Wyman.
Backed by Microsoft's M12 fund, Intel Capital, and Robert Bosch Venture Capital, the edge-AI chipmaker filed an S-1 for an IPO in July 2026.

Eledon Pharmaceuticals was co-founded and is led by CEO David-Alexandre Gros, a physician and serial biotech entrepreneur, with investors including BVF Partners, RA Capital Management, and Blue Owl Capital.
Oncocyte is a publicly traded diagnostics company (Nasdaq: OCX) that later renamed itself Insight Molecular Diagnostics and relocated its headquarters to Nashville.
Restora Medical was founded by Dr. Quan Ni, who previously co-founded Inspire Medical Systems (Nasdaq: INSP).
Movandi was founded by siblings Maryam and Reza Rofougaran, recognized pioneers in RF/SoC design from their time at Broadcom, with backers including Sierra Ventures and Celesta Capital.

Innova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.
Irvine-based Mixed-Signal Devices was founded by Avi Madisetti (CEO) and Tommy Yu and has raised roughly $26.8M, with Kyocera Ventures among its investors.

huupe brings you the world’s first smart basketball hoop, providing NBA level workouts, on-demand training, live coaching, data tracking and more.

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.
Founded by Wei Gan, Ph.D.; the cardiac device maker has raised over $11M, with Qiming Venture Partners among its investors.

Accelerating humanity’s galactic destiny
Orbee is the automotive data platform that unifies every customer signal so dealerships can activate smarter audiences, run better campaigns, and close more deals.

The collective brain for high-velocity teams. Join waitlist: highlightai.com

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.
CU Direct Corp, founded in 1994 and now branded as Origence, is a credit union service organization (CUSO) collectively owned by 124 credit union shareholders rather than by venture investors.

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.
The Tally Surgical retained sponge prevention solution utilizes UHF RFID to simplify and speed an accurate count of surgical sponges and towels.
Autopilot was built by the team behind the viral 'Pelosi Tracker' and lets users copy politicians' and top traders' stock trades; co-founder Brian Schardt has said the app manages roughly $1.8B in tracked assets.
Petalfast was founded by cannabis industry veterans Jason Vegotsky and Arun Kurichety and has raised funding from Merida Capital Holdings and family offices to build a sales/distribution network for California cannabis brands.

Sunshine Holdings PLC is a diversified Sri Lankan conglomerate engaged in the healthcare, consumer goods, and agribusiness sectors in Sri Lanka.
We partner with global industry leaders to craft and deliver groundbreaking consumer electronics and connected solutions.
A federally licensed (ATF FFL) firearms manufacturer/dealer based in Irvine, CA, with patents assigned to inventor David Roth.

Comprehensive compliance platform for broker-dealers and fintechs. Automate CAT/CAIS reporting, best execution analysis, trade surveillance, corporate actions, and data reconciliation.

Official website of Cochl
Co-founded and led by CEO Isaac Oswalt; it is a private-equity roll-up platform that acquires and consolidates short-term rental operators while letting the original operators retain equity.
Professional-Grade Sawhorses, Tool Pouches and Knee Pads for work by ToughBuilt. Strictly for construction workers and electricians who need the best for the job!

Turn your bread into dough. The Simply Bread Oven and app help bakers at every stage bake more, sell more, and grow a thriving micro-bakery.

Norwegian medical device company Photocure ASA announced in 2026 it is acquiring Vesica Health, whose bladder-cancer diagnostic AssureMDx has received FDA Breakthrough Device Designation.
Founded in 2007 by cardiothoracic surgeon Dr. Edward Boyle and Paul Molloy to develop anti-occlusion surgical drainage devices; the Anaheim-based company's PleuraFlow system was later distributed exclusively in the US by Maquet Medical Systems.

Tenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.

SocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!

Laguna Tech USA is an Irvine-based transcatheter heart valve company led by CEO Gilbert Madrid; it has raised over $8M, including investment from MedTech Innovator.

Shop Amble Clothing — premium coastal golf polos, hoodies, shorts, and active apparel for men. Designed for the course, the coast, and everywhere in between. Free shipping on orders $100+.

Telesair, Inc. is a non-invasive ventilation manufacturer. We enable respiratory care in any setting through high-flow oxygen generation and portability.
Founded in 2021 by sneaker reseller Wayne Mocadlo with his brother John Mocadlo as COO, Impossible Kicks grew into one of the largest sneaker and streetwear resale chains in the US and has raised funds via equity crowdfunding.

Experience Viseon's Advanced Digital Visualization CRANIALSPINALExperience Viseon's
Co-founded in 2017 by Paul Kim, an Army veteran, the teletherapy company raised a $13M Series A led by Volition Capital.

Empowering Indie Artists to Connect, Grow, and Earn - OpenWav
Zuum Transportation has raised roughly $12.6M in total funding, with backers including Estes Express Lines, Plug and Play Ventures, and SAIC.

Bedrock Servicing provides a hybrid operating model for private credit lenders. We combine institutional-grade loan servicing with proprietary technology to automate complex asset management, ensure audit-readiness, and eliminate administrative friction.
Discover Allevion Therapeutics’ Allevx™ Smart-Band, a wearable device designed to reduce movement-related disorders due to Essential Tremor.
Founded in February 2024 by CEO Yin Yan, it completed an IPO on the Nasdaq Capital Market (ticker MWYN) in March 2025.
Trades publicly on the OTCQB market under the ticker AAPI, unrelated to Apple Inc. despite the similar name and ticker.

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.
XOStem Biosciences' listed principals include UC Irvine professor Jonathan Lakey, who co-developed the Edmonton Protocol, the landmark pancreatic islet cell transplantation procedure for treating type 1 diabetes.

Calico Building Services is a leading nationwide provider of commercial janitorial, repair, maintenance and construction services.
Founded in 2001 by Stacy Sagowitz, a former school food service director, to help school and food-service operators manage sanitation compliance.

A unified solution to measure risk, reduce downtime, and strengthen insurance outcomes.
Thumb Technologies, an Irvine, CA conversational-analytics startup, was co-founded by Jae Chung (previously at Amazon and Autodesk) and Daniel Kopeinigg.

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.
FiGPiNS are hand-crafted enamel character pins featuring a patented backer that serves as a pin clasp AND display stand! FiGPiN elevates collectible pins!

World Tree grows Paulownia hardwood through regenerative forestry in partnership with farmers across the Americas.
YouAttest offers cloud based identity auditing solutions and management We Securely manage user access and ensure compliance with ease Get started today!

At Dardo Studios, we provide boutique solutions for comprehensive art creation, including concept art, 3D modeling, animation, VFX, and more. We also offer art direction, recruiting services, and expertise in structuring and managing art departments.

Connect your clients to trusted aging care experts quickly and seamlessly with bQuest. Become their go-to lifeline during family crises through our easy, vetted referral platform.
Uscape Apparel was founded in 2013 by Alex Nowlin, growing out of a class project at Bucknell University into a collegiate and destination-retail apparel manufacturer.
ONIT Sciences, based in Irvine, brought on Eric Mathur, a globally recognized plant geneticist and molecular biologist, as its Chief Science Officer.

Facility Management Software designed to help businesses save time and money while providing real-time, actionable data.

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

Essential HR Services is a team of experienced, professional Human Resources (HR) Consultants specializing in Labor Law Compliance, Employee Relations, HR Administration, Organizational Development, Training, Health and Wellness Programs, and Payroll. Our goal is to deliver quality service, with the utmost integrity.
A better dating app, coming soon. Join the waitlist now.

Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.
Brands is focused on building our own portfolio—brands that align consumer desire with long-term health and wellness trends.
StarCLS, Inc. is the parent entity behind StarQuiz, an AI-powered classroom assessment platform based in Irvine, CA, co-founded by brothers Alp Can Cizem (CEO) and Cem Cizem (COO).
Phythera Therapeutics, Inc. is a biotechnology company leveraging the power of natural compounds to modulate key biological pathways in cancer and tissue regeneration to improve human health.
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Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.
An Irvine-based AI infrastructure/data-center developer building large-scale 'AI Factory' data halls; KDC Partnership acquired a stake in the company in April 2026.

Creating a New Class of Drugs to Address Incurable Autoimmune Diseases

A small sticker that monitors blood pressure continuously

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