B2B startups in Irvine. Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.

ModRetro brings the best of the past to modern consumer electronics, for those who crave technology with a human soul.
Mobix Labs went public on the Nasdaq (MOBX) in December 2023 via a SPAC merger with Chavant Capital Acquisition Corp.

PatientFi was co-founded in 2017 by Todd Watts and Scott Jorgensen and received a growth equity investment from Questa Capital in 2024.
Vertimass, an Irvine-based renewable fuels company, is chaired by real estate investor Bill Shopoff and led by CEO Dr. Charles Wyman.
Backed by Microsoft's M12 fund, Intel Capital, and Robert Bosch Venture Capital, the edge-AI chipmaker filed an S-1 for an IPO in July 2026.
Movandi was founded by siblings Maryam and Reza Rofougaran, recognized pioneers in RF/SoC design from their time at Broadcom, with backers including Sierra Ventures and Celesta Capital.
Innova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.
Irvine-based Mixed-Signal Devices was founded by Avi Madisetti (CEO) and Tommy Yu and has raised roughly $26.8M, with Kyocera Ventures among its investors.

huupe brings you the world’s first smart basketball hoop, providing NBA level workouts, on-demand training, live coaching, data tracking and more.

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.
Founded by Wei Gan, Ph.D.; the cardiac device maker has raised over $11M, with Qiming Venture Partners among its investors.

Accelerating humanity’s galactic destiny
Orbee is the automotive data platform that unifies every customer signal so dealerships can activate smarter audiences, run better campaigns, and close more deals.

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Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.
CU Direct Corp, founded in 1994 and now branded as Origence, is a credit union service organization (CUSO) collectively owned by 124 credit union shareholders rather than by venture investors.
Autopilot was built by the team behind the viral 'Pelosi Tracker' and lets users copy politicians' and top traders' stock trades; co-founder Brian Schardt has said the app manages roughly $1.8B in tracked assets.
Petalfast was founded by cannabis industry veterans Jason Vegotsky and Arun Kurichety and has raised funding from Merida Capital Holdings and family offices to build a sales/distribution network for California cannabis brands.

Sunshine Holdings PLC is a diversified Sri Lankan conglomerate engaged in the healthcare, consumer goods, and agribusiness sectors in Sri Lanka.
We partner with global industry leaders to craft and deliver groundbreaking consumer electronics and connected solutions.

Comprehensive compliance platform for broker-dealers and fintechs. Automate CAT/CAIS reporting, best execution analysis, trade surveillance, corporate actions, and data reconciliation.

Official website of Cochl
Co-founded and led by CEO Isaac Oswalt; it is a private-equity roll-up platform that acquires and consolidates short-term rental operators while letting the original operators retain equity.
Professional-Grade Sawhorses, Tool Pouches and Knee Pads for work by ToughBuilt. Strictly for construction workers and electricians who need the best for the job!

Turn your bread into dough. The Simply Bread Oven and app help bakers at every stage bake more, sell more, and grow a thriving micro-bakery.

SocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!

Shop Amble Clothing — premium coastal golf polos, hoodies, shorts, and active apparel for men. Designed for the course, the coast, and everywhere in between. Free shipping on orders $100+.

Telesair, Inc. is a non-invasive ventilation manufacturer. We enable respiratory care in any setting through high-flow oxygen generation and portability.

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Zuum Transportation has raised roughly $12.6M in total funding, with backers including Estes Express Lines, Plug and Play Ventures, and SAIC.

Bedrock Servicing provides a hybrid operating model for private credit lenders. We combine institutional-grade loan servicing with proprietary technology to automate complex asset management, ensure audit-readiness, and eliminate administrative friction.
Trades publicly on the OTCQB market under the ticker AAPI, unrelated to Apple Inc. despite the similar name and ticker.

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.
XOStem Biosciences' listed principals include UC Irvine professor Jonathan Lakey, who co-developed the Edmonton Protocol, the landmark pancreatic islet cell transplantation procedure for treating type 1 diabetes.
Founded in 2001 by Stacy Sagowitz, a former school food service director, to help school and food-service operators manage sanitation compliance.

A unified solution to measure risk, reduce downtime, and strengthen insurance outcomes.
Thumb Technologies, an Irvine, CA conversational-analytics startup, was co-founded by Jae Chung (previously at Amazon and Autodesk) and Daniel Kopeinigg.

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.

World Tree grows Paulownia hardwood through regenerative forestry in partnership with farmers across the Americas.
YouAttest offers cloud based identity auditing solutions and management We Securely manage user access and ensure compliance with ease Get started today!

At Dardo Studios, we provide boutique solutions for comprehensive art creation, including concept art, 3D modeling, animation, VFX, and more. We also offer art direction, recruiting services, and expertise in structuring and managing art departments.

Connect your clients to trusted aging care experts quickly and seamlessly with bQuest. Become their go-to lifeline during family crises through our easy, vetted referral platform.
Uscape Apparel was founded in 2013 by Alex Nowlin, growing out of a class project at Bucknell University into a collegiate and destination-retail apparel manufacturer.

Facility Management Software designed to help businesses save time and money while providing real-time, actionable data.

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

Essential HR Services is a team of experienced, professional Human Resources (HR) Consultants specializing in Labor Law Compliance, Employee Relations, HR Administration, Organizational Development, Training, Health and Wellness Programs, and Payroll. Our goal is to deliver quality service, with the utmost integrity.
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Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.
StarCLS, Inc. is the parent entity behind StarQuiz, an AI-powered classroom assessment platform based in Irvine, CA, co-founded by brothers Alp Can Cizem (CEO) and Cem Cizem (COO).
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Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.
An Irvine-based AI infrastructure/data-center developer building large-scale 'AI Factory' data halls; KDC Partnership acquired a stake in the company in April 2026.

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