Southern California's
Startup Directory
Every VC-backed and bootstrapped startup founded in Los Angeles, Orange County, San Diego, the Inland Empire, and Ventura — company profiles, funding rounds, and the investors and accelerators actually writing checks in the region, not a national list with a few SoCal names mixed in.
SeedStaxiom provides diligence-grade accounting for startups — bookkeeping, tax prep, and capital strategy, with an AI-assisted R&D tax credit engine reviewed by EY-trained CPAs. Founded by the team behind Ardius, the R&D tax credit company Gusto acquired in 2021.
Pre-Seed$4.0MSocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Specialized pelvic floor and women's health physical therapy.
Series B$19.0MAmpaire is a Long Beach; California-based aerospace and electric aircraft company; founded in 2016. It raised a $19M Series B in August 2026; from investors including Gaingels; Tribe Capital and Starb
Series B$50.0MKhartis Therapeutics is a San Diego biotechnology company developing oral small-molecule medicines targeting clinically validated immunology pathways. Its lead program is an oral; selective IGF-1R inh
Series B$37.8MAmplifica is a San Diego clinical-stage biopharmaceutical company developing injectable treatments for hair loss. Rather than slowing loss; its approach works on the signalling molecules that govern t
Series B$31.0M
Series B$335.0MCrystalys Therapeutics is a San Diego clinical-stage biotechnology company developing treatments for gout; a disease it argues remains badly served despite being common. Its lead candidate is in pivot
Series B$90.0MSenra Systems is a California-based B2B startup automating wire harness manufacturing for aerospace; defense; and industrial sectors. Founded by ex-SpaceX engineers Jordan Black and Benjamin Shanahan;
Series B$207.0MWugen is an off-the-shelf Cell Therapies for Cancer founded by Matthew Cooper; Todd Fehniger; Melissa Berrien-Elliott and John DiPersio.
EXPLORE TOP CITIES
WHAT SOUTHERN CALIFORNIA BUILDS
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Pharmaceutical & Biopharma
Drug developers and biopharma platforms, concentrated in San Diego's Torrey Pines corridor and the LA biotech cluster. Searched as "pharmaceutical companies in San Diego / Orange County" more than any other industry phrase in our Search Console data.
Biotechnology & Life Sciences
The life-science research base behind San Diego's and Los Angeles's biotech reputations: platforms, tools, diagnostics and therapeutics spun out of UCSD, Scripps, Caltech and UCLA.
Software & SaaS
Software companies across the region, from Irvine's enterprise SaaS bench to Santa Monica's consumer apps: the broadest category here after AI, and the one people search for by city.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.