Biotechnology & Life Sciences startups in Southern California

Biotech making affordable corrective eye-care products for physicians.

AI platform that generates code-compliant architectural, structural, and MEP construction documents from sketches, CAD files, or plain-language descriptions.

Khartis Therapeutics is a San Diego biotechnology company developing oral small-molecule medicines targeting clinically validated immunology pathways. Its lead program is an oral; selective IGF-1R inh

Amplifica is a San Diego clinical-stage biopharmaceutical company developing injectable treatments for hair loss. Rather than slowing loss; its approach works on the signalling molecules that govern t

Crystalys Therapeutics is a San Diego clinical-stage biotechnology company developing treatments for gout; a disease it argues remains badly served despite being common. Its lead candidate is in pivot

Wugen is an off-the-shelf Cell Therapies for Cancer founded by Matthew Cooper; Todd Fehniger; Melissa Berrien-Elliott and John DiPersio.

Evotrex is electrifying the RV by designing its products as mobile energy systems combining onboard power generation, energy storage, and intelligent energy management.

Founded in 2017; Onchilles Pharma is a drug-discovery and development company pioneering first-in-class cytotoxic therapies that selectively kill cancer cells while preserving and activating immune fu

Rarity PBC is a public benefit biotechnology company developing gene therapies for rare diseases; with an explicit focus on affordability and access.

Wolf Games builds AI-generated daily games that publishers and brands embed in their own sites: murder mysteries and puzzles generated from a customer's trending articles; refreshed every day; with st

Salt AI sells Salt OS; an AI workflow orchestration platform for regulated industries; life sciences; financial services; energy and government; that runs inside a customer's own infrastructure and is

Quilter uses physics-driven AI to automate printed circuit board layout; generating and validating board designs without manual routing.

Divergent designs; prints and assembles complex metal structures on what it calls the Divergent Adaptive Production System (DAPS); an end-to-end line that runs from AI-driven generative design through

DEBUT BIOTECHNOLOGY; INC. is a Carlsbad; California-based company founded in 2019.

Arnatar Therapeutics develops RNA medicines from a platform it calls DARGER; which pairs highly active siRNA for silencing a gene with ACT-UP1; an antisense technology that does the opposite and incre

Actio Biosciences is a biotechnology company pioneering precision medicine by developing genetically targeted therapies for both rare and common diseases. Leveraging advanced genomics; Actio aims to t

Parallel Bio is a Los Angeles; California-based biotechnology company developing curative immunotherapies and related technologies.

Liminal is a brand-new user-generated content game for narrative action role-playing games.

Uthana operates as a 3D character animation studio that uses generative AI.

Inari is a biotechnology and agricultural technology company

Pleno is a biotechnology company that aims speeding up disease diagnosis and treatment.

Terray Therapeutics is a Los Angeles-based biotechnology company that combines ultra-high throughput experimentation; generative AI; biology; medicinal chemistry; automation; and nanotechnology to exp

Plai /plā/ (verb) : To engage in artificial intelligence for the purpose of enjoyment and recreation.

Alterome Therapeutics; Inc. is an oncology Treatments founded in 2021 by Eric Murphy.

Abintus Bio; Inc. is a San Diego-based; preclinical stage gene therapy company focused on the discovery and development of a portfolio of product candidates that are designed to directly reprogram imm

Molecular Assemblies; Inc. is an enzymatic DNA synthesis technology founded in 2013 by Curt Becker; Bill Efcavitch and William Efcavitch.

ImmunoVec; Inc. is a Santa Monica; California-based company founded in 2019.

AvantStay is a premier next-generation hospitality platform for short-term rentals (STRs).

A biotechnology company focused on the discovery and development of next-generation therapeutics.

Shoreline Biosciences; Inc. is a Cell-Based Immunotherapies; founded in 2020. It has raised $229M across 4 funding rounds; most recently a $140M in November 2021; from investors including Janus Capita

Clarify Medical is a developer of a handheld medical device used to treat psoriasis; eczema; and vitiligo .

MosaicML is a San Francisco-based company offering a generative AI platform for enterprises to build their own AI systems.

Genomatica; which trades as Geno; is a San Diego industrial biotechnology company founded in 2000 by Christophe Schilling. It engineers micro-organisms and the bioprocesses around them so that widely

Kumquat Biosciences is a San Diego-based biotechnology company focused on the research and development of oncology medicines.

Nanocellect biomedical is a life science tools company manufacturing cell sorters using proprietary technology.

Element Biosciences is a genetic analysis tools.

ViaCyte is a biotechnology company using stem cells to create pancreatic beta cell precursors for treating diabetes.

Operator of a biotechnology company intended to improve outcomes for people with cancer. The company offers a pipeline against validated oncology targets to deliver radioisotopes that emit alpha parti

Biosplice Therapeutics is a clinical-stage biotechnology company developing lorecivivint; an injectable small-molecule CLK/DYRK-family inhibitor for knee osteoarthritis.

Fortis Therapeutics is a San Diego; CA-based immuno-oncology biotech company

Neurelis Inc. is a private specialty pharmaceutical company based in San Diego; California; US; providing treatment options for epilepsy and central nervous system disorders.

Iridia is a DNA researching and developing company.

Truvian Sciences is a San Diego-based company developing automated; benchtop diagnostic systems founded in 2015.

Genalyte is an American medical analytics and diagnostics company.

IconOVir Bio is an oncolytic Virus Therapy.

Locanabio is a San Diego; California-based biotechnology company developing RNA-targeting gene therapies.

Libra Therapeutics is a small Molecules for Neurodegenerative Indications founded in 2019.

Sun Genomics is a company developing personalized probiotics founded in 2016 by Sunny Jain.

AirMap is a California-based drone industry company improving low-altitude-airspace infrastructure to help drone operators fly safely and legally.

GPB Scientific is an automation of Cell Therapy Manufacturing.

PROGENITY; INC is a provider of specialized genetic testing services.

Hocomo Hemp is an agricultural company that specializes in genetics; seedling; growing; harvesting; and final production and distribution.

Omniome is a San Diego-based company.

Empirico Inc. comprises of biologists; physicians; chemists; data scientists and drug developers whose focus is on transforming patients' lives with innovative therapies.

SGI-DNA is a synthetic biology company that is headquartered in La Jolla; California and was founded by Craig Venter in 2013.

Cold Genesys is a privately-held; immunotherapy based biopharmaceutical company

PetDesk sells practice software to veterinary clinics. It covers client communication and reminders; online booking; an integrated phone system; AI-generated clinical notes and marketing; and is aimed

Roswell Biotechnologies is a molecular electronics company that transforms DNA sequencing with new molecular electronics sequencing platform.

Samumed is a biotechnology company focused on the medical research and development for tissue-level regeneration.

Pfenex is a San Diego-based company founded in 2009.