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Pharmaceutical & Biopharma startups in Southern California

Drug developers and biopharma platforms, concentrated in San Diego's Torrey Pines corridor and the LA biotech cluster. Searched as "pharmaceutical companies in San Diego / Orange County" more than any other industry phrase in our Search Console data.

122
companies
$8.95B
total raised
21
cities

Companies

LighthouseAI hero photo
Series A$8.0M
LighthouseAI
Los Angeles, CA

Pharma and medical-device compliance software plus licensing consulting.

Series AB2B
$36.0M
AppliedVR, Inc.
Van Nuys, CA

Develops FDA-authorized virtual reality therapeutics, including RelieVRx (formerly EaseVRx), a prescription VR program for chronic lower back pain.

Healthcare
Daré Bioscience
San Diego, CA · Founded 2015

Daré Bioscience (Nasdaq: DARE) is a San Diego-based biopharmaceutical company developing and commercializing therapies for women's reproductive and sexual health, an area of medicine it argues has been chronically underfunded relative to its size.

Healthcare
Triangle hero photo
Triangle
Pasadena, CA

Aggregates medical records from doctors, clinics, hospitals, labs, and pharmacies into one shared patient workspace.

Healthcare
Series B$50.0M
Khartis Therapeutics
San Diego, CA · Founded 2024

Khartis Therapeutics is a San Diego biotechnology company developing oral small-molecule medicines targeting clinically validated immunology pathways. Its lead program is an oral; selective IGF-1R inh

Series BImmunology
Series B$37.8M
Amplifica
San Diego, CA · Founded 2021

Amplifica is a San Diego clinical-stage biopharmaceutical company developing injectable treatments for hair loss. Rather than slowing loss; its approach works on the signalling molecules that govern t

Series BBiotechnology
Series B$335.0M
Crystalys Therapeutics
San Diego, CA · Founded 2025 · 31 employees

Crystalys Therapeutics is a San Diego clinical-stage biotechnology company developing treatments for gout; a disease it argues remains badly served despite being common. Its lead candidate is in pivot

Series BTherapeutics
Series B$207.0M
Wugen
San Diego, CA · 64 employees

Wugen is an off-the-shelf Cell Therapies for Cancer founded by Matthew Cooper; Todd Fehniger; Melissa Berrien-Elliott and John DiPersio.

Series BCAR T-Cell therapy
Series A$32.7M
Onchilles Pharma
San Diego, CA · Founded 2017 · 10 employees

Founded in 2017; Onchilles Pharma is a drug-discovery and development company pioneering first-in-class cytotoxic therapies that selectively kill cancer cells while preserving and activating immune fu

Series ABiotechnology
Series A$52.0M
Arnatar Therapeutics
San Diego, CA · Founded 2022 · 20 employees

Arnatar Therapeutics develops RNA medicines from a platform it calls DARGER; which pairs highly active siRNA for silencing a gene with ACT-UP1; an antisense technology that does the opposite and incre

Series ARNA-based and RNA-targeted therapeutics
Series A$5.0M
Entos Pharmaceuticals Inc.
San Diego, CA · Founded 2016 · 23 employees

Entos Pharmaceuticals develops nucleic acid-based therapies using its proprietary Fusogenix drug delivery system.

Series ADrug development
Seed$44.0M
Lomond Therapeutics
San Diego, CA · 31 employees

Lomond Therapeutics creates pharmacological platforms that target escape mutations.

SeedArtificial Intelligence (AI)
Series A$10.0M
Dyania Health
Los Angeles, CA · 31 employees

Dyania Health develops a research platform for pharma companies and hospital systems.

Series AHealth technology
Series B$180.0M
Terray Therapeutics
Pasadena, CA · Founded 2018 · 50 employees

Terray Therapeutics is a Los Angeles-based biotechnology company that combines ultra-high throughput experimentation; generative AI; biology; medicinal chemistry; automation; and nanotechnology to exp

Series BBiotechnology
Series C$312.5M
Escient Pharmaceuticals
San Diego, CA · Founded 2018 · 31 employees

Escient Pharmaceuticals is a GPCR-targeted Drugs founded in 2018.

Series CTechnology
Series A$99.0M
Alterome Therapeutics, Inc.
San Diego, CA · Founded 2021

Alterome Therapeutics; Inc. is an oncology Treatments founded in 2021 by Eric Murphy.

Series ABiotechnology
$15.7M
Abintus Bio, Inc.
San Diego, CA · Founded 2020 · 31 employees

Abintus Bio; Inc. is a San Diego-based; preclinical stage gene therapy company focused on the discovery and development of a portfolio of product candidates that are designed to directly reprogram imm

CAR T-Cell therapy
Series A$87.7M
1859
San Diego, CA · Founded 2019 · 126 employees

A biotechnology company focused on the discovery and development of next-generation therapeutics.

Series AArtificial Intelligence (AI)
$229.0M
Shoreline Biosciences, Inc.
San Diego, CA · Founded 2020 · 126 employees

Shoreline Biosciences; Inc. is a Cell-Based Immunotherapies; founded in 2020. It has raised $229M across 4 funding rounds; most recently a $140M in November 2021; from investors including Janus Capita

Cell therapy
$125.9M
Kumquat Biosciences Inc
San Diego, CA · Founded 2018 · 80 employees

Kumquat Biosciences is a San Diego-based biotechnology company focused on the research and development of oncology medicines.

Therapeutics
Series B$140.6M
Aristea Therapeutics
San Diego, CA · Founded 2018

Aristea Therapeutics is a small Molecules founded in 2018.

Series BEngineering
Series C$258.0M
RayzeBio
San Diego, CA · 51 employees

Operator of a biotechnology company intended to improve outcomes for people with cancer. The company offers a pipeline against validated oncology targets to deliver radioisotopes that emit alpha parti

Series CBiomedical engineering
$100.0M
BioTheryX
San Diego, CA · Founded 2008 · 31 employees

BioTheryX is a small Molecules founded in 2008.

Engineering
Series B$40.0M
Phanes Therapeutics
San Diego, CA

Phanes Therapeutics is a treatments for solid tumors and eye diseases.

Series BBiomedical engineering
Series D$799.0M
Biosplice Therapeutics
San Diego, CA · Founded 2008 · 30 employees

Biosplice Therapeutics is a clinical-stage biotechnology company developing lorecivivint; an injectable small-molecule CLK/DYRK-family inhibitor for knee osteoarthritis.

Series DBiotechnology
Series A$58.0M
Fortis Therapeutics
San Diego, CA · Founded 2016 · 31 employees

Fortis Therapeutics is a San Diego; CA-based immuno-oncology biotech company

Series ABiomedical engineering
Series D$114.0M
Neurelis Inc
San Diego, CA · Founded 2007 · 126 employees

Neurelis Inc. is a private specialty pharmaceutical company based in San Diego; California; US; providing treatment options for epilepsy and central nervous system disorders.

Series DBiotechnology
$100.0M
DTx Pharma, Inc.
San Diego, CA

DTx Pharma; Inc. is a San Diego-based company.

Pharma
Series B$267.0M
Vividion Therapeutics
San Diego, CA · Founded 2017 · 126 employees

Vividion Therapeutics is a proprietary Screening founded in 2017.

Series BEngineering
Series C$80.0M
Pipeline Therapeutics
San Diego, CA · Founded 2017 · 31 employees

Pipeline Therapeutics is a small Molecule for MS founded in 2017.

Series CBiopharmaceutical
Series D$255.0M
Ambrx
San Diego, CA · Founded 2003 · 126 employees

A biopharmaceutical company developing protein therapeutics

Series DBiomedical engineering
Series A$46.5M
Output
Los Angeles, CA · Founded 2013 · 6 employees

Output is a United Kingdom-based company.

Series AAI-powered Drug Discovery
Series E$171.5M
Novus Therapeutics
Irvine, CA · Founded 2017 · 31 employees

Novus Therapeutics is an Irvine; California-based company founded in 2017.

Series ETechnology
Series A$29.0M
Libra Therapeutics
San Diego, CA · Founded 2019 · 6 employees

Libra Therapeutics is a small Molecules for Neurodegenerative Indications founded in 2019.

Series AEngineering
Series C$120.0M
Amplyx Pharmaceuticals
San Diego, CA · 31 employees

Amplyx Pharmaceuticals; Inc. is a preclinical stage company focusing on the development of small molecule drugs.

Series CBiology
$52.0M
GPB Scientific
San Diego, CA

GPB Scientific is an automation of Cell Therapy Manufacturing.

Engineering
Series C$22.0M
Cold Genesys
Irvine, CA · Founded 2010 · 31 employees

Cold Genesys is a privately-held; immunotherapy based biopharmaceutical company

Series CBiology
Series A$120.0M
Mirum Therapeutics
San Diego, CA

Mirum Therapeutics is a San Diego-based company in the pharmaceutical industry.

Series APharmaceutical industry
Series A$33.0M
Qpex Biopharma
San Diego, CA · Founded 2018 · 31 employees

Qpex Biopharma is a San Diego-based company founded in 2018.

Series ABiopharmaceutical
Series A$60.0M
Neurana Pharmaceuticals
San Diego, CA

Neurana Pharmaceuticals is a small Molecule.

Series ABiomedical engineering
Series C$79.0M
Synthorx
La Jolla, CA · Founded 1954 · 10001 employees

Synthetic biology company that created novel DNA base pairs and uses them to incorporate novel amino acids into proteins for potential therapeutics in areas of cancer and autoimmune disorders.

Series CCancer
Series C$34.5M
Avelas Biosciences
San Diego, CA · Founded 2009 · 31 employees

A company focused on developing products for oncology surgery and therapeutic intervention

Series CMedical diagnostics
Series A$13.6M
Bioniz
Irvine, CA

Bioniz is a multi-cytokine inhibitory therapeutics.

Series AEngineering
$32.0M
Biotheranostics
San Diego, CA · Founded 2008 · 126 employees

A biotechnology company developing molecular-based diagnostic; prognostic; and predictive medical tests designed to help healthcare practitioners treat cancer.

Therapeutics
$138.6M
Cerulean Pharma, Inc
San Diego, CA · Founded 2006 · 31 employees

Cerulean Pharma; Inc is a company founded in 2006 by Ram Sasisekharan.

Therapeutics
Series D$62.1M
Crown Bioscience
San Diego, CA · Founded 2006 · 3001 employees

Crown Bioscience is a contract research organisation for drug discovery; best known for oncology models and also working in cardiovascular and metabolic disease; with sites across the United States; E

Series DConsumer biotechnology
Series C$76.8M
Aratana Therapeutics
San Diego, CA · Founded 2010 · 126 employees

A company developing therapeutics for veterinary medicine

Series CBiotechnology
Series E$65.0M
Auspex Pharmaceuticals
San Diego, CA · Founded 2001 · 351 employees

A biopharmaceutical company that develops therapeutics to treat depressive disorders

Series EBiotechnology
Series A$3.6M
Meditope Biosciences, Inc.
Pasadena, CA · Founded 2011 · 6 employees

A biotechnology company developing cancer therapeutics based on antibodies

Series ABiology
$122.0M
Aragon Pharmaceuticals
San Diego, CA · Founded 2009

A company that develops therapeutics for the treatment of cancer

Healthcare
$4.3M
GeneTex
Irvine, CA · Founded 1997 · 126 employees

GeneTex is a research Antibodies founded in 1997.

Biology
$6.7M
CombiMatrix
Irvine, CA · Founded 2005 · 126 employees

CombiMatrix is an Irvine; California-based healthcare company developing products and service for drug development; genetic analysis and diagnostics.

Biotechnology
Series A$23.0M
Femta Pharmaceuticals
San Diego, CA · 31 employees

Femta Pharmaceuticals is a biotechnology company that develops protein therapeutics

Series ABiotechnology
Series E$20.0M
Nereus Pharmaceuticals
San Diego, CA · Founded 1988 · 31 employees

A company developing biologically active compounds and drug candidates

Series EPharmaceutical industry
$260.0M
Prometheus Laboratories
San Diego, CA · Founded 1999 · 126 employees

A company developing pharmaceutical and diagnostic products to help physicians personalize patient care

Biology
$15.6M
Actimis Pharmaceuticals
San Diego, CA · 126 employees

A biopharmaceutical company developing small molecule therapeutics for respiratory and inflammatory disorders

Biotechnology
Series D$28.0M
Genoptix
San Diego, CA · Founded 1999 · 351 employees

Genoptix is a Carlsbad; California-based medical diagnostics company offering next-generation sequencing for oncology founded in 1999 by Tina Nova.

Series DGenomics
Avenzo Therapeutics, Inc. hero photo
$656.4M
Avenzo Therapeutics, Inc.
San Diego, CA · Founded 2022

Developing the next generation of oncology therapies for patients.

Healthcare
$413.0M
Mirador Therapeutics, Inc.
San Diego, CA · Founded 2023

Mirador Therapeutics is focused on discovering and developing precision medicines for immune-mediated inflammatory and fibrotic diseases using its Mirador360™ engine, which harnesses biology, multi-modal data, AI, and advanced analytics.

Healthcare
$400.2M
Avidity Biosciences, Inc.
San Diego, CA

Avidity Biosciences is a company driven by the mission to profoundly improve people's lives by revolutionizing a new class of targeted RNA therapeutics through its Antibody Oligonucleotide Conjugates (AOC™) platform.

Healthcare