Pharmaceutical & Biopharma startups in Southern California

Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.

Anchored by our protein-engineering expertise and our proprietary single-domain antibody platform, we’ve developed a unique pipeline of therapeutic candidates.

ADARx Pharmaceuticals, Inc. is a company that develops RNA medicines leveraging RNA science and proprietary targeted delivery platforms to silence the underlying cause of disease.

TORL Biotherapeutics LLC is a biopharmaceutical company focused on the discovery, development, and commercialization of novel antibody-based therapies to improve and extend the lives of cancer patients.

Pelage Pharmaceuticals, Inc. is developing regenerative medicines for hair loss, specifically PP405, a non-invasive, topically-applied small molecule solution that reactivates dormant hair follicles by targeting stem cells.

Renovaro revolutionizes cancer and neurology care through early detection, drug discovery, and personalized treatments. AI-powered precision medicine.

Enlaza Therapeutics is pioneering the field of covalent biologics, developing a novel classes of protein therapeutics based on its proprietary War-Lock™ platform.

Bright Peak Therapeutics is a company that uses its protein engineering capabilities to create multifunctional precision immunotherapies for the treatment of cancer.

CeleCor Therapeutics develops zalunfiban, an investigational next-generation GPIIb/IIIa platelet inhibitor designed for pre-hospital treatment of STEMI heart attacks.

VST BIO Corp is a biotechnology company developing first-in-class antibody drugs for the treatment of inflammatory and cardiovascular diseases, including stroke and acute myocardial infarction, as well as sepsis.

Protego Bio is a clinical-stage biotech developing first-in-class small molecule pharmacological chaperones for AL amyloidosis and other protein misfolding diseases.

SmartHealth Holdings, Inc. drives transformative innovation in healthcare diagnostics, including groundbreaking imaging systems for pathology, advanced vascular diagnostics, and oncology-focused solutions, notably with its pioneering MUSE technology for slide-free digital pathology.

GATC Health is a tech-bio company that uses proprietary AI to accelerate and de-risk the discovery and development of safer and more effective drugs for biopharma companies and investors.

NIS, a US based CRO, provides cryo-EM services to accelerate drug discovery, with structural biology, nanoparticle characterization, and GMP compliant imaging.

Rejuvenate Bio uses a gene therapy approach to treat chronic, age-related diseases by targeting the root causes of aging to create treatments for chronic conditions affecting both companion animals and humans.

Spinogenix is pioneering first-in-class, investigational therapeutics that restore brain synapses to improve the lives of patients worldwide.

Athos Therapeutics Inc. is a clinical stage biotechnology company that pioneers the development of artificial intelligence-based Precision Therapeutics for patients with Inflammatory Bowel Disease and other inflammatory diseases.

Tempo Therapeutics is a biotechnology and tissue engineering company based out of San Diego, CA specializing in speeding up patient recovery.

Model Medicines engineers first-in-class small molecules against biological choke points, using AI to advance pipeline-in-a-pill therapeutics across high-impact diseases.

Primrose Bio specializes in innovative manufacturing solutions for biotherapeutics and vaccines, setting new standards for quality and production efficiency.

Valora Therapeutics is developing AbLec™ multispecific antibodies and T-Lec™ T cell engagers — antibody-engineering platforms that decoy the glyco-immune checkpoint to create best-in-class therapeutics for cancer and autoimmune disease.

Syrna Therapeutics is pioneering a new class of mRNA targeting therapeutics that stop expression of disease-causing proteins

AeroRx Therapeutics is developing potential best-in-class nebulized combination therapies to improve COPD treatment.

SmallMolecules.com provides the largest listing of commercially-available small molecule products, assisting researchers to find the products they need to drive discovery.

SLAM BioTherapeutics, Inc. is a biotech company developing first-in-class human antibody-drug conjugates (ADCs) and bispecific monoclonal antibodies targeting blood cancers.

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.

Dimer Instruments creates instruments that enable real-time molecular analysis at multiple points during the pharmaceutical development process.

Developing novel long-acting therapeutics targeting chronic cardiometabolic diseases.

selectION Therapeutics' si-544 is a first-in-class Kv1.3 blocker and the first disease modifying treatment for T cell autoimmunity. Autoimmunity affects millions worldwide, but current treatments leave the root cause untouched. si-544 is the first therapy to safely and selectively deactivate disease-causing T cells, while preserving immune competence.

Excellos Labs is a cell therapy CDMO offering apheresis collection, PBMC and leukopak processing, T/NK cell isolation, and cGMP manufacturing for biotech and pharma.

Transposon Therapeutics, Inc. is developing TPN-101 (also known as Censavudine) and other LINE-1 reverse transcriptase inhibitors for the treatment of rare neurodegenerative diseases such as progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD).

XiltriX provides 24/7 live agent monitoring for biotech and biopharma labs and facilities that need to prevent sample loss and maintain compliance.

Certis Oncology Intelligence: predictive AI + advanced cancer models for more insightful data. Translational science, done differently.

Make medication work as intended. Custom Health connects pharmacy, in-home technology, and pharmacist-led care for 98% adherence and improved outcomes.

VivaMed BioPharma is a clinical-stage biopharma advancing new chemical entities and repurposed drugs across neurology, pain, psychiatry, pulmonology, and rheumatology. Operator-led development, global partnerships.

Dracen Pharmaceuticals is a private pharmaceutical company leveraging immuno-metabolism to create new cancer treatments, with their lead candidate, sirpiglenastat (DRP-104), being a unique glutamine inhibitor.

A28 Therapeutics is a clinical stage biopharmaceutical company developing a novel platform technology to treat multiple cancer types

Synedgen develops first-in-class therapeutics that improve patient outcomes by promoting barrier function to repair mucosal injury, with their lead asset MIIST305 aimed at repairing GI mucosal injury.

Discover Allevion Therapeutics’ Allevx™ Smart-Band, a wearable device designed to reduce movement-related disorders due to Essential Tremor.

Navega Therapeutics is harnessing the precision of zinc-finger and CRISPR based epigenome regulation to enable next-generation gene therapies for chronic pain and precision pain management.

Paralos Bioscience Inc. is developing phage-drug conjugates using a modular M13 phage drug delivery platform designed to concentrate payloads at specific targets.

Yatiri Bio, Inc. is re-enisioning the pharmaceutical industry's current drug discovery process by integrating patient data sets with testable empirical models to guide patient selection and clinical development, utilizing advanced proteomics and bioinformatics tools and deep learning models.

BRT Biotechnologies provides high-quality macrocycle libraries using its proprietary BRiTeCycle® platform to advance drug discovery and enable rapid identification of promising drug leads for treating hard-to-drug targets.

Nano porous silicon particles for controlled release drug delivery for the treatment of ocular diseases such AMD and for application to oncology

Developing Life-Changing Therapeutics For Our Pets Monoclonal antibodies (mAbs) for modern veterinary practices Developing Life-Changing Therapeutics For Our Pets Monoclonal... Read More

Caradon Therapeutics, Inc. develops novel disease-modifying peptide-based therapeutics for cardiometabolic diseases in humans and companion animals using proprietary enabling technology to create long-acting formulations.

Celia Group, Inc., through Celia Health and CeliaRx, provides longevity-first telehealth services with personalized, proactive care, offering programs and pharmaceutical-grade peptides designed for health optimization.

Discover Trethera’s breakthrough therapy TRE-515 for autoimmune, oncology, and neuroinflammatory diseases. Learn about our science-driven innovation.

Okogen, Inc. is a clinical stage ophthalmic pharmaceutical company focused on developing a comprehensive treatment for both bacterial and viral acute infectious conjunctivitis.

Renova Therapeutics is focused on developing definitive treatments to restore health to people suffering from congestive heart failure and type 2 diabetes through transformational gene therapies.

Transforming Biomanufacturing Through Nanofiber Technology Cellevat3d® VAX microcarriers redefine viral vaccine production with >10-fold higher yields

Phythera Therapeutics, Inc. is a biotechnology company leveraging the power of natural compounds to modulate key biological pathways in cancer and tissue regeneration to improve human health.

Novoron Bioscience is pioneering lipoprotein-receptor drug development to repair damage and degeneration of the brain, spinal cord, and beyond, with therapies to block the spread of prion-like proteins and enhance spinal cord regeneration.

Kenai Therapeutics is a clinical-stage biotechnology company advancing off-the-shelf dopamine neuron replacement cell therapies and gene-modified medicines to cure neurological conditions.

Ambros Therapeutics is a clinical-stage biotechnology company focused on developing innovative and transformative medicines for diseases with a high unmet medical need, with its lead investigational program targeting complex regional pain syndrome type 1 (CRPS-1).

Sidewinder Therapeutics pioneers the next generation of bispecific antibody-drug conjugates (ADCs) to expand the therapeutic window for patients with difficult-to-treat cancers.

Replicate Bioscience leverages self-replicating RNA (srRNA) vectors to advance treatments across therapeutic areas like infectious disease, oncology, and autoimmune disorders.

Recludix Pharma is developing new oral precision medicines with selective inhibitors to tackle protein targets for people living with inflammatory diseases.

Angitia Biopharmaceuticals is a clinical-stage biotechnology company focused on the discovery and development of innovative therapeutics for serious musculoskeletal diseases.

Float is the full-stack platform for Specialty Pharma