Healthcare startups in Southern California

Platform matching families with pediatric occupational therapy, physical therapy, and speech specialists, with AI billing automation. Serves LA, Orange County, and San Diego.

Nutrition and longevity company behind the Fasting Mimicking Diet (Prolon), founded by USC's Dr. Valter Longo.

Biotech making affordable corrective eye-care products for physicians.

Develops FDA-authorized virtual reality therapeutics, including RelieVRx (formerly EaseVRx), a prescription VR program for chronic lower back pain.

Daré Bioscience (Nasdaq: DARE) is a San Diego-based biopharmaceutical company developing and commercializing therapies for women's reproductive and sexual health, an area of medicine it argues has been chronically underfunded relative to its size.

Specialized pelvic floor and women's health physical therapy.

AI and human transformation partner for healthcare operations, serving providers and payers.

Aggregates medical records from doctors, clinics, hospitals, labs, and pharmacies into one shared patient workspace.

Cosight builds always-connected telehealth devices — cellular- and satellite-ready — for video consultations and remote patient monitoring, with real-time translation and integration with FDA-approved medical devices, aimed at hospitals and healthcare providers.

Precise Behavioral is a company founded in 2022 by Nitin Nanda.

GetLabs is a healthcare company.

Embodied; Inc. is a robotics and AI company creating companion robots for human-centric care and wellness.

Frame is a Santa Monica; California-based company founded by Kendall Bird.

A health care company in California that focuses on improving quality of care.

Well Health Inc. is a Santa Barbara; California-based healthcare company founded in 2015.

CLARIFY MEDICAL; INC. is a San Diego-based healthcare company.

Modulated Imaging; Inc. is an Irvine; California-based company founded in 2005.

PatientSafe Solutions is a San Diego-based company founded in 2002.

Axonics Modulation Technologies is a sacral Neuromodulation Device founded in 2013.

Suneva Medical is an aesthetic Medicine founded in 2009.

Levyx provies an enterprise-class data management platform for a variety of big data applications.

Alphaeon is an Irvine; California-based healthcare company founded in 2013.

TigerText is a Santa Monica; California-based company.

A company that develops therapeutics for the treatment of cancer

PrescribeWellness is an Irvine; California-based company founded in 2010 by Al Babbington.

MD Insider is a Santa Monica; California-based company founded by Eric Wilson; David Norris and Jay Calvert.

Developing the next generation of oncology therapies for patients.

Mirador Therapeutics is focused on discovering and developing precision medicines for immune-mediated inflammatory and fibrotic diseases using its Mirador360™ engine, which harnesses biology, multi-modal data, AI, and advanced analytics.

Avidity Biosciences is a company driven by the mission to profoundly improve people's lives by revolutionizing a new class of targeted RNA therapeutics through its Antibody Oligonucleotide Conjugates (AOC™) platform.

Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.

Nalu Medical offers a neurostimulation system that provides a long-term solution for managing intractable chronic nerve pain.

Merck agreed to acquire the San Diego biotech for approximately $9.2 billion in November 2025.

Biolinq Inc. develops the Biolinq Shine™ sensor, which is a fully autonomous, needle-free glucose sensor that integrates glucose, activity, and sleep information.

Co-founded by Drew Weissman, the 2023 Nobel Prize winner in Physiology or Medicine for mRNA vaccine research, alongside CAR-T pioneer Carl June; the company was later acquired by AbbVie.

Rakuten Medical is developing the Alluminox® platform, an investigational platform based on photoimmunotherapy, to transform cancer treatments.

Founded by Ken Song and launched with over $370 million (later exceeding $500 million) from investors including Venrock Healthcare Capital Partners, RA Capital Management, and Fairmount.

Anchored by our protein-engineering expertise and our proprietary single-domain antibody platform, we’ve developed a unique pipeline of therapeutic candidates.

ADARx Pharmaceuticals, Inc. is a company that develops RNA medicines leveraging RNA science and proprietary targeted delivery platforms to silence the underlying cause of disease.

ABA therapy and comprehensive autism care for children, from diagnosis through developmental and medical therapy. Physician-led and in-network. Find a center near you.

TORL Biotherapeutics LLC is a biopharmaceutical company focused on the discovery, development, and commercialization of novel antibody-based therapies to improve and extend the lives of cancer patients.

Equip Health provides virtual eating disorder treatment through a 5-person care team that includes a therapist, medical provider, dietitian, family mentor, and peer mentor.

Lightship is a clinical trial site network that expands participant choice through in-clinic, hybrid, virtual, and mobile research models.

Pelage Pharmaceuticals, Inc. is developing regenerative medicines for hair loss, specifically PP405, a non-invasive, topically-applied small molecule solution that reactivates dormant hair follicles by targeting stem cells.

Endeavor BioMedicines is a clinical-stage biotechnology company developing transformational medicines for life-threatening diseases.

Renovaro revolutionizes cancer and neurology care through early detection, drug discovery, and personalized treatments. AI-powered precision medicine.

A Foresite Labs-incubated biotech backed by Foresite Capital, Qiming Venture Partners, and Samsara BioCapital that raised over $100M before being folded into Candid Therapeutics' $370M launch in 2024.

Autobahn aims to improve life health for people affected by CNS disorders by driving the regenerative power of the human body.

JenaValve Technology Inc. offers the Trilogy Transcatheter Heart Valve, which is an FDA-approved TAVR system specifically designed for aortic regurgitation, utilizing locator technology for alignment and secure anchoring.

Enlaza Therapeutics is pioneering the field of covalent biologics, developing a novel classes of protein therapeutics based on its proprietary War-Lock™ platform.

TRC 2004 was co-founded by Third Rock Ventures and Two River, the same investor group behind Kite Pharma (sold to Gilead for roughly $11.9B), and later emerged publicly as Candid Therapeutics with a $370M capital raise.

Proactive health memberships combining Whole Body MRI, advanced blood biomarker testing, and ongoing clinical guidance—designed to help you track your health year over year.

Rebuilding healthcare with AI at the core

Part of the NantWorks ecosystem of biotech and health companies founded by billionaire physician-entrepreneur Patrick Soon-Shiong, who also owns the Los Angeles Times and invented the cancer drug Abraxane.

Gene therapy company that emerged from stealth in June 2023 with a $51M Series A co-led by Westlake Village BioPartners, developing AAV-based genetic medicines for muscle and heart disease.

CeleCor Therapeutics develops zalunfiban, an investigational next-generation GPIIb/IIIa platelet inhibitor designed for pre-hospital treatment of STEMI heart attacks.

VST BIO Corp is a biotechnology company developing first-in-class antibody drugs for the treatment of inflammatory and cardiovascular diseases, including stroke and acute myocardial infarction, as well as sepsis.

Plexium is a next-generation targeted protein degradation (TPD) company that discovers Monovalent Direct Degraders and Molecular Glues.