Healthcare startups in Southern California

Co-founded in 2018 by Scott Glenn and Lauren Otsuki, the skincare-tech company (parent of the Ourself brand) is backed by Lightspeed Venture Partners and added former Allergan CEO Brent Saunders to its board.

Discover how Immunis, a private biotechnology company is developing new secretome products for the treatment of age-related immune dysfunction

Oncocyte is a publicly traded diagnostics company (Nasdaq: OCX) that later renamed itself Insight Molecular Diagnostics and relocated its headquarters to Nashville.

SRT Therapeutics was founded in 2024 by former leaders of Prometheus Biosciences, including President & CEO Lauren Otsuki, and launched with roughly $47M in funding.

Restora Medical, Inc. focuses on Restorative Sleep Apnea Therapy using Targeted Nerve Stimulation.

Ceresti reduces hospitalizations and medical costs for people living with dementia by activating family caregivers to detect changes in the patient's condition.

Co-founded by Anton Kittelberger and Frank Westermann, who himself lives with diabetes; backers include Define Ventures and 7Wire Ventures.

Protego Bio is a clinical-stage biotech developing first-in-class small molecule pharmacological chaperones for AL amyloidosis and other protein misfolding diseases.

The most comprehensive executive health assessment — full-body MRI, whole genome sequencing, 120+ biomarkers & AI analysis in one visit. Starting at $8,000.

Discover vMap - The FDA-Cleared Non-Invasive AI-based Arrhythmia Analysis Solution by Vektor Medical. Improve Cardiac Ablation Efficiencies & Outcomes Today.

Elevating senior healthcare together. Discover comprehensive primary care, preventive care, behavioral health and more. Partner with us for a healthier future.

California-based IV therapy manufacturer serving hospitals, IDNs, and medical device OEMs across North America. ISO13485 certified with 50+years of expertise.

The U.S. operating arm of CODAN Companies, a Danish medical device manufacturer founded in 1939, with its American headquarters in Santa Ana, CA.

SmartHealth Holdings, Inc. drives transformative innovation in healthcare diagnostics, including groundbreaking imaging systems for pathology, advanced vascular diagnostics, and oncology-focused solutions, notably with its pioneering MUSE technology for slide-free digital pathology.

Alume Biosciences is developing nerve illumination technology, specifically bevonescein (ALM-488), to help surgeons protect and preserve nerve function during surgery by making nerves glow.

858 Therapeutics (its name references San Diego's 858 area code) has raised $110M across Series A and B rounds led by Versant Ventures and Avidity Partners, with participation from NEA and Insight Partners.

Poseida Therapeutics, a San Diego cell and gene therapy company founded by Eric Ostertag and once listed on Nasdaq as PSTX, was acquired by Roche in a December 2024 tender offer at $9.00/share cash plus a contingent value right.

AI-powered risk adjustment software designed to increase the profitability of Medicare risk contracts.

Serimmune was founded by Patrick Daugherty, a former UC Santa Barbara chemical engineering professor who also co-founded CytomX Therapeutics; backers include Illumina Ventures, LabCorp, and Merck.

The key to managing cancer is early detection. ClearNote Health makes this possible by finding signals of cancer in the blood early

German skincare giant Beiersdorf (maker of Nivea) became an investor in the company; Amicrobe later rebranded as Macro Biologics.

Lumati is a global holistic wellness optimization platform redefining longevity through science, technology, and personalized care — supporting cellular health, promoting recovery, and sustaining vitality.

Pictor Labs is The Virtual Staining Company enabling digital pathology adoption through computational virtual staining technology that preserves tissue for comprehensive downstream analysis.

SYLKE® Skin Closure is a sterile, single-use, silk fibroin mesh strip with a pressure-sensitive adhesive intended for topical skin closure and wound support. The device is used to hold together well-approximated skin edges of a wound, and to cover and protect the wound. Learn more at sylke.com.

ThinkBio.Ai is an AI-powered healthcare and life sciences solutions company, transforming complex data into actionable insights for better, faster decision-making.

Rejuvenate Bio uses a gene therapy approach to treat chronic, age-related diseases by targeting the root causes of aging to create treatments for chronic conditions affecting both companion animals and humans.

Rapalogix is advancing a portfolio of TORC1-selective therapies and pro-longevity skincare products, addressing skin aging and disease at the root to extend skin healthspan.

Spinogenix is pioneering first-in-class, investigational therapeutics that restore brain synapses to improve the lives of patients worldwide.

Paulex Bio stands at the threshold of what could be a transformative breakthrough for type 1 and type 2 diabetes: beta cell regeneration through an oral medicine designed to eliminate the root cause of diabetes.​

Athos Therapeutics Inc. is a clinical stage biotechnology company that pioneers the development of artificial intelligence-based Precision Therapeutics for patients with Inflammatory Bowel Disease and other inflammatory diseases.

AristaMD empowers primary care providers with excellent specialty care - improving patient outcomes with timely, cost-effective access.

Tempo Therapeutics is a biotechnology and tissue engineering company based out of San Diego, CA specializing in speeding up patient recovery.

Astiva Health, a Costa Mesa Medicare Advantage HMO, was co-founded by physician Dr. Tri Nguyen (CEO) and Chi Luong, and reported 188% membership growth to over 30,000 members.

Model Medicines engineers first-in-class small molecules against biological choke points, using AI to advance pipeline-in-a-pill therapeutics across high-impact diseases.

Price transparency and plan design tools for self-funded health plan comparisons and enhanced employee benefits strategies.

Syndex Bio introduces mcPCR, a novel and proprietary platform technology that preserves DNA methylation during DNA amplification, enabling simpler, faster, and more sensitive analysis of methylated DNA.

The Data Intelligence Network for Healthcare OutcomeMD’s Patient Experience Data Network™ turns de-identified patient-reported outcome measures (PROMs) into act

Primrose Bio specializes in innovative manufacturing solutions for biotherapeutics and vaccines, setting new standards for quality and production efficiency.

We explore the immense therapeutic opportunities to help those bound by autoimmune neuropsychiatric diseases.

In only five minutes and a penny-sized patch, Mindera Health technology captures thousands of RNA transcripts. We enable scalable collection and analysis of individualized genetic information to provide actionable, data-driven decisions for patients, providers and payers.

Valora Therapeutics is developing AbLec™ multispecific antibodies and T-Lec™ T cell engagers — antibody-engineering platforms that decoy the glyco-immune checkpoint to create best-in-class therapeutics for cancer and autoimmune disease.

Founded by physician-entrepreneur Remo Moomiaie-Qajar, M.D.; the San Diego biotech has raised $14.4M in funding, including from Partners Investment.

Syrna Therapeutics is pioneering a new class of mRNA targeting therapeutics that stop expression of disease-causing proteins

RCE Technologies is developing Infrasensor™, a non-invasive wearable that uses infrared spectroscopy and machine learning to detect severe coronary artery occlusion in about three minutes, without a blood draw — aimed at catching the 60%+ of heart attacks that standard chest-pain triage misses.

Founded by entrepreneurs Simon Arkell and Alex Dickinson with seed funding from AIX Ventures and Page One Ventures; the company later rebranded as Ryght.

Cooler Heads is the creator of Amma™, an FDA-cleared scalp cooling system that helps cancer patients reduce hair loss during chemotherapy. Amma delivers hospital-grade cold-cap therapy that’s simple, portable, and patient-first.

Digital Surgery Systems, Inc. is the legal name behind True Digital Surgery, a Goleta, CA maker of 3D robotic-assisted surgical microscopy systems that was fully acquired by German medical device company B. Braun SE in September 2025.

AeroRx Therapeutics is developing potential best-in-class nebulized combination therapies to improve COPD treatment.

We bring cell therapies to patients through innovative point-of-care manufacturing solutions.

Avicena, LLC develops microLED-based optical interconnects for high-speed communications, enabling energy-efficient AI data centers and GPU clusters to scale up.

Learn how Genomic Life enhances health and well-being through genetic screenings, early detection, personalized cancer navigation, and ongoing support. Optimize employee benefits and create a healthier workforce.

EGB Ventures is a physician-led venture formation family office focused on creating, financing, and developing biotechnology companies built around clinically validated therapeutic opportunities.

DermOQ was founded by Bradley Patt, who previously served as CEO of medical imaging company Gamma Medica.