Healthcare startups in Southern California

SLAM BioTherapeutics, Inc. is a biotech company developing first-in-class human antibody-drug conjugates (ADCs) and bispecific monoclonal antibodies targeting blood cancers.

Bringing Confidence to your Prostate Cancer Treatment Decisions A revolutionary platform that delivers tailored insights for prostate cancer management,

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.

EpiPlex™ assay detects RNA modifications by proximity barcoding and short read RNA sequencing, revealing insights into gene regulation for disease research.

We are a pioneering biotechnology company dedicated to producing innovative solutions to treat traumatic nerve injury.

The Tally Surgical retained sponge prevention solution utilizes UHF RFID to simplify and speed an accurate count of surgical sponges and towels.

Tele911 integrates emergency medicine telehealth and patient navigation into 911 & EMS systems.

Cellibre, Inc. uses biology as a manufacturing technology, leveraging nature to create sustainable products through strain engineering, biochemistry, and precision fermentation.

Qureator provides integrated human disease model and AI platform to evaluate treatment efficacy in complex disease models.

Independa Health Hub® is a simple to use ecosystem of health & wellness benefits on any screen — TV, tablet, computer, or phone. Many benefits absolutely FREE!

Developing novel long-acting therapeutics targeting chronic cardiometabolic diseases.

Gain unprecedented kinetic insights into your CRISPR workflow with the CRISPR QC’s analytics platform

EyeArt by Eyenuk is an autonomous, FDA-cleared AI for diabetic retinopathy screening and disease detection at the point of care.

selectION Therapeutics' si-544 is a first-in-class Kv1.3 blocker and the first disease modifying treatment for T cell autoimmunity. Autoimmunity affects millions worldwide, but current treatments leave the root cause untouched. si-544 is the first therapy to safely and selectively deactivate disease-causing T cells, while preserving immune competence.

Ospitek empowers surgical centers with real-time IoT and AI-enhanced solutions, improving workflow efficiency, patient care, and staff coordination. Seamlessly integrate with legacy systems and unlock unparalleled operational visibility with Ospitek’s cutting-edge platform.

Preventive health platform for dogs. AI Health Companion, at-home blood draws & 40+ biomarker panel. Vet-built care plans for early disease detection.

Founded and led by Dr. Sheila Gujrathi, a physician-scientist and serial biotech executive who also founded/chairs Vidya Therapeutics and Lila Biologics and sits on the board of Janux Therapeutics; the company is based in Encinitas, CA.

AcuraStem is a patient-based biotechnology company pioneering how treatments are developed for neurodegenerative diseases, including sporadic ALS and FTD, using its proprietary disease-modeling platform, iNeuroRx®.

Excellos Labs is a cell therapy CDMO offering apheresis collection, PBMC and leukopak processing, T/NK cell isolation, and cGMP manufacturing for biotech and pharma.

California Compounding is a trusted compounding partner for telehealth and clinics, offering office stock programs, prescriber portals, and scalable fulfillment.

Transposon Therapeutics, Inc. is developing TPN-101 (also known as Censavudine) and other LINE-1 reverse transcriptase inhibitors for the treatment of rare neurodegenerative diseases such as progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD).

XiltriX provides 24/7 live agent monitoring for biotech and biopharma labs and facilities that need to prevent sample loss and maintain compliance.

Resolute Science, Inc. is a biotechnology company developing a pipeline of first-in-class synthetic drug conjugates, specifically Macrophage-Targeted Conjugates (MAC-TACs), for the treatment of solid tumors.

Nasdaq-listed (QLGN); received a $41 million strategic PIPE investment from Faraday Future, whose founder is Chinese entrepreneur YT Jia (Jia Yueting).

Founded in 2016 by CEO Matt Lashey, who created the chemoWave cancer-treatment tracking app; investors include Plug and Play Tech Center.

Vesica Health, Inc. brings clarity to clinical decisions by combining next-generation molecular diagnostics and Blue Light Cystoscopy to improve early detection and diagnosis for bladder cancer patients, and offers the noninvasive urine-based AssureMDx test to identify hematuria patients at increased risk for bladder cancer.

ClearFlow develops medical technologies including PleuraFlow Active Clearance Technology to reduce Retained Blood Syndrome complications and ClearFix Rigid Sternal Fixation for stabilization and fixation of anterior chest wall fractures.

NeuraNova's mission is to revolutionize neurovascular diagnostics to respond rapidly to critical moments.

AI-driven medical coding from Synaptec Health - a more accurate, secure, and comprehensive solution for all your medical coding needs.

Tenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.

Founded in 2018 by Dr. Virender K. Sharma, a serial medtech entrepreneur and former Mayo Clinic professor, alongside CEO Dr. Holger Friedrich; the company develops single-shot catheter ablation technology for atrial fibrillation.

Acurion's OncoGaze™ technology delivers critical genomic insights at the biopsy stage, empowering oncologists to make precision therapy a reality for more patients.

Why Use the Virchow Medical Crow’s Nest Biopsy Catchment System? To Improve Core Needle Biopsy Collection, Tissue Management, and Access to Targeted Diagnostics.

Meduloc provides minimally invasive, intramedullary implants that offer stable fixation and secure reduction for all types of small, long-bone fractures.

ChromaCode is a leading provider of HDPCR™ multiplexing technology for genomic solutions. Our breakthrough platform enables labs, physicians, and patients to access actionable biomarkers faster and more affordably. With HDPCR™, you can get critical and complete data, analyzed with simplicity, without paying for excess information.

2A Biosciences is pioneering neural restoration by advancing precision agonists to restore neural circuitry and immune balance, having demonstrated in vivo nerve regeneration via 5-HT2A modulation.

Precision fit and fully alignable. Unbelievably durable, versatile and affordable. It’s time for the UniLeg.

Co-founded by Jeffrey Port and William Blair; the company was acquired by Merit Medical Systems, expanding Merit's therapeutic oncology portfolio.

Virgo builds frontier AI models to solve diseases mediated by the gut. Our flagship model, EndoDINO, was trained on the largest GI endoscopy dataset.

Certis Oncology Intelligence: predictive AI + advanced cancer models for more insightful data. Translational science, done differently.

The majority of molecules sequenced are uninformative. Jumpcode Genomics is changing that by helping researchers boost usable NGS data.

Does business as Mahmee, a maternal health startup co-founded by Melissa Hanna that raised $3M in seed funding from Mark Cuban and Serena Williams.

Laguna Tech USA is developing the ZETA Transcatheter Aortic Valve System, a balloon-expandable valve solution designed for Aortic Regurgitation and Aortic Stenosis.

Illudent (operating as Illudent Therapeutics), a San Diego cancer-treatment biotech, has raised roughly $3.25-5.2M in funding from investors including Ulu Ventures and SeedFolio.

VivaMed BioPharma is a clinical-stage biopharma advancing new chemical entities and repurposed drugs across neurology, pain, psychiatry, pulmonology, and rheumatology. Operator-led development, global partnerships.

Effortless, science-backed oral microbiome insights from saliva. Decode your saliva for personalized wellness.

Ocelot Bio closed a $36M Series A led by RA Capital Management, Venrock, and Vivo Capital.

Amydis is the leader in developing a new class of diagnostic compounds that enable digital detection and monitoring of human disease-related molecular biomarkers through standard ocular imaging cameras.

MedVector connects healthcare providers with clinical trials by protecting the patient/doctor relationship, compensating for additional workload, aiding in patient identification, and enhancing patient care through advanced medicine.

Biologic solutions to optimize enthesis reformation, EnFix® is the future of bone to tendon healing.

Discover OrthoRPM, transforming home exercise programs with guided rehabilitation, motion tracking, and connected digital therapy solutions for clinics without paper.

CARI Health empowers clinicians to personalize methadone dosing for every patient.