Healthcare startups in Southern California

SureCount SmartTrays streamline surgical instrument management, reducing errors, speeding counts, and improving safety across OR and SPD teams.

Sensible Care Inc. offers online therapy and psychiatry for individuals, couples, and families, including adults, teens, and children, with access to in-network care.

Formerly operated Gamma Knife stereotactic radiosurgery centers; the publicly traded company (OTC: USNU) renamed itself Elite Health Systems Inc. in September 2024.

Dracen Pharmaceuticals is a private pharmaceutical company leveraging immuno-metabolism to create new cancer treatments, with their lead candidate, sirpiglenastat (DRP-104), being a unique glutamine inhibitor.

Varsity Healthcare Partners builds leading healthcare companies, employing a differentiated partnership model.

Transforming medicine through cellular therapies that restore, regenerate, and repair tissues and organs

Synedgen develops first-in-class therapeutics that improve patient outcomes by promoting barrier function to repair mucosal injury, with their lead asset MIIST305 aimed at repairing GI mucosal injury.

AscentX Medical, Inc. is dedicated to improving quality of life through injectable regenerative therapy focusing on advanced soft tissue engineering using autologous tissue engineering technology with injectable microspheres.

CancerVax is a pre-clinical biotech company developing a novel Universal Cancer Treatment Platform that uses artificial intelligence to disguise cancer cells to look like measles, thereby tricking the body's immune system into killing them.

Discover Allevion Therapeutics’ Allevx™ Smart-Band, a wearable device designed to reduce movement-related disorders due to Essential Tremor.

Navega Therapeutics is harnessing the precision of zinc-finger and CRISPR based epigenome regulation to enable next-generation gene therapies for chronic pain and precision pain management.

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Paralos Bioscience Inc. is developing phage-drug conjugates using a modular M13 phage drug delivery platform designed to concentrate payloads at specific targets.

BRT Biotechnologies provides high-quality macrocycle libraries using its proprietary BRiTeCycle® platform to advance drug discovery and enable rapid identification of promising drug leads for treating hard-to-drug targets.

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Impulse Medical Technologies - A leading manufacturer and distributor of high-quality medical electrodes and diagnostic supplies. Parent company of The Electrode Store and TES Wholesale.

SeqOnce was co-founded in 2014 by Chris Angermayer and Joseph Dunham as a spinout from the University of Southern California, and has drawn investment from Wavemaker 360 Health and Mount Wilson Ventures.

BioSig Technologies (Nasdaq: BSGM), originally a medical-device company, pivoted into real-world-asset tokenization through a 2025 merger with Streamex Exchange, backed by mining financier Frank Giustra as a strategic advisor.

Controlled Delivery Systems is developing a medical device to treat venous insufficiency without thermal energy or a permanent implant.

Nano porous silicon particles for controlled release drug delivery for the treatment of ocular diseases such AMD and for application to oncology

Berman Medical is building the image-guided navigation layer for point-of-care procedures to make patient-specific 3D visualization and navigation accessible.

Azora Therapeutics, an LA biopharma founded in 2019 by Matt Davidson and Julie Saiki, was acquired by Adial Pharmaceuticals in 2026 for up to $64 million.

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Caradon Therapeutics, Inc. develops novel disease-modifying peptide-based therapeutics for cardiometabolic diseases in humans and companion animals using proprietary enabling technology to create long-acting formulations.

GABA Therapeutics partnered with atai Life Sciences (co-founded by Florian Brand) in a Series A deal worth up to $15.5 million to develop a novel anxiety treatment; it was co-founded by Richard Farrell.

Explore Persperion for innovative sweat sensing technology and metabolic health monitoring at your fingertips.

LungLife AI is a diagnostic company focused on the early detection of lung cancer from a simple blood draw enhanced by artificial intelligence.

Our mission is to provide a compassionate, world-class customer experience to the families we serve.

CeraRoot USA Inc. provides a ceramic implant system engineered for biological integration, offering various implant models, accessories, and services like custom prosthesis design and surgical guides.

Altolabs Inc. provides AI solutions for enterprises, designed for accountability, data residency, and full control over how intelligence is governed and deployed.

Unlocking the microbiome for better skin health The Human Body Relies On The Microbiome For: Inflammation Control Infection Protection Wound Healing And More The Microbiome Cannot Be Ignored For over 100 years, "skincare" has often treated

Discover Trethera’s breakthrough therapy TRE-515 for autoimmune, oncology, and neuroinflammatory diseases. Learn about our science-driven innovation.

My Village Innovations (MVI Medical) is a women-led medical device company co-founded by Andrea "Annie" Munoz, PA-C, and Alfonso Munoz, focused on reimagining the vaginal speculum for gynecologic care.

Aisona Care Inc. offers Sona, an AI-powered care companion for Seniors that shares health signals securely with their care team.

Operated as "The BXNG Club," a luxury boxing gym chain in San Diego; the company filed Chapter 11 bankruptcy in June 2024 and abruptly closed all its remaining locations.

Robin Capital backs ambitious founders at Angel to Series A. We invest in grit, software, and vision—supporting startups with capital, experience, and founder-first values.

Renova Therapeutics is focused on developing definitive treatments to restore health to people suffering from congestive heart failure and type 2 diabetes through transformational gene therapies.

Founded by MaryRose Reaston (co-founder/CSO) alongside CEO Brett Ottemeier; the Carlsbad-based company makes functional EMG diagnostic technology and has won an industry innovation award.

Carriero Foot and Ankle is a podiatric practice focused on treating foot and ankle conditions, led by Dr. Keenan Carriero and Dr. Zachary Kramer.

Unlocking New Indications for the in vivo CAR-T Modality

Seren Bio Corp. sells products categorized for weight loss, skin, hair and beauty, recovery, bacteriostatic water, and performance, energy & wellness.

Serafin Labs is a San Diego cancer-therapeutics company founded by CEO Sural Ranamukhaarachchi (UC San Diego bioengineering PhD) and affiliated with UCSD's Fraley Lab; it is still operating in stealth mode.

Intrigue Health aims to empower patients and healthcare providers with home diagnostics.