Healthcare startups in Southern California
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Avenzo Therapeutics, Mirador Therapeutics, and Avidity Biosciences are the three best-funded healthcare companies here, and all three are San Diego biotechs. That's not a coincidence — nearly every well-funded company in this category is based in San Diego's Biotech Beach, the research cluster built around UC San Diego, Scripps Research, and the Salk Institute.
Companies
$468Phythera Therapeutics, Inc. is a biotechnology company leveraging the power of natural compounds to modulate key biological pathways in cancer and tissue regeneration to improve human health.
$35Founded by Dr. Susanne B. Nicholas, a UCLA nephrology professor, to commercialize kidney-disease research from her own lab.
NeuroSigma is a bioelectronic medical device company that uses non-invasive trigeminal-nerve stimulation to treat chronic neurological disorders, including an FDA-cleared device for pediatric ADHD.
MedicalMex helps and protects international patients traveling to Mexico for affordable medical services, including weight loss surgery, plastic surgery, pain management, hair restoration, dental, vascular, more procedures, orthopedic surgery, and general surgery.
Novoron Bioscience is pioneering lipoprotein-receptor drug development to repair damage and degeneration of the brain, spinal cord, and beyond, with therapies to block the spread of prion-like proteins and enhance spinal cord regeneration.
Kenai Therapeutics is a clinical-stage biotechnology company advancing off-the-shelf dopamine neuron replacement cell therapies and gene-modified medicines to cure neurological conditions.
St. John’s Community Health is dedicated to providing compassionate, high-quality healthcare for all, offering medical, dental, pediatric, women's health, mental health, substance use, and homeless health services, as well as patient programs like case management and health education.
Midi Health is a virtual healthcare clinic for women that provides personalized care plans including treatments, products, and guidance designed around individual hormones and symptoms.
Ambros Therapeutics is a clinical-stage biotechnology company focused on developing innovative and transformative medicines for diseases with a high unmet medical need, with its lead investigational program targeting complex regional pain syndrome type 1 (CRPS-1).
Neomorph develops molecular glue degraders to target and destroy disease-causing proteins by engineering neomorphic protein surfaces.
Sidewinder Therapeutics pioneers the next generation of bispecific antibody-drug conjugates (ADCs) to expand the therapeutic window for patients with difficult-to-treat cancers.
RyboDyn is pioneering immunotherapy development by unlocking the dark proteome with its proprietary RyboCypher™ technology to reveal hidden targets and transform biological signals into breakthrough therapies.
Replicate Bioscience leverages self-replicating RNA (srRNA) vectors to advance treatments across therapeutic areas like infectious disease, oncology, and autoimmune disorders.
Recludix Pharma is developing new oral precision medicines with selective inhibitors to tackle protein targets for people living with inflammatory diseases.
OrangeTwist is a med spa that provides treatments ranging from facials to full-body transformations and also offers medical weight loss treatments.
Angitia Biopharmaceuticals is a clinical-stage biotechnology company focused on the discovery and development of innovative therapeutics for serious musculoskeletal diseases.
Macro Biologics designs, patents, and produces advanced biomaterials for healthcare, food and water applications, and packaging.
Primmune Therapeutics is a clinical-stage biotechnology company focused on developing systemic cancer immunotherapies that activate the immune system in a precise and controlled manner.
Sarmal is developing proprietary single molecule DNA sequencing technology and target detection technology for genomic detection.
Subsense is building the first NanoBCI, a non-surgical, nanoparticle-based Brain-Computer Interface platform designed to transform the treatment of neurological disorders by uniting the human brain, technology, and AI.
Sharpen DTX, by Resiliency Technologies, Inc., provides mental health literacy tools and prevention toolkits for schools, families, colleges, and community organizations to improve mental wellness and resiliency.
Keyframe Labs builds human foundation models that power lifelike, interactive avatars with photorealism, emotion, and real-time latency.
Roadrunner AI provides a workspace for the search, analysis, and synthesis of scientific literature, purpose-built for the rigor and methods of life sciences, healthcare, and biomedical research.
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