
Pasadena began in 1874 as the Indiana Colony, an agricultural settlement carved out of Rancho San Pasqual, and took its Ojibwa-derived name the following year before incorporating in 1886. Citrus groves and winter resort hotels drew wealthy industrialists west through the early 1900s, and in 1890 the city held its first Tournament of Roses parade. Throop Polytechnic Institute, founded in 1891, grew into the California Institute of Technology, and after World War II Caltech began managing the nearby Jet Propulsion Laboratory. That combination of scientific research and precision manufacturing turned Pasadena into a hub for aerospace and instrumentation work that continues today.
AI search/advertising company (ProRata.ai) backed by Touring Capital, Mayfield Fund, and Revolution Ventures; has raised more than $75M total, including a $40M Series B in September 2025.
Brasada Ranch is a family-friendly resort located just outside of Bend, Oregon that features luxurious accommodations, championship golf, world-class dining and amenities, and endless recreation throughout Central Oregon.

Virtualitics is an AI solutions company that transforms data into impactful action with AI readiness applications for defense, government, and enterprise.
Deep 6 AI, founded in 2013 by Brian Dolan and Wout Brusselaers with backing from Point72 Ventures and the Cedars-Sinai Accelerator, was acquired by Tempus AI (Nasdaq: TEM) in March 2025.

Fluid Efficiency’s removable DRA is designed to unlock capacity in natural gas liquids pipelines by reducing drag and then being removed before downstream processing.

Everest Properties is a privately-held real estate investment firm specializing in acquisition, recapitalization, and asset management of real estate.

Orbital AI Edge Compute for Next-Gen Space Operations
With a focus on long-term value creation, Park Ventures LLC strategically invests in select real estate holdings, development projects and private companies. From Land Investment in high-growth markets to commercial, residential and industrial Real Estate Development projects, we help communities
Avicena was founded in 2019 by Bardia Pezeshki and raised a $65M Series B led by Tiger Global with participation from SK Hynix and Prosperity7 Ventures.
Cre8tech Labs does business as Lender Price, a mortgage fintech that received a strategic investment from Regions Bank in 2018.

Tele911 integrates emergency medicine telehealth and patient navigation into 911 & EMS systems.

Mitico is a carbon-capture company built on technology developed at Caltech, founded in 2022 by Clément Cid, Alan Gu, and Leopold Dobelle; it raised a $4.3M seed round in 2025 led by Exergon.
Co-founded by CEO Sam Alworth and Dr. Qing Liu; this ALS/FTD biotech was awarded $7.5M in grant funding from California's stem cell agency (CIRM) toward its first human trial, on top of earlier NIH and DOD funding.
Co-founded by Shane Shahrestani, incubated through Caltech's OTTCP startup program; the company closed an oversubscribed $5M Series Seed Prime round in 2024 backed by investors including Freeflow Ventures and DigiTx Partners.
Lixte Biotechnology Holdings, Inc. (Nasdaq: LIXT) is a clinical-stage pharmaceutical company developing a new class of oncology treatments and cancer therapies called PP2A inhibitors.
Co-founded by Alex Watts, the LA-based startup has raised over $8M, backed by investors including Multicoin Capital.

Strengthen care and improve patient outcomes by prescribing a healthier lifestyle

Eydle operates accredited application security verification infrastructure aligned with enforcement frameworks across mobile, web, and cloud ecosystems.
Tap Systems was founded in Pasadena in 2015 by Dovid Schick and Dr. Sabrina Kemeny to build the Tap wearable finger-tap keyboard and mouse.
SeqOnce was co-founded in 2014 by Chris Angermayer and Joseph Dunham as a spinout from the University of Southern California, and has drawn investment from Wavemaker 360 Health and Mount Wilson Ventures.

Miso’s AI-powered kitchen automation platform to improve efficiency, reduce costs, and scale restaurant operations seamlessly.

Spinasana offers a balanced mix of premium rhythmic spin and hot yoga classes designed to strengthen, stretch and rejuvenate the body. Flexible membership options in Pasadena, CA.
GHN Career Academy was founded by career coach Ron Nash and is based in Pasadena, California.