Southern California's
Tech
Startup Directory
Showcasing Southern California's innovation, one startup at a time. Every funded and bootstrapped company, from seed round to first dollar of revenue, tracked as it happens.
Includes SEC Form D filings from the last 3 years, plus all-time totals for companies sourced from YC and news coverage.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Seed$71.0MEnigma is a physical AI startup building an intelligence layer for the robotics industry.
Seed$19.7MNIS, a US based CRO, provides cryo-EM services to accelerate drug discovery, with structural biology, nanoparticle characterization, and GMP compliant imaging.
Seed$19.2MUnlock Engagement, New Fans & Revenue Through Sports Betting
Seed$18.6MFounded by Dr. Stella Sarraf; its ALS drug candidate SPG302 received an FDA-authorized expanded access program in 2025.
Seed$17.2MUnlock quantum power with BlueQubit's quantum computing software! Seamlessly access and utilize quantum computers for groundbreaking advancements.
Seed$16.1MAstiva Health, a Costa Mesa Medicare Advantage HMO, was co-founded by physician Dr. Tri Nguyen (CEO) and Chi Luong, and reported 188% membership growth to over 30,000 members.
Seed$15.8MEggCo, Inc. is the legal entity behind the fertility startup Cofertility, founded by CEO Lauren Makler along with Halle Tecco and Arielle Spiegel.
Seed$14.8MWe explore the immense therapeutic opportunities to help those bound by autoimmune neuropsychiatric diseases.