Stanley Crooke founded Isis Pharmaceuticals in Carlsbad in 1989 to develop antisense therapy, a bet that took decades to pay off before Biogen partnership SPINRAZA won approval in 2016 and validated the whole platform; the company renamed itself Ionis Pharmaceuticals in 2015. That early antisense research base helped establish Carlsbad and the rest of San Diego's North County as a life-sciences cluster in its own right, distinct from but connected to San Diego's broader biotech scene to the south.
Co-founded by CEO Todd Harris and COO Daniel Bensen, and was incubated by venture firm Alta Partners before going public.
Equip was co-founded by CEO Kristina Saffran, who drew on her own recovery from anorexia; she previously co-founded the nonprofit Project Heal. Actress Kerry Washington has also personally invested in the company.

Carlsmed® uses patient data and digital technologies to create optimal surgical plans and personalized aprevo® spine fusion devices.
Co-founded in 2018 by Scott Glenn and Lauren Otsuki, the skincare-tech company (parent of the Ourself brand) is backed by Lightspeed Venture Partners and added former Allergan CEO Brent Saunders to its board.

Ceresti reduces hospitalizations and medical costs for people living with dementia by activating family caregivers to detect changes in the patient's condition.

Proper Voltage is the digital bridge that seamlessly links power and product, opening up access to more choices and possibilities.
The entity behind Nixon, the watch and accessories brand founded in 1997 by Andy Laats and Chad DiNenna, which is now backed by private equity firm Trilantic Capital Management.
German skincare giant Beiersdorf (maker of Nivea) became an investor in the company; Amicrobe later rebranded as Macro Biologics.

Unlock Engagement, New Fans & Revenue Through Sports Betting
Rapalogix is advancing a portfolio of TORC1-selective therapies and pro-longevity skincare products, addressing skin aging and disease at the root to extend skin healthspan.

Electrolytes formulated with premium, all-natural and organic ingredients. Instant Hydration replenishes you faster and longer than water alone.
This Carlsbad, CA private-equity vehicle for engineered stone manufacturing is run by managing member Oren Klaff, the investor and author best known for the bestselling sales book "Pitch Anything."
Founded by physician-entrepreneur Remo Moomiaie-Qajar, M.D.; the San Diego biotech has raised $14.4M in funding, including from Partners Investment.
Founded by Atandra Burman, the Carlsbad, California company is developing a transdermal wearable for early detection of heart attacks.

MUNICIPAL was founded in 2019 to inspire people to bet on themselves and make big things happen. The apparel & footwear we create combines best-in-class quality, versatile performance and extreme comfort.

Nasdaq-listed (QLGN); received a $41 million strategic PIPE investment from Faraday Future, whose founder is Chinese entrepreneur YT Jia (Jia Yueting).
ChromaCode is a leading provider of HDPCR™ multiplexing technology for genomic solutions. Our breakthrough platform enables labs, physicians, and patients to access actionable biomarkers faster and more affordably. With HDPCR™, you can get critical and complete data, analyzed with simplicity, without paying for excess information.
Co-founded by Jeffrey Port and William Blair; the company was acquired by Merit Medical Systems, expanding Merit's therapeutic oncology portfolio.

Virgo builds frontier AI models to solve diseases mediated by the gut. Our flagship model, EndoDINO, was trained on the largest GI endoscopy dataset.
AppTech Payments Corp provides multi-bank payment infrastructure designed for compliance, scale, and operational resilience. Explore the platform, partner program, company, news, FAQ, and contact pages to learn more.
Co-founded by Andrew Morris, Eric Brouwer, and Adolfo Velazquez, the company is developing a rapid lung-cancer diagnostic called the verifi LUNG test.

Effortless, science-backed oral microbiome insights from saliva. Decode your saliva for personalized wellness.
Through its health & fitness AI platform, PEAR creates personalized digital coaching experiences to help people move smarter, get healthier, and live happier.

Priwall helps you find and remove your personal data from data brokers. Protect your identity and reduce your digital footprint.
Ponto is a financial infrastructure company

SAFR Football Helmet Covers reduce the external blunt force that can cause traumatic brain injuries for all ages. Learn more!

Multi-carrier wireless internet for homes, businesses, and specialized equipment. No contracts, 24/7 support, and reliable connectivity across all 50 states.

Aptera is building hyper-efficient solar electric vehicles that get meaningful range from sunshine alone.
Founded by Ariel Trybuch, a fintech data/AI platform built for banks and credit unions.

The Vesteck Inc Endosuture Aneurysm Repair (ESAR) platform, Suture-Tight™, is revolutionizing the aneurysm repair space.
Struggling with your mental health? Our online counsellors meet with you through our video counselling platform, when and where it works best for you.
HAUSER is a world-class musician and magician of the cello. His passion is to show his audience the versatility of the cello. Watch latest videos and events!
Co-founder Dr. H. Kirk Hammond of UC San Diego previously co-founded Collateral Therapeutics; CEO and co-founder Jack W. Reich received an Entrepreneur of the Year award.

Bristlecone is the leading provider of connected logistics solutions, including AI applications, SAP integration, and more.
Founded by MaryRose Reaston (co-founder/CSO) alongside CEO Brett Ottemeier; the Carlsbad-based company makes functional EMG diagnostic technology and has won an industry innovation award.

Multi-model AI with a patent-pending AI Firewall — for teams where data privacy is not optional. 47 models, one workspace, sensitive data stays home.

Cut your writing time by 40% with AI-powered autocomplete

Float is the full-stack platform for Specialty Pharma