Medical Technology startups in Southern California

Platform matching families with pediatric occupational therapy, physical therapy, and speech specialists, with AI billing automation. Serves LA, Orange County, and San Diego.

Pharma and medical-device compliance software plus licensing consulting.

Nutrition and longevity company behind the Fasting Mimicking Diet (Prolon), founded by USC's Dr. Valter Longo.

Biotech making affordable corrective eye-care products for physicians.

Develops FDA-authorized virtual reality therapeutics, including RelieVRx (formerly EaseVRx), a prescription VR program for chronic lower back pain.

Cosight builds always-connected telehealth devices — cellular- and satellite-ready — for video consultations and remote patient monitoring, with real-time translation and integration with FDA-approved medical devices, aimed at hospitals and healthcare providers.

Daré Bioscience (Nasdaq: DARE) is a San Diego-based biopharmaceutical company developing and commercializing therapies for women's reproductive and sexual health, an area of medicine it argues has been chronically underfunded relative to its size.

Specialized pelvic floor and women's health physical therapy.

AI and human transformation partner for healthcare operations, serving providers and payers.

Aggregates medical records from doctors, clinics, hospitals, labs, and pharmacies into one shared patient workspace.

Renata Medical develops cardiovascular devices for children with congenital heart disease. Its Minima Stent System is the first balloon-expandable growth stent designed for neonates; infants and young

Khartis Therapeutics is a San Diego biotechnology company developing oral small-molecule medicines targeting clinically validated immunology pathways. Its lead program is an oral; selective IGF-1R inh

Amplifica is a San Diego clinical-stage biopharmaceutical company developing injectable treatments for hair loss. Rather than slowing loss; its approach works on the signalling molecules that govern t

Faye sells app-based whole-trip travel insurance; covering trip; health and belongings; with in-app claim filing and reimbursements paid to the traveller's phone wallet.

Precise Behavioral is a company founded in 2022 by Nitin Nanda.

Crystalys Therapeutics is a San Diego clinical-stage biotechnology company developing treatments for gout; a disease it argues remains badly served despite being common. Its lead candidate is in pivot

Rula is a Los Angeles-based mental healthcare company that connects patients with licensed therapists and psychiatric providers who accept their health insurance. Founded in 2019 as Path by Josh Bruno

Spiro Medical is developing an implantable neuromodulation system for patients with severe; uncontrolled asthma. Its approach applies targeted spinal nerve stimulation intended to modulate respiratory

Artera is a Santa Barbara agentic-healthcare company; founded in 2015; that provides AI-powered patient communications and care-navigation software for healthcare providers.

Founded in 2017; Onchilles Pharma is a drug-discovery and development company pioneering first-in-class cytotoxic therapies that selectively kill cancer cells while preserving and activating immune fu

Rarity PBC is a public benefit biotechnology company developing gene therapies for rare diseases; with an explicit focus on affordability and access.

Blueprint sells the longevity protocol Bryan Johnson developed on himself as a consumer product line - supplement stacks such as Longevity Mix and Essential Capsules; extra virgin olive oil; protein p

Honey Health automates healthcare back-office work with AI; handling medical record requests; clinical operations and administrative fulfilment for providers.

IO Health sells a workflow intelligence platform for home health and hospice providers.

SureCo is a Santa Ana health-benefits technology company founded in 2016 by Matthew Kim and Matt Christopherson. Its ICHRA platform helps employers fund individual health plans and supports enrollment

Bonsai Health is a Santa Monica; California-based healthcare technology company founded by Travis Schneider.

Sleep.ai; part of SleepScore Labs; provides B2B sleep intelligence solutions through APIs that power digital health; wellness; and consumer products. Originally founded in the Netherlands and later ac

DEBUT BIOTECHNOLOGY; INC. is a Carlsbad; California-based company founded in 2019.

Arnatar Therapeutics develops RNA medicines from a platform it calls DARGER; which pairs highly active siRNA for silencing a gene with ACT-UP1; an antisense technology that does the opposite and incre

Field Medical is a U.S.-based medical device company pioneering pulsed field ablation (PFA) technology for treating cardiac arrhythmias like ventricular tachycardia. Founded by Dr. Steven Mickelsen; i

Actio Biosciences is a biotechnology company pioneering precision medicine by developing genetically targeted therapies for both rare and common diseases. Leveraging advanced genomics; Actio aims to t

Parallel Bio is a Los Angeles; California-based biotechnology company developing curative immunotherapies and related technologies.

Inari is a biotechnology and agricultural technology company

Pleno is a biotechnology company that aims speeding up disease diagnosis and treatment.

OceanWell is a California-based water technology company on a mission to help end the water crisis and adapt to climate change.

Lomond Therapeutics creates pharmacological platforms that target escape mutations.

Dyania Health develops a research platform for pharma companies and hospital systems.

Terray Therapeutics is a Los Angeles-based biotechnology company that combines ultra-high throughput experimentation; generative AI; biology; medicinal chemistry; automation; and nanotechnology to exp

Riser Fitness operates Club Pilates and is dedicated to promoting health and wellness through the practice of Pilates.

FluidLogic designs and manufactures active hydration systems and accessories to promote healthier living.

Alterome Therapeutics; Inc. is an oncology Treatments founded in 2021 by Eric Murphy.

Abintus Bio; Inc. is a San Diego-based; preclinical stage gene therapy company focused on the discovery and development of a portfolio of product candidates that are designed to directly reprogram imm

Measured is a Santa Monica; California-based company.

Concert Health delivers behavioural health services inside primary care using the collaborative care model; embedding its own clinicians alongside medical groups and health systems so that depression

Molecular Assemblies; Inc. is an enzymatic DNA synthesis technology founded in 2013 by Curt Becker; Bill Efcavitch and William Efcavitch.

Jio Health is an Irvine; California-based company founded in 2011.

ImmunoVec; Inc. is a Santa Monica; California-based company founded in 2019.

A biotechnology company focused on the discovery and development of next-generation therapeutics.

GetLabs is a healthcare company.

Huckleberry provides paediatric sleep guidance for families with children up to five; pairing sleep experts and an app that builds personalised schedules from logged sleep data.

Clarify Medical is a developer of a handheld medical device used to treat psoriasis; eczema; and vitiligo .

Embodied; Inc. is a robotics and AI company creating companion robots for human-centric care and wellness.

Genomatica; which trades as Geno; is a San Diego industrial biotechnology company founded in 2000 by Christophe Schilling. It engineers micro-organisms and the bioprocesses around them so that widely

Kumquat Biosciences is a San Diego-based biotechnology company focused on the research and development of oncology medicines.

Nanocellect biomedical is a life science tools company manufacturing cell sorters using proprietary technology.

Aristea Therapeutics is a small Molecules founded in 2018.

Developer of therapeutic discovery quantum molecular simulation engine designed to accelerate molecular discovery.

Frame is a Santa Monica; California-based company founded by Kendall Bird.

Element Biosciences is a genetic analysis tools.