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SOUTHERN CALIFORNIA

Artificial Intelligence

The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.

105
companies
$2.71B
total raised
26
cities
Series G$1.19B
Shield AI Inc
San Diego, CA

Shield AI is a defense-tech company building the world's best AI pilots and next-generation aircraft.

Series GB2B
$325.4M
Iambic Therapeutics, Inc.
San Diego, CA · Founded 2019

Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.

Healthcare
$106.8M
RENOVARO INC.
Los Angeles, CA

Renovaro revolutionizes cancer and neurology care through early detection, drug discovery, and personalized treatments. AI-powered precision medicine.

Healthcare
Series B$94.4M
Cambium Biomaterials, Inc.
El Segundo, CA

Advanced material solutions—from AI-driven design to agile U.S. manufacturing—for defense, aerospace, & high-performance applications

Series BB2B
Series B$84.3M
Akido Labs
Los Angeles, CA · Founded 2014 · 1000 employees

Rebuilding healthcare with AI at the core

Y CombinatorSeries BHealthcare
Series B$80.3M
Pearl Inc.
West Hollywood, CA

FDA-cleared dental AI that detects 37% more disease. Join 29,000+ dental practices using Pearl's dental AI software. Book a demo.

Series BB2B
Series C$80.1M
Doppel Inc.
Covina, CA · Founded 2022

Outpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.

Series CB2B
Seed$71.0M
Enigma

Enigma is a physical AI startup building an intelligence layer for the robotics industry.

SeedIndustrials
Series B$54.5M
Placer Labs Inc.
Covina, CA

Make smarter real estate decisions and close more deals with Placer.ai's location intelligence and foot traffic insights.

Series BB2B
Series C$52.1M
Virtualitics, Inc.
Pasadena, CA

Virtualitics is an AI solutions company that transforms data into impactful action with AI readiness applications for defense, government, and enterprise.

Series CB2B
Series B$40.0M
Transcend Inc.
Covina, CA

Transcend is the only real-time data governance and decision layer that answers “Can I use this data?” to unblock AI, agentic, and first-party data initiatives.

Series BB2B
Series B$36.0M
Rabbit Inc/DE
Santa Monica, CA · Founded 2020

unlimited AI conversations, translation, and voice recordings — all in your $199 AI-native device rabbit r1, plus a chance to explore cutting-edge agents.

Series BB2B
Series A$32.1M
Brain Corp
San Diego, CA

Brain Corp is an autonomous technology company powering the most proven robots and AI, helping organizations create more productive and intelligent operations.

Series AB2B
Series B$32.0M
Human Longevity, Inc.
San Diego, CA

The most comprehensive executive health assessment — full-body MRI, whole genome sequencing, 120+ biomarkers & AI analysis in one visit. Starting at $8,000.

Series BHealthcare
Series A$28.9M
Vektor Medical, Inc.
San Diego, CA

Discover vMap - The FDA-Cleared Non-Invasive AI-based Arrhythmia Analysis Solution by Vektor Medical. Improve Cardiac Ablation Efficiencies & Outcomes Today.

Series AHealthcare
Series A$25.5M
KYG Trade, Inc.
Newport Beach, CA · Founded 2021

Enhance, extend or replace your legacy GTM software with affordable enterprise-grade AI-native trade and tariff management software from KYG Trade.

Series AB2B
Series B$25.5M
Mapped Inc.
El Segundo, CA · Founded 2019

Mapped turns any building's systems, sensors, and devices into a structured, real-time world model — the data foundation AI agents and applications need to understand and act on the physical world.

Series BB2B
Series C$24.5M
Foresee Medical, Inc.
San Diego, CA

AI-powered risk adjustment software designed to increase the profitability of Medicare risk contracts.

Series CHealthcare
Series A$23.2M
Quintessent Inc.
Goleta, CA · Founded 2019

Quintessent is developing optical connectivity solutions to scale computing and Artificial Intelligence (A.I.).

Series AB2B
Series B$22.0M
AgentAI Holdings, Inc.
Woodland Hills, CA · Founded 2025

Medical billing and revenue cycle management where AI agents carry every claim and expert billers fight the hard dollars. Free scan of your last 90 days.

Series BB2B
Series A$20.0M
ThinkBio.Ai, Inc
Ontario, CA · Founded 2024

ThinkBio.Ai is an AI-powered healthcare and life sciences solutions company, transforming complex data into actionable insights for better, faster decision-making.

Series AHealthcare
Series A$16.4M
Accrual, Inc.
Beverly Hills, CA · Founded 2024

Accrual transforms accounting firms with AI. Automate tax returns, streamline client data collection, and scale your practice with intelligent workflows.

Series AB2B
Series A$15.7M
Model Medicines, Inc.
La Jolla, CA · Founded 2019

Model Medicines engineers first-in-class small molecules against biological choke points, using AI to advance pipeline-in-a-pill therapeutics across high-impact diseases.

Series AHealthcare
Series A$15.0M
SWARM Engineering, Inc.
Irvine, CA

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.

Series AB2B
$15.0M
Cyber Wave X LLC
Los Angeles, CA · Founded 2025

Physical AI infrastructure from code to real world. Abstract with Digital Twins, plug in AI, and ship to production.

B2B
Series A$15.0M
North Beam, Inc.
El Segundo, CA

Multi-touch attribution and media mix modeling for profitable growth, powered by industry-leading machine learning models. Discover how Northbeam can transform your marketing.

Series AB2B
Series A$11.6M
Speakeasy Development, Inc.
Covina, CA · Founded 2022

The AI control plane for discovering, securing, and governing AI agents, MCP servers, and AI applications across your enterprise.

Series AB2B
Seed$10.4M
Sophia Space, Inc.
Pasadena, CA · Founded 2023

Orbital AI Edge Compute for Next-Gen Space Operations

SeedB2B
Series A$10.0M
AllVoices Holding Co.
Santa Monica, CA

AllVoices is the AI-native employee relations platform for anonymous reports, cases, and investigations. Save hours with AI case summaries and reports.

Series AB2B
Seed$9.4M
Verses AI Inc.
Los Angeles, CA · Founded 2020

Enterprise AI for finance that thinks and learns like people. VERSES Genius™ is used to manage risk when data is volatile, uncertain, complex & ambiguous.

SeedB2B
Series A$9.2M
Permissionless Labs, Inc.
Irvine, CA · Founded 2021

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.

Series AB2B
Seed$8.9M
Cognixion Corp
Santa Barbara, CA · Founded 2021

Cognixion develops accessible, non-invasive brain-computer interfaces combining neuroscience, AI, and spatial computing.

SeedB2B
Series A$8.3M
Jeeva AI, Inc.
Santa Monica, CA

Build, deploy, and govern autonomous digital workers across revenue, IT, service, and operations. Automate workflows, execute tasks, and scale work with AI-powered digital workers.

Series AB2B
$7.6M
PointOne Elise AI LLC
Manhattan Beach, CA · Founded 2025

EliseAI is the industry-leading AI platform transforming both property management and healthcare through automation and conversational AI that help housing and healthcare organizations streamline communications and improve operational efficiency.

B2B
Seed$7.2M
Stell Engineering, Inc.
Marina Del Rey, CA · Founded 2022

AI-native requirements management for engineers managing mission-critical compliance. Replace scattered docs and manual traceability with a single, audit-ready platform

SeedB2B
Seed$7.0M
Clout Kitchen Holdings Inc.
Los Angeles, CA · Founded 2026

Distribution marketing for music, entertainment, gaming, and brands. The AI Engine for virality, generating millions of views monthly.

SeedB2B
$6.8M
Ferret Systems Inc.
San Diego, CA

Search engines and social networks are not designed for due diligence. Ferret’s unparalleled AI platform combined with world class information provides you with exclusive relationship intelligence that can help you avoid high-risk individuals and spot promising opportunities.

B2B
Series A$6.7M
Qureator, Inc.
San Diego, CA

Qureator provides integrated human disease model and AI platform to evaluate treatment efficacy in complex disease models.

Series AHealthcare
Series A$6.0M
Cargofy Inc.
Covina, CA

AI workers that quote, dispatch, track, and close loads. Phone, email, WhatsApp. 28 languages, 24/7. Runs inside your TMS.

Series AB2B
Series A$5.6M
Eyenuk, Inc.
Woodland Hills, CA

EyeArt by Eyenuk is an autonomous, FDA-cleared AI for diabetic retinopathy screening and disease detection at the point of care.

Series AHealthcare
Series A$5.6M
Suma Wealth, Inc.
Santa Monica, CA

Meet Charlie, your AI financial coach inside the SUMA app. Get personalized budgeting, savings, and investing advice in English or Spanish.

Series AB2B
Seed$5.5M
Serenity EHS Inc.
San Diego, CA · Founded 2019

Serenity is a unified EHS platform built on ServiceNow for incident management, audits, risk assessments, compliance, and cyber risk — with AI-powered safety insights.

SeedB2B
Series A$5.4M
Ospitek, Inc.
San Diego, CA · Founded 2018

Ospitek empowers surgical centers with real-time IoT and AI-enhanced solutions, improving workflow efficiency, patient care, and staff coordination. Seamlessly integrate with legacy systems and unlock unparalleled operational visibility with Ospitek’s cutting-edge platform.

Series AHealthcare
Series A$5.0M
Wonder Dog Health, Inc.
Hermosa Beach, CA · Founded 2026

Preventive health platform for dogs. AI Health Companion, at-home blood draws & 40+ biomarker panel. Vet-built care plans for early disease detection.

Series AHealthcare
Series A$4.8M
Slips Technologies, Inc.
Los Angeles, CA

Slips is the next-generation peer-to-peer betting platform where players bet against each other — not the house. Offering Heads Up, Pools, Tourlays, and AI-Generated Predictions, Slips creates a social-first experience where users win, connect, and compete in real time.

Series AB2B
Series A$4.2M
Synaptec Health Inc.
Los Angeles, CA · Founded 2020

AI-driven medical coding from Synaptec Health - a more accurate, secure, and comprehensive solution for all your medical coding needs.

Series AHealthcare
$4.0M
Incentify Technologies, Inc.
El Segundo, CA · Founded 2025

Incentify is the platform for discovering and managing tax credits and incentives across 1,200+ federal, state, and zone programs with AI-powered eligibility matching and automated compliance tracking.

B2B
Series A$3.7M
Virgo Surgical Video Solutions, Inc.
Carlsbad, CA

Virgo builds frontier AI models to solve diseases mediated by the gut. Our flagship model, EndoDINO, was trained on the largest GI endoscopy dataset.

Series AHealthcare
Series C$3.7M
Certis Oncology Solutions, Inc.
San Diego, CA

Certis Oncology Intelligence: predictive AI + advanced cancer models for more insightful data. Translational science, done differently.

Series CHealthcare
Series A$2.9M
Pear Health Labs, Inc.
Carlsbad, CA · Founded 2022

Through its health & fitness AI platform, PEAR creates personalized digital coaching experiences to help people move smarter, get healthier, and live happier.

Series AB2B
Series A$2.8M
Respeecher, Inc.
Burbank, CA · Founded 2018

Professional AI voice generator for real production workflows, with free testing and flexible integration for studios and media teams.

Series AB2B
Seed$2.8M
Self Inspection Inc.
San Diego, CA · Founded 2021

Self Inspection uses AI trained on 20M+ images to automate vehicle damage detection, condition reports, and CR scoring — built for dealers, fleets, rentals, and lenders.

SeedB2B
Seed$2.5M
Spring Labs Holdings, Inc.
Marina Del Rey, CA · Founded 2025

AI-native agents for complaints, QA, and CX that help financial institutions automate compliance workflows and improve customer experience.

SeedB2B
Seed$2.3M
Moonware Inc.
Santa Monica, CA · Founded 2020

Moonware builds the AI systems that run ground operations. HALO, its Ground Traffic Control™ solution, gives airlines, handlers, and airports control over turnarounds, gate-in to gate-out.

SeedB2B
Seed$2.2M
Botcopy INC.
Los Angeles, CA

Deploy CX agents faster and safer with a stack built for public websites, service journeys, backend systems, and the realities that stall major AI launches.

SeedB2B
Seed$1.8M
Praxis Solutions, Inc.
West Hollywood, CA

An AI strategy and operations firm for wealth and asset managers. Built and run by senior operators.

SeedB2B
Series A$1.6M
InPractice, Inc.
Goleta, CA · Founded 2023

Review medical records in minutes, not days. Our AI-powered software creates instant summaries and chronologies so you can focus on what matters.

Series AB2B
Series A$1.4M
Bookitngo Corp
Irvine, CA · Founded 2021

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.

Series AB2B
Seed$1.1M
TRADESUN INC
Del Mar, CA

TradeSun is an innovator and leader in trade digitalization, financial crime prevention and sustainability scoring. We empower customers with our unique artificial intelligence solutions to confidently advance their global trade and supply chain processes, expanding economic prosperity for companies, countries and their people.

SeedB2B
Series B$1.0M
Nmblr, Inc.
El Segundo, CA · Founded 2023

NMBLR helps enterprises build, own, and scale AI across their organization. Get the foundation, capabilities, and systems to drive real outcomes with AI.

Series BB2B
Series B$900K
Bluon, Inc.
Irvine, CA

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.

Series BB2B
Series A$750K
Alderbuck Energy, Inc.
San Diego, CA · Founded 2024

Alderbuck Energy is modernizing power distribution with solid-state transformer technology built for the electricity demands of AI, EVs, and the modern grid.

Series AIndustrials
Series E$688K
Miso Robotics, Inc.
Pasadena, CA

Miso’s AI-powered kitchen automation platform to improve efficiency, reduce costs, and scale restaurant operations seamlessly.

Series EB2B
Seed$658K
Grin Gaming, Inc.
Venice, CA

GrinData micro markets software leverages best-in-class high-frequency trading and machine learning to deliver reliable odds pricing on the most markets. Brought to you by Grin Gaming.

SeedB2B
Series A$430K
SkillBench, Inc.
Santa Barbara, CA · Founded 2024

AI-enabled productivity and skill optimization for firms using Generative AI

Series AB2B
Seed$360K
ArcScore, Inc.
Studio City, CA · Founded 2025

ArcScore empowers athletes, schools, and brands with AI-driven insights to maximize NIL opportunities and build authentic partnerships.

SeedB2B
Series B$316K
LungLife AI, Inc.
Thousand Oaks, CA

LungLife AI is a diagnostic company focused on the early detection of lung cancer from a simple blood draw enhanced by artificial intelligence.

Series BHealthcare
Seed$300K
2X SOLUTIONS, LLC
Costa Mesa, CA · Founded 2023

AI phone agents that call, qualify, and route your leads in under a minute. Built-in CRM integrations for insurance, legal, financial, and medical businesses.

SeedB2B
Seed$270K
Leadoff.ai, Inc.
Los Angeles, CA · Founded 2023

Do Less, Win More With AI-Driven Sales Coaching

SeedB2B
Series A$170K
Site Bionics, Inc.
San Diego, CA · Founded 2023

Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.

Series AB2B
$154K
Solace Technologies Corp
Marina Del Rey, CA · Founded 2024

Solace is the real-time data platform for the enterprise — one platform that connects every application, cloud, partner, and edge, turns raw events into real-time context, and powers agentic AI in production.

B2B
Series D$125K
Wallabi, Inc.
San Diego, CA · Founded 2023

Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

Series DB2B
Seed$120K
Bristlecone Holdings, Inc.
Carlsbad, CA · Founded 2026

Bristlecone is the leading provider of connected logistics solutions, including AI applications, SAP integration, and more.

SeedB2B
Seed$100K
ARTIFICIAL GENIUS INC.
Venice, CA · Founded 2023

Explore Artificial Genius for cutting-edge AI solutions that redefine engineering and enhance enterprise productivity.

SeedB2B
Seed$75K
Cytodyme, Inc.
San Diego, CA · Founded 2024

AI-Enabled Quality and Regulatory Workflows

SeedB2B
Series F$70K
Guesty, Inc.
Covina, CA

Guesty is the AI-powered vacation rental software for short-term rental operators, from solo hosts to large portfolios.

Series FB2B
Series D$53K
Vincit California, Inc.
Irvine, CA

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

Series DB2B
Seed$45K
DoneCast, Inc.
Glendale, CA · Founded 2026

Record, edit with voice commands, and publish your podcast in minutes. DoneCast's AI handles filler removal, mistake correction, and professional mastering automatically.

SeedB2B
$45K
Loan Atlas Inc.
Thousand Oaks, CA · Founded 2023

The Loan Atlas installs five AI-powered systems into your mortgage business so you close more loans in less time, with less chaos.

B2B
$20K
Scientia Capital Solutions, Inc.
Irvine, CA · Founded 2025

Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.

B2B
Seed$20K
TurboPermit Corp
Santa Monica, CA · Founded 2024

TurboPermit helps residential builders and developers cut permit approval time by up to 50% with AI plan pre-check, digital forms, and one source of truth. Book a demo.

SeedB2B
Series A$725
Backplain, Inc.
Carlsbad, CA · Founded 2023

Multi-model AI with a patent-pending AI Firewall — for teams where data privacy is not optional. 47 models, one workspace, sensitive data stays home.

Series AB2B
MixerBox
Los Angeles, CA · Founded 2013 · 30 employees

AI Super-Apps to Live Easier | The anything anytime superapps…

Y CombinatorConsumer
Compose.ai
Carlsbad, CA · Founded 2021 · 7 employees

Cut your writing time by 40% with AI-powered autocomplete

Y CombinatorB2B
Korso
Irvine, CA · Founded 2026 · 3 employees

The AI-native agency

Y CombinatorB2B
Epsilon3
Los Angeles, CA · Founded 2021 · 12 employees

AI-Powered ERP, MES, and Test Software for Complex Operations

Y CombinatorB2B
Pirros
Los Angeles, CA · Founded 2022 · 44 employees

AI Platform for Architects and Engineers

Y CombinatorB2B
Atmeto
Los Angeles, CA · Founded 2023 · 2 employees

We develop ML that optimizes how batteries in the grid store energy

Y CombinatorIndustrials
Superunit
Los Angeles, CA · Founded 2024 · 5 employees

Faster, more profitable background checks with AI

Y CombinatorB2B
Relaw
Los Angeles, CA · Founded 2025 · 2 employees

AI Legal OS

Y CombinatorB2B
rct AI
Los Angeles, CA · Founded 2018 · 40 employees

build AI NPCs

Y CombinatorConsumer
Oda
Los Angeles, CA · Founded 2020 · 9 employees

AI Agent for Home Design

Y CombinatorB2B
Elythea
San Diego, CA · Founded 2023 · 2 employees

ML to predict and prevent pregnancy complications

Y CombinatorHealthcare
Grocalo
Los Angeles, CA · Founded 2026 · 0 employees

AI brain that runs content for creators

Y CombinatorConsumer
PARES AI
Los Angeles, CA · Founded 2025 · 3 employees

AI-native real estate services firm

Y CombinatorReal Estate and Construction
Legionfarm
Los Angeles, CA · Founded 2020 · 7 employees

AI workspace for professional gamers

Y CombinatorConsumer
Juicebox
Los Angeles, CA · Founded 2022 · 65 employees

AI-powered talent sourcing for recruiters

Y CombinatorB2B
AnythingLLM
Los Angeles, CA · Founded 2022 · 4 employees

Building the definitive all-in-one on-device AI productivity tool

Y CombinatorConsumer
Merlin AI
Los Angeles, CA · Founded 2024 · 19 employees

AI powered ERP for Construction

Y CombinatorB2B
Pixley AI
Los Angeles, CA · Founded 2025 · 2 employees

The first platform where families can create AI cartoons in minutes

Y CombinatorConsumer
Neuron Industries
Los Angeles, CA · Founded 2026 · 2 employees

Industrial Controllers built for AI

Y CombinatorIndustrials
Hemlock
Los Angeles, CA · Founded 2026 · 1 employees

Force-sensing wristband for training robotic AI

Y CombinatorIndustrials
Boumarang Inc.
Irvine, CA · Founded 2024

Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.

B2B
Absurd
Los Angeles, CA · Founded 2025 · 6 employees

The Creative OS for AI video

Y CombinatorB2B
FilmAI.tech, Inc.
Los Angeles, CA · Founded 2024

Using the Power of AI to Enhance Movies We control the digital rights to 5,000 Hollywood motion pictures and we have the option to license more. We are using the latest AI technology to enhance our film library as well as the films of other filmmakers. As veteran filmmakers, our mission is to use AI ... Read more

B2B
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