Artificial Intelligence startups in Southern California

Platform matching families with pediatric occupational therapy, physical therapy, and speech specialists, with AI billing automation. Serves LA, Orange County, and San Diego.

AI-native digital forensics and incident-response platform automating breach recovery for MSSPs, MSPs, and enterprises.

AI-guided robotic metal forming for automotive, aerospace, and defense manufacturing.

AI platform that generates code-compliant architectural, structural, and MEP construction documents from sketches, CAD files, or plain-language descriptions.

AI-powered operations app for real estate agents, covering comps, note-taking, and pipeline tracking.

AI platform unifying availability, pricing, and customer behavior data to help aftermarket auto-parts businesses optimize inventory and pricing.

Develops and operates AI-ready, build-to-suit, high-density data centers across North America and EMEA.

AI-powered digital curriculum platform helping K-12 schools fill teacher vacancies and improve graduation rates.

AI and human transformation partner for healthcare operations, serving providers and payers.

Smack Technologies is a frontier AI lab for national security that delivers decision dominance through proprietary, domain-specific models grounded in the physics of war and expert human priors.

FriskAI is a runtime observability and security platform for AI agents in production. It records structured traces of an agent's tool calls; arguments; outputs and timing; builds behavioural baselines

EdVisorly is a Los Angeles-based company founded in 2019 by Manny Smith.

Savi Security makes a consumer scam-protection app for iOS and Android that screens voicemail; monitors calls in real time and flags text spam; alongside a free scam-checking tool called Scamwise. It

Manifold Security provides runtime security for AI agents running on endpoints; monitoring what autonomous agents call and access rather than treating them as ordinary software.

Nominal is an AI-native B2B finance platform founded in 2022; offering a “shadow ledger” that automates accounting workflows; like consolidation; lease accounting; and close processes; to help mid-mar

Artera is a Santa Barbara agentic-healthcare company; founded in 2015; that provides AI-powered patient communications and care-navigation software for healthcare providers.

GammaTime is a short drama streaming app; distributing serialised vertical-video series through its mobile apps on a subscription basis.

Honey Health automates healthcare back-office work with AI; handling medical record requests; clinical operations and administrative fulfilment for providers.

Wolf Games builds AI-generated daily games that publishers and brands embed in their own sites: murder mysteries and puzzles generated from a customer's trending articles; refreshed every day; with st

Dialogue AI runs a customer research platform where AI moderates interviews and surveys at scale; conducting the conversations itself and then synthesising the qualitative material into structured fin

Planyear builds AI software for employee benefits consultants; automating the analysis and comparison of benefit plan documents and quotes.

Salt AI sells Salt OS; an AI workflow orchestration platform for regulated industries; life sciences; financial services; energy and government; that runs inside a customer's own infrastructure and is

Quilter uses physics-driven AI to automate printed circuit board layout; generating and validating board designs without manual routing.

PINC Technologies develops nonlinear photonics on a thin-film lithium niobate platform; targeting sensing; quantum and AI infrastructure applications.

Valence is a leadership and team-performance platform that uses AI coaching and continuous peer review to help enterprises improve how teams work together.

Divergent designs; prints and assembles complex metal structures on what it calls the Divergent Adaptive Production System (DAPS); an end-to-end line that runs from AI-driven generative design through

Sleep.ai; part of SleepScore Labs; provides B2B sleep intelligence solutions through APIs that power digital health; wellness; and consumer products. Originally founded in the Netherlands and later ac

FieldAI develops “Field Foundation Models;” physics-first AI that enables robots to operate autonomously in complex; real-world environments without GPS or maps. Serving industries like construction;

Rwazi is a Los Angeles-based B2B startup that delivers real-time; zero-party consumer data and insights to global brands. Leveraging AI and local networks; it helps companies track product usage; mark

2wai is a Los Angeles–based startup (founded 2024) building HoloAvatars: AI-powered conversational digital avatars that run entirely on users' devices.

Chronicle Studios is a B2B entertainment company using AI to develop and launch original franchises. Founded by industry veterans; it partners with creators to produce and market animated content; lev

AndrenaM builds AI-driven autonomous maritime systems for defense; founded by ex-SpaceX engineers.

Anduril builds AI platforms to protect troops; fight wildfires; perform search & rescue missions; and provide border surveillance. It was founded in 2017 and is located in Irvine; California.

Advanced AI video surveillance platform for municipalities and enterprises. AWS GovCloud certified; FedRAMP ready; and SOC 2 Type II compliant. Secure; scalable; and intelligent monitoring solutions.

Cheehoo is an AI-driven animation technology company revolutionizing 3D content creation. Founded by industry veterans; it offers tools that integrate with Maya and Unreal Engine; accelerating animati

Dosen is an AI-powered employee alignment platform founded in 2020 by Ronan Wall; Cian McCarthy and Victor Burke.

AI-driven tools provider for jewelers; designers; brands and retailers.

Uthana operates as a 3D character animation studio that uses generative AI.

Epirus builds Leonidas; a high-power microwave directed-energy system that disables drones with electromagnetic pulses rather than missiles; including while on the move. The company pitches it as a co

Zest AI is an AI lending technology company that leverages machine learning technology to enhance credit underwriting processes.

Lomond Therapeutics creates pharmacological platforms that target escape mutations.

Terray Therapeutics is a Los Angeles-based biotechnology company that combines ultra-high throughput experimentation; generative AI; biology; medicinal chemistry; automation; and nanotechnology to exp

Horizon Surgical Systems develops AI-driven; imaging-guided surgical robotics for microsurgery.

FluidLogic designs and manufactures active hydration systems and accessories to promote healthier living.

Sahara AI is a decentralized AI network that enables freely and securely deploy autonomous AI with high-performance; privacy-first network.

Wethos AI sells a decision-intelligence platform that adds human context to enterprise decision-making. It profiles individual leaders and teams across behavioural dimensions the company labels Ideas;

HeyGen is a Los Angeles-based company founded in 2020 by Joshua Xu.

Plai /plā/ (verb) : To engage in artificial intelligence for the purpose of enjoyment and recreation.

Zuum is an Irvine; California-based logistics company focusing on managing freight through AI technology.

Performa Labs; Inc. is an Irvine; California-based company founded in 2019.

An artificial intelligence company offering a call tracking and conversational analytics for marketers.

Genies builds AI-driven avatars and digital characters; letting creators and brands define a character's appearance; personality and backstory and then deploy it across games; fan experiences and soci

Theta Lake is a video classification startup dedicated to addressing the challenges organizations face in managing increasing video content and communication.

Snappt is a Los Angeles rental-fraud prevention software company founded in 2019 by Daniel Berlind and Noah Goldman. Its AI-powered Applicant Trust Platform combines document analysis; identity; incom

A biotechnology company focused on the discovery and development of next-generation therapeutics.

Kneron develops and provides edge AI-based integrated software and hardware for a variety of industries.

MosaicML is a San Francisco-based company offering a generative AI platform for enterprises to build their own AI systems.

Canvas built the first robotic drywall finishing system; a San Francisco construction-robotics company founded in 2017 whose 1200CX platform sprays and sands interior drywall to Level 4 and Level 5 fi

Embodied; Inc. is a robotics and AI company creating companion robots for human-centric care and wellness.

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