Artificial Intelligence startups in Southern California

Developer of therapeutic discovery quantum molecular simulation engine designed to accelerate molecular discovery.

Impact is an artificial Intelligence / Machine Learning company founded in 2002 by David Yovanno.

Seekops Inc. is a company founded in 2017.

Retina.AI is an AI-based early prediction of customer lifetime values founded in 2017 by Michael Greenberg; Emad Hasan and Brad Ito.

Blooma provides an AI platform for commercial real estate lenders; automating deal screening at origination and monitoring loan portfolios for risk.

GumGum is a Santa Monica; California-based developer of computer vision and machine learning systems for contextually driven advertising and brand protection.

Securonix delivers a security analytics and operations management platform for the modern era of big data and advanced cyber threats.

TuSimple is an autonomous commercial transportation company based in San Diego; CA.

Output is a United Kingdom-based company.

Beyond Limits is a Glendale; California-based company founded in 2014.

An artificial intelligence company that has a platform designed for professional networking. It was founded in 2017 and is located in California.

Developer of a camera-based AI system designed to offer automated store services. The company's system helps shoppers to enter a store; pick the items they want; then walk out; receiving a receipt via

FanAI is an AI-driven audience monetization platform focusing on esports; its sponsor ecosystem; increasing sponsorship revenues; and making fan data actionable

FlightWave Aerospace is a Santa Monica; California-based company founded in 2014 by Michael Colonno.

PetDesk sells practice software to veterinary clinics. It covers client communication and reminders; online booking; an integrated phone system; AI-generated clinical notes and marketing; and is aimed

Pathmatics provides AI-powered analytics software for marketers that can extract data about various channels; including social media; video; and display.

Citadel builds an automated and modular drone defense system that uses machine learning algorithms to detect and engage drones.

ObEN is a Pasadena; California-based artificial intelligence company.

DeepRadiology Corp is a medical artificial intelligence company.

Nervana Systems was a San Diego-based company focused on the development of artificial intelligence and deep learning software. The company was acquired by Intel in 2016.

Shield AI is a defense-tech company building the world's best AI pilots and next-generation aircraft.

Mirador Therapeutics is focused on discovering and developing precision medicines for immune-mediated inflammatory and fibrotic diseases using its Mirador360™ engine, which harnesses biology, multi-modal data, AI, and advanced analytics.

Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.

Renovaro revolutionizes cancer and neurology care through early detection, drug discovery, and personalized treatments. AI-powered precision medicine.

Advanced material solutions—from AI-driven design to agile U.S. manufacturing—for defense, aerospace, & high-performance applications

Rebuilding healthcare with AI at the core

FDA-cleared dental AI that detects 37% more disease. Join 29,000+ dental practices using Pearl's dental AI software. Book a demo.

Outpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.

ProrataAI, Inc. builds AI-powered search, advertising, and attribution solutions that respect content creators and publishers by ensuring transparent crediting and equitable value sharing.

HiveWatch provides a platform that unifies physical security systems into one AI-powered command center to help security teams prioritize incidents and automate responses.

Make smarter real estate decisions and close more deals with Placer.ai's location intelligence and foot traffic insights.

Virtualitics is an AI solutions company that transforms data into impactful action with AI readiness applications for defense, government, and enterprise.

Transcend is the only real-time data governance and decision layer that answers “Can I use this data?” to unblock AI, agentic, and first-party data initiatives.

unlimited AI conversations, translation, and voice recordings — all in your $199 AI-native device rabbit r1, plus a chance to explore cutting-edge agents.

Brain Corp is an autonomous technology company powering the most proven robots and AI, helping organizations create more productive and intelligent operations.

The most comprehensive executive health assessment — full-body MRI, whole genome sequencing, 120+ biomarkers & AI analysis in one visit. Starting at $8,000.

Discover vMap - The FDA-Cleared Non-Invasive AI-based Arrhythmia Analysis Solution by Vektor Medical. Improve Cardiac Ablation Efficiencies & Outcomes Today.

GATC Health is a tech-bio company that uses proprietary AI to accelerate and de-risk the discovery and development of safer and more effective drugs for biopharma companies and investors.

Enhance, extend or replace your legacy GTM software with affordable enterprise-grade AI-native trade and tariff management software from KYG Trade.

Mapped turns any building's systems, sensors, and devices into a structured, real-time world model — the data foundation AI agents and applications need to understand and act on the physical world.

AI-powered risk adjustment software designed to increase the profitability of Medicare risk contracts.

Quintessent is developing optical connectivity solutions to scale computing and Artificial Intelligence (A.I.).

Uplifting Results Labs, Inc. provides AI 3D motion capture technology for sports performance, sports medicine, and sports media, utilizing smartphone technology for biomechanical analysis.

Medical billing and revenue cycle management where AI agents carry every claim and expert billers fight the hard dollars. Free scan of your last 90 days.

ThinkBio.Ai is an AI-powered healthcare and life sciences solutions company, transforming complex data into actionable insights for better, faster decision-making.

Athos Therapeutics Inc. is a clinical stage biotechnology company that pioneers the development of artificial intelligence-based Precision Therapeutics for patients with Inflammatory Bowel Disease and other inflammatory diseases.

Accrual transforms accounting firms with AI. Automate tax returns, streamline client data collection, and scale your practice with intelligent workflows.

Mixed-Signal Devices Inc. delivers multi-gigahertz digital timing solutions with ultra-low jitter, stability, and programmability for AI infrastructure, 5G networks, and high-performance automotive platforms.

Model Medicines engineers first-in-class small molecules against biological choke points, using AI to advance pipeline-in-a-pill therapeutics across high-impact diseases.

Radical Group Inc. helps businesses unlock their full potential through integrated solutions in Data, AI, Digital Design, and Training.

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.

Physical AI infrastructure from code to real world. Abstract with Digital Twins, plug in AI, and ship to production.

Multi-touch attribution and media mix modeling for profitable growth, powered by industry-leading machine learning models. Discover how Northbeam can transform your marketing.

Develo Inc. provides AI-native pediatric software built as an operating system for charting, billing, practice management, and family experience for independent pediatric practices.

The AI control plane for discovering, securing, and governing AI agents, MCP servers, and AI applications across your enterprise.

RCE Technologies is developing Infrasensor™, a non-invasive wearable that uses infrared spectroscopy and machine learning to detect severe coronary artery occlusion in about three minutes, without a blood draw — aimed at catching the 60%+ of heart attacks that standard chest-pain triage misses.

Orbital AI Edge Compute for Next-Gen Space Operations

NB Tech Acquisitions Corp is a California-based company that acquires and develops code-based technology, focusing on high-growth sectors like artificial intelligence, cyber security, and decentralized technologies.

AllVoices is the AI-native employee relations platform for anonymous reports, cases, and investigations. Save hours with AI case summaries and reports.

Avicena, LLC develops microLED-based optical interconnects for high-speed communications, enabling energy-efficient AI data centers and GPU clusters to scale up.