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Artificial Intelligence startups in Southern California

The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.

255
companies
$13.35B
total raised
39
cities

Companies

Xano, Inc. hero photo
Seed$10.0M
Xano, Inc.
Woodland Hills, CA

Xano offers a scalable no-code backend and provides professional backend development for the AI era, enabling users to understand, govern, and run AI-built software.

SeedB2B
Verses AI Inc. hero photo
Seed$9.4M
Verses AI Inc.
Los Angeles, CA · Founded 2020

Enterprise AI for finance that thinks and learns like people. VERSES Genius™ is used to manage risk when data is volatile, uncertain, complex & ambiguous.

SeedB2B
Permissionless Labs, Inc. hero photo
Series A$9.2M
Permissionless Labs, Inc.
Irvine, CA · Founded 2021 · ~11-50 employees

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.

Series AB2B
Cognixion Corp hero photo
Seed$8.9M
Cognixion Corp
Santa Barbara, CA · Founded 2021

Cognixion develops accessible, non-invasive brain-computer interfaces combining neuroscience, AI, and spatial computing.

SeedB2B
Jeeva AI, Inc. hero photo
Series A$8.3M
Jeeva AI, Inc.
Santa Monica, CA

Build, deploy, and govern autonomous digital workers across revenue, IT, service, and operations. Automate workflows, execute tasks, and scale work with AI-powered digital workers.

Series AB2B
$7.6M
PointOne Elise AI LLC
Manhattan Beach, CA · Founded 2025

EliseAI is the industry-leading AI platform transforming both property management and healthcare through automation and conversational AI that help housing and healthcare organizations streamline communications and improve operational efficiency.

B2B
Stell Engineering, Inc. hero photo
Seed$7.2M
Stell Engineering, Inc.
Marina Del Rey, CA · Founded 2022

AI-native requirements management for engineers managing mission-critical compliance. Replace scattered docs and manual traceability with a single, audit-ready platform

SeedB2B
Clout Kitchen Holdings Inc. hero photo
Seed$7.0M
Clout Kitchen Holdings Inc.
Los Angeles, CA · Founded 2026

Distribution marketing for music, entertainment, gaming, and brands. The AI Engine for virality, generating millions of views monthly.

SeedB2B
$6.8M
Ferret Systems Inc.
San Diego, CA

Search engines and social networks are not designed for due diligence. Ferret’s unparalleled AI platform combined with world class information provides you with exclusive relationship intelligence that can help you avoid high-risk individuals and spot promising opportunities.

B2B
Oxen Labs Inc. hero photo
$6.7M
Oxen Labs Inc.
Santa Monica, CA · Founded 2022

Oxen.ai provides an AI platform for creators and builders, offering tools to generate videos and images, brainstorm with LLMs, organize asset libraries, and deploy custom fine-tuned endpoints.

B2B
Series A$6.7M
Qureator, Inc.
San Diego, CA

Qureator provides integrated human disease model and AI platform to evaluate treatment efficacy in complex disease models.

Series AHealthcare
Cargofy Inc. hero photo
Series A$6.0M
Cargofy Inc.
Covina, CA

AI workers that quote, dispatch, track, and close loads. Phone, email, WhatsApp. 28 languages, 24/7. Runs inside your TMS.

Series AB2B
Eyenuk, Inc. hero photo
Series A$5.6M
Eyenuk, Inc.
Woodland Hills, CA

EyeArt by Eyenuk is an autonomous, FDA-cleared AI for diabetic retinopathy screening and disease detection at the point of care.

Series AHealthcare
Suma Wealth, Inc. hero photo
Series A$5.6M
Suma Wealth, Inc.
Santa Monica, CA

Meet Charlie, your AI financial coach inside the SUMA app. Get personalized budgeting, savings, and investing advice in English or Spanish.

Series AB2B
Serenity EHS Inc. hero photo
Seed$5.5M
Serenity EHS Inc.
San Diego, CA · Founded 2019

Serenity is a unified EHS platform built on ServiceNow for incident management, audits, risk assessments, compliance, and cyber risk — with AI-powered safety insights.

SeedB2B
Ospitek, Inc. hero photo
Series A$5.4M
Ospitek, Inc.
San Diego, CA · Founded 2018

Ospitek empowers surgical centers with real-time IoT and AI-enhanced solutions, improving workflow efficiency, patient care, and staff coordination. Seamlessly integrate with legacy systems and unlock unparalleled operational visibility with Ospitek’s cutting-edge platform.

Series AHealthcare
Seed$5.2M
Concrete AI, Inc.
Santa Monica, CA · Founded 2021

Concrete AI's Concrete Copilot delivers concrete producers a simple, fast, and flexible decision-making tool to optimize concrete performance, cost-savings, and carbon reductions with AI-assisted concrete designs.

SeedB2B
Wonder Dog Health, Inc. hero photo
Series A$5.0M
Wonder Dog Health, Inc.
Hermosa Beach, CA · Founded 2026

Preventive health platform for dogs. AI Health Companion, at-home blood draws & 40+ biomarker panel. Vet-built care plans for early disease detection.

Series AHealthcare
Slips Technologies, Inc. hero photo
Series A$4.8M
Slips Technologies, Inc.
Los Angeles, CA

Slips is the next-generation peer-to-peer betting platform where players bet against each other — not the house. Offering Heads Up, Pools, Tourlays, and AI-Generated Predictions, Slips creates a social-first experience where users win, connect, and compete in real time.

Series AB2B
Synaptec Health Inc. hero photo
Series A$4.2M
Synaptec Health Inc.
Los Angeles, CA · Founded 2020

AI-driven medical coding from Synaptec Health - a more accurate, secure, and comprehensive solution for all your medical coding needs.

Series AHealthcare
PiLogic Inc. hero photo
Seed$4.1M
PiLogic Inc.
Los Angeles, CA · Founded 2024

PiLogic is a dual-use company that revolutionizes aerospace by delivering precise, efficient, and mathematically grounded AI solutions for critical dual-use aerospace applications like tracking, diagnosis, and sensor fusion.

SeedB2B
Series A$4.0M
F42 Corp
Newport Beach, CA · Founded 2026

F42 Corporation is a vertically integrated AI infrastructure company combining sovereign-grade renewable power, world-class data center capacity, and an elite applied-AI engineering workforce for Tier 1 government and enterprise clients.

Series AB2B
Incentify Technologies, Inc. hero photo
$4.0M
Incentify Technologies, Inc.
El Segundo, CA · Founded 2025

Incentify is the platform for discovering and managing tax credits and incentives across 1,200+ federal, state, and zone programs with AI-powered eligibility matching and automated compliance tracking.

B2B
Virgo Surgical Video Solutions, Inc. hero photo
Series A$3.7M
Virgo Surgical Video Solutions, Inc.
Carlsbad, CA

Virgo builds frontier AI models to solve diseases mediated by the gut. Our flagship model, EndoDINO, was trained on the largest GI endoscopy dataset.

Series AHealthcare
Certis Oncology Solutions, Inc. hero photo
$3.7M
Certis Oncology Solutions, Inc.
San Diego, CA · ~11-50 employees

Certis Oncology Intelligence: predictive AI + advanced cancer models for more insightful data. Translational science, done differently.

Healthcare
ProCode Inc. hero photo
Series A$3.6M
ProCode Inc.
Los Angeles, CA · Founded 2024 · ~51-200 employees

ProCode Inc. provides an AI-Powered Medical Billing & Coding Copilot.

Series AB2B
Pre-Seed$3.3M
RiskFront, Inc.
Los Angeles, CA · Founded 2024

RiskFront provides an AI-enabled risk operating system called AIROS for financial crime risk and compliance operational tasks and workflows, consisting of three Agentic AI Systems: Due Diligence Research (DDR), Transaction Analysis (TXA), and Document Analysis (DXA).

Pre-SeedB2B
Seed$3.0M
AgBlox, Inc.
Irvine, CA · Founded 2019

AgBlox is an AI platform that predicts agricultural commodity prices.

SeedB2B
Pre-Seed$2.9M
SuperTrader, Inc.
Los Angeles, CA · Founded 2020 · ~11-50 employees

SuperTrader is an AI trading journal built by traders that helps users trade better by finding time-of-day biases, streak tilts, and broken rules, turning losses into feedback.

Pre-SeedFintech
Series A$2.9M
Pear Health Labs, Inc.
Carlsbad, CA · Founded 2022

Through its health & fitness AI platform, PEAR creates personalized digital coaching experiences to help people move smarter, get healthier, and live happier.

Series AB2B
Respeecher, Inc. hero photo
Series A$2.8M
Respeecher, Inc.
Burbank, CA · Founded 2018

Professional AI voice generator for real production workflows, with free testing and flexible integration for studios and media teams.

Series AB2B
Self Inspection Inc. hero photo
Seed$2.8M
Self Inspection Inc.
San Diego, CA · Founded 2021

Self Inspection uses AI trained on 20M+ images to automate vehicle damage detection, condition reports, and CR scoring — built for dealers, fleets, rentals, and lenders.

SeedB2B
Seed$2.5M
Spring Labs Holdings, Inc.
Marina Del Rey, CA · Founded 2025

AI-native agents for complaints, QA, and CX that help financial institutions automate compliance workflows and improve customer experience.

SeedB2B
Moonware Inc. hero photo
Seed$2.3M
Moonware Inc.
Santa Monica, CA · Founded 2020

Moonware builds the AI systems that run ground operations. HALO, its Ground Traffic Control™ solution, gives airlines, handlers, and airports control over turnarounds, gate-in to gate-out.

SeedB2B
Seed$2.2M
Botcopy INC.
Los Angeles, CA

Deploy CX agents faster and safer with a stack built for public websites, service journeys, backend systems, and the realities that stall major AI launches.

SeedB2B
Seed$2.2M
Atmosphere DC Holdings LLC
Newport Beach, CA · Founded 2024

Atmosphere DC Holdings LLC provides data centers and AI factories that are designed for AI, ML, cloud, and enterprise workloads, with a focus on sustainability, innovation, and efficiency.

SeedB2B
Pre-Seed$2.0M
MoveJoy, Inc
El Segundo, CA · Founded 2023

MoveJoy, Inc. provides an AI receptionist service for movers that quotes, books, and closes jobs.

Pre-SeedB2B
Seed$2.0M
Lucendi, Inc.
Los Angeles, CA

Lucendi develops AI-enabled smart measurement systems that redefine micro-object characterization through cost-effective and high-performance computational microscopy technology coupled with big data and machine learning.

SeedB2B
$2.0M
Adaya AI, Inc.
Santa Barbara, CA · Founded 2022

Adaya invents AI products and builds every layer of them end to end, including the model, the agent, and the design.

B2B
Praxis Solutions, Inc. hero photo
Seed$1.8M
Praxis Solutions, Inc.
West Hollywood, CA

An AI strategy and operations firm for wealth and asset managers. Built and run by senior operators.

SeedB2B
Farmsense Inc. hero photo
Seed$1.7M
Farmsense Inc.
Riverside, CA

FarmSense provides automated digital 24/7 pest monitoring for growers using novel patented FlightSensors and an AI cloud-based Machine Learning Engine to detect and classify multiple pest species in various crops.

SeedIndustrials
Series A$1.6M
InPractice, Inc.
Goleta, CA · Founded 2023

Review medical records in minutes, not days. Our AI-powered software creates instant summaries and chronologies so you can focus on what matters.

Series AB2B
Metaverse Rights, Inc. hero photo
$1.6M
Metaverse Rights, Inc.
Los Angeles, CA · Founded 2021

Metaverse Law is a law firm that exclusively focuses on Privacy, AI, and Cybersecurity Law, helping companies navigate data protection, AI governance, risk, and compliance challenges across the digital economy.

B2B
Seed$1.5M
CancerVAX, Inc.
Santa Barbara, CA · Founded 2021

CancerVax is a pre-clinical biotech company developing a novel Universal Cancer Treatment Platform that uses artificial intelligence to disguise cancer cells to look like measles, thereby tricking the body's immune system into killing them.

SeedHealthcare
Looq.ai hero photo
Seed$1.5M
Looq.ai
San Diego, CA · Founded 2021

Looq.ai builds an AI handheld photogrammetry platform (qCam/qAI/qApp) for 3D land and utility surveying.

SeedB2B
Bookitngo Corp hero photo
Series A$1.4M
Bookitngo Corp
Irvine, CA · Founded 2021 · ~11-50 employees

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.

Series AB2B
Series A$1.2M
Yatiri Bio, Inc.
San Diego, CA · Founded 2021

Yatiri Bio, Inc. is re-enisioning the pharmaceutical industry's current drug discovery process by integrating patient data sets with testable empirical models to guide patient selection and clinical development, utilizing advanced proteomics and bioinformatics tools and deep learning models.

Series AB2B
TRADESUN INC hero photo
Seed$1.1M
TRADESUN INC
Del Mar, CA

TradeSun is an innovator and leader in trade digitalization, financial crime prevention and sustainability scoring. We empower customers with our unique artificial intelligence solutions to confidently advance their global trade and supply chain processes, expanding economic prosperity for companies, countries and their people.

SeedB2B
Nmblr, Inc. hero photo
$1.0M
Nmblr, Inc.
El Segundo, CA · Founded 2023

NMBLR helps enterprises build, own, and scale AI across their organization. Get the foundation, capabilities, and systems to drive real outcomes with AI.

B2B
Bluon, Inc. hero photo
$900K
Bluon, Inc.
Irvine, CA

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.

B2B
GenseeAI Inc. hero photo
$750K
GenseeAI Inc.
San Diego, CA · Founded 2024

Gensee builds practical control infrastructure for AI operating across real developer and production environments by evaluating AI requests, granting narrowly scoped authority, mediating privileged effects, and recording what actually happened.

B2B
Series A$750K
Alderbuck Energy, Inc.
San Diego, CA · Founded 2024

Alderbuck Energy is modernizing power distribution with solid-state transformer technology built for the electricity demands of AI, EVs, and the modern grid.

Series AIndustrials
Bot Mediation, Inc. hero photo
Pre-Seed$695K
Bot Mediation, Inc.
Costa Mesa, CA · Founded 2023

Bot Mediation offers plaintiffs and defendants an AI-powered solution to resolve legal disputes through mediation.

Pre-SeedB2B
Miso Robotics, Inc. hero photo
$688K
Miso Robotics, Inc.
Pasadena, CA

Miso’s AI-powered kitchen automation platform to improve efficiency, reduce costs, and scale restaurant operations seamlessly.

B2B
Seed$670K
LenderSquared, inc
Carlsbad, CA · Founded 2025

LenderSquared provides a Unified Intelligence Platform that integrates data, AI, and analytics to help modern lenders evaluate risk, automate workflows, and fund faster with clarity and control.

SeedB2B
Grin Gaming, Inc. hero photo
Seed$658K
Grin Gaming, Inc.
Venice, CA

GrinData micro markets software leverages best-in-class high-frequency trading and machine learning to deliver reliable odds pricing on the most markets. Brought to you by Grin Gaming.

SeedB2B
Novella AI, Inc hero photo
Seed$499K
Novella AI, Inc
Ventura, CA · Founded 2023

Novella AI, Inc offers Ella, an AI Video Platform that allows creators to write, generate, and edit cinematic videos using AI models.

SeedB2B
Edit Hero, Inc. hero photo
Seed$460K
Edit Hero, Inc.
Encino, CA · Founded 2021

EditHero streamlines post-production with AI-driven tools for sequence alignment, version comparison, and faster video finishing.

SeedB2B
SkillBench, Inc. hero photo
$430K
SkillBench, Inc.
Santa Barbara, CA · Founded 2024

AI-enabled productivity and skill optimization for firms using Generative AI

B2B
Seed$395K
RANKED MEDIA, INC.
Sherman Oaks, CA

Ranked is an AI-powered engine and activation platform that deploys experts and creators to deliver authentic engagement for brands and to empower democracy by connecting local, expert creators who share important videos about their local communities.

SeedB2B