Artificial Intelligence startups in Southern California
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Companies

Xano offers a scalable no-code backend and provides professional backend development for the AI era, enabling users to understand, govern, and run AI-built software.
Enterprise AI for finance that thinks and learns like people. VERSES Genius™ is used to manage risk when data is volatile, uncertain, complex & ambiguous.

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.

Cognixion develops accessible, non-invasive brain-computer interfaces combining neuroscience, AI, and spatial computing.

Build, deploy, and govern autonomous digital workers across revenue, IT, service, and operations. Automate workflows, execute tasks, and scale work with AI-powered digital workers.
EliseAI is the industry-leading AI platform transforming both property management and healthcare through automation and conversational AI that help housing and healthcare organizations streamline communications and improve operational efficiency.

AI-native requirements management for engineers managing mission-critical compliance. Replace scattered docs and manual traceability with a single, audit-ready platform
Distribution marketing for music, entertainment, gaming, and brands. The AI Engine for virality, generating millions of views monthly.
Search engines and social networks are not designed for due diligence. Ferret’s unparalleled AI platform combined with world class information provides you with exclusive relationship intelligence that can help you avoid high-risk individuals and spot promising opportunities.
Oxen.ai provides an AI platform for creators and builders, offering tools to generate videos and images, brainstorm with LLMs, organize asset libraries, and deploy custom fine-tuned endpoints.
Qureator provides integrated human disease model and AI platform to evaluate treatment efficacy in complex disease models.

AI workers that quote, dispatch, track, and close loads. Phone, email, WhatsApp. 28 languages, 24/7. Runs inside your TMS.

EyeArt by Eyenuk is an autonomous, FDA-cleared AI for diabetic retinopathy screening and disease detection at the point of care.

Meet Charlie, your AI financial coach inside the SUMA app. Get personalized budgeting, savings, and investing advice in English or Spanish.

Serenity is a unified EHS platform built on ServiceNow for incident management, audits, risk assessments, compliance, and cyber risk — with AI-powered safety insights.

Ospitek empowers surgical centers with real-time IoT and AI-enhanced solutions, improving workflow efficiency, patient care, and staff coordination. Seamlessly integrate with legacy systems and unlock unparalleled operational visibility with Ospitek’s cutting-edge platform.
Concrete AI's Concrete Copilot delivers concrete producers a simple, fast, and flexible decision-making tool to optimize concrete performance, cost-savings, and carbon reductions with AI-assisted concrete designs.

Preventive health platform for dogs. AI Health Companion, at-home blood draws & 40+ biomarker panel. Vet-built care plans for early disease detection.

Slips is the next-generation peer-to-peer betting platform where players bet against each other — not the house. Offering Heads Up, Pools, Tourlays, and AI-Generated Predictions, Slips creates a social-first experience where users win, connect, and compete in real time.

AI-driven medical coding from Synaptec Health - a more accurate, secure, and comprehensive solution for all your medical coding needs.

PiLogic is a dual-use company that revolutionizes aerospace by delivering precise, efficient, and mathematically grounded AI solutions for critical dual-use aerospace applications like tracking, diagnosis, and sensor fusion.
F42 Corporation is a vertically integrated AI infrastructure company combining sovereign-grade renewable power, world-class data center capacity, and an elite applied-AI engineering workforce for Tier 1 government and enterprise clients.
.png&w=3840&q=75)
Incentify is the platform for discovering and managing tax credits and incentives across 1,200+ federal, state, and zone programs with AI-powered eligibility matching and automated compliance tracking.

Virgo builds frontier AI models to solve diseases mediated by the gut. Our flagship model, EndoDINO, was trained on the largest GI endoscopy dataset.

Certis Oncology Intelligence: predictive AI + advanced cancer models for more insightful data. Translational science, done differently.

ProCode Inc. provides an AI-Powered Medical Billing & Coding Copilot.
RiskFront provides an AI-enabled risk operating system called AIROS for financial crime risk and compliance operational tasks and workflows, consisting of three Agentic AI Systems: Due Diligence Research (DDR), Transaction Analysis (TXA), and Document Analysis (DXA).
AgBlox is an AI platform that predicts agricultural commodity prices.
SuperTrader is an AI trading journal built by traders that helps users trade better by finding time-of-day biases, streak tilts, and broken rules, turning losses into feedback.
Through its health & fitness AI platform, PEAR creates personalized digital coaching experiences to help people move smarter, get healthier, and live happier.

Professional AI voice generator for real production workflows, with free testing and flexible integration for studios and media teams.

Self Inspection uses AI trained on 20M+ images to automate vehicle damage detection, condition reports, and CR scoring — built for dealers, fleets, rentals, and lenders.
AI-native agents for complaints, QA, and CX that help financial institutions automate compliance workflows and improve customer experience.

Moonware builds the AI systems that run ground operations. HALO, its Ground Traffic Control™ solution, gives airlines, handlers, and airports control over turnarounds, gate-in to gate-out.
Deploy CX agents faster and safer with a stack built for public websites, service journeys, backend systems, and the realities that stall major AI launches.
Atmosphere DC Holdings LLC provides data centers and AI factories that are designed for AI, ML, cloud, and enterprise workloads, with a focus on sustainability, innovation, and efficiency.
MoveJoy, Inc. provides an AI receptionist service for movers that quotes, books, and closes jobs.
Lucendi develops AI-enabled smart measurement systems that redefine micro-object characterization through cost-effective and high-performance computational microscopy technology coupled with big data and machine learning.
Adaya invents AI products and builds every layer of them end to end, including the model, the agent, and the design.
An AI strategy and operations firm for wealth and asset managers. Built and run by senior operators.

FarmSense provides automated digital 24/7 pest monitoring for growers using novel patented FlightSensors and an AI cloud-based Machine Learning Engine to detect and classify multiple pest species in various crops.
Review medical records in minutes, not days. Our AI-powered software creates instant summaries and chronologies so you can focus on what matters.
Metaverse Law is a law firm that exclusively focuses on Privacy, AI, and Cybersecurity Law, helping companies navigate data protection, AI governance, risk, and compliance challenges across the digital economy.
CancerVax is a pre-clinical biotech company developing a novel Universal Cancer Treatment Platform that uses artificial intelligence to disguise cancer cells to look like measles, thereby tricking the body's immune system into killing them.

Looq.ai builds an AI handheld photogrammetry platform (qCam/qAI/qApp) for 3D land and utility surveying.

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.
Yatiri Bio, Inc. is re-enisioning the pharmaceutical industry's current drug discovery process by integrating patient data sets with testable empirical models to guide patient selection and clinical development, utilizing advanced proteomics and bioinformatics tools and deep learning models.

TradeSun is an innovator and leader in trade digitalization, financial crime prevention and sustainability scoring. We empower customers with our unique artificial intelligence solutions to confidently advance their global trade and supply chain processes, expanding economic prosperity for companies, countries and their people.

NMBLR helps enterprises build, own, and scale AI across their organization. Get the foundation, capabilities, and systems to drive real outcomes with AI.

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.

Gensee builds practical control infrastructure for AI operating across real developer and production environments by evaluating AI requests, granting narrowly scoped authority, mediating privileged effects, and recording what actually happened.
Alderbuck Energy is modernizing power distribution with solid-state transformer technology built for the electricity demands of AI, EVs, and the modern grid.

Bot Mediation offers plaintiffs and defendants an AI-powered solution to resolve legal disputes through mediation.

Miso’s AI-powered kitchen automation platform to improve efficiency, reduce costs, and scale restaurant operations seamlessly.
LenderSquared provides a Unified Intelligence Platform that integrates data, AI, and analytics to help modern lenders evaluate risk, automate workflows, and fund faster with clarity and control.

GrinData micro markets software leverages best-in-class high-frequency trading and machine learning to deliver reliable odds pricing on the most markets. Brought to you by Grin Gaming.

Novella AI, Inc offers Ella, an AI Video Platform that allows creators to write, generate, and edit cinematic videos using AI models.

EditHero streamlines post-production with AI-driven tools for sequence alignment, version comparison, and faster video finishing.
AI-enabled productivity and skill optimization for firms using Generative AI
Ranked is an AI-powered engine and activation platform that deploys experts and creators to deliver authentic engagement for brands and to empower democracy by connecting local, expert creators who share important videos about their local communities.