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Artificial Intelligence startups in Southern California

The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.

255
companies
$13.35B
total raised
39
cities

Companies

Seed$360K
ArcScore, Inc.
Studio City, CA · Founded 2025

ArcScore empowers athletes, schools, and brands with AI-driven insights to maximize NIL opportunities and build authentic partnerships.

SeedB2B
$316K
LungLife AI, Inc.
Thousand Oaks, CA · ~11-50 employees

LungLife AI is a diagnostic company focused on the early detection of lung cancer from a simple blood draw enhanced by artificial intelligence.

Healthcare
Alto Labs LLC hero photo
$300K
Alto Labs LLC
Los Angeles, CA · Founded 2023

Altolabs Inc. provides AI solutions for enterprises, designed for accountability, data residency, and full control over how intelligence is governed and deployed.

Healthcare
SuperMem Inc. hero photo
Seed$300K
SuperMem Inc.
San Diego, CA · Founded 2019

SuperMem GrowthOS pairs AI speed with human judgment to provide growth solutions, with real operators closing what AI cannot.

SeedB2B
Seed$300K
2X SOLUTIONS, LLC
Costa Mesa, CA · Founded 2023

AI phone agents that call, qualify, and route your leads in under a minute. Built-in CRM integrations for insurance, legal, financial, and medical businesses.

SeedB2B
EFAS Technologies, Inc. hero photo
Seed$275K
EFAS Technologies, Inc.
Newport Beach, CA · Founded 2023

EFAS Technologies revolutionizes water leak detection with its groundbreaking solution, the Global AI Leak Locator (GAILL), which uses AI-Powered Software for Detecting & Localizing Anomalies in Water Systems.

SeedB2B
Seed$270K
Leadoff.ai, Inc.
Los Angeles, CA · Founded 2023

Do Less, Win More With AI-Driven Sales Coaching

SeedB2B
Simonn Inc hero photo
$250K
Simonn Inc
Los Angeles, CA · Founded 2025

Simon AI is an agentic marketing platform with an AI-first CDP that helps marketers create personalized campaigns grounded in live customer data and real-world signals.

B2B
Seed$250K
Deepcast, Inc.
Los Angeles, CA · Founded 2023

DeepCast, Inc. provides an AI SaaS platform that helps engineers and scientists build practical models, integrate diverse data sources and tools, and create digital twins for product development.

SeedB2B
UFLO1, INC. hero photo
$200K
UFLO1, INC.
San Diego, CA · Founded 2024

UFLO1, INC. provides an AI-powered learning platform called Uflo that offers tools and services for students, teachers, and institutions to build personalized courses, share content, assess knowledge, and analyze data to tailor instruction.

B2B
$200K
Aisona Care Inc.
Los Angeles, CA · Founded 2026

Aisona Care Inc. offers Sona, an AI-powered care companion for Seniors that shares health signals securely with their care team.

Healthcare
$170K
Site Bionics, Inc.
San Diego, CA · Founded 2023

Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.

B2B
Simba Technologies, Inc. hero photo
Seed$170K
Simba Technologies, Inc.
Los Angeles, CA · Founded 2022

Simba Technologies offers an AI-enabled field data platform that helps nonprofits, funders, and social enterprises collect field data using WhatsApp surveys.

SeedB2B
Solace Technologies Corp hero photo
$154K
Solace Technologies Corp
Marina Del Rey, CA · Founded 2024

Solace is the real-time data platform for the enterprise — one platform that connects every application, cloud, partner, and edge, turns raw events into real-time context, and powers agentic AI in production.

B2B
$125K
Wallabi, Inc.
San Diego, CA · Founded 2023

Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

B2B
Bristlecone Holdings, Inc. hero photo
Seed$120K
Bristlecone Holdings, Inc.
Carlsbad, CA · Founded 2026

Bristlecone is the leading provider of connected logistics solutions, including AI applications, SAP integration, and more.

SeedB2B
$100K
MyVillage, Inc.
Culver City, CA · Founded 2024

MyVillage, Inc. leverages culture and technology to convert community wisdom into knowledge repositories for students by collecting advice, stories, and history of local communities and families, using AI and LLMs to create knowledge repositories, and developing opportunities for families and communities to share their knowledge.

B2B
ARTIFICIAL GENIUS INC. hero photo
Seed$100K
ARTIFICIAL GENIUS INC.
Venice, CA · Founded 2023

Explore Artificial Genius for cutting-edge AI solutions that redefine engineering and enhance enterprise productivity.

SeedB2B
Cytodyme, Inc. hero photo
Seed$75K
Cytodyme, Inc.
San Diego, CA · Founded 2024

AI-Enabled Quality and Regulatory Workflows

SeedB2B
Guesty, Inc. hero photo
$70K
Guesty, Inc.
Covina, CA · ~11-50 employees

Guesty is the AI-powered vacation rental software for short-term rental operators, from solo hosts to large portfolios.

B2B
Vincit California, Inc. hero photo
$53K
Vincit California, Inc.
Irvine, CA

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

B2B
DoneCast, Inc. hero photo
$45K
DoneCast, Inc.
Glendale, CA · Founded 2026

Record, edit with voice commands, and publish your podcast in minutes. DoneCast's AI handles filler removal, mistake correction, and professional mastering automatically.

B2B
Loan Atlas Inc. hero photo
$45K
Loan Atlas Inc.
Thousand Oaks, CA · Founded 2023

The Loan Atlas installs five AI-powered systems into your mortgage business so you close more loans in less time, with less chaos.

B2B
Soar Technologies Inc. hero photo
$40K
Soar Technologies Inc.
Covina, CA · Founded 2024

SoarTech develops intelligent software that reasons like humans to automate complex tasks, simplify human-machine interactions, and model human behaviors, focusing on human-centered and cognitive AI solutions for DoD research and development.

B2B
$25K
Operait Health Inc.
Glendale, CA · Founded 2022

Operait Health Inc. provides an end-to-end AI agent that aims to elevate patient experience, reduce operational costs, and improve outcomes for hospitals, health plans, and providers.

B2B
Elf Labs, Inc hero photo
$25K
Elf Labs, Inc
Los Angeles, CA

Elf Labs aims to disrupt the IP market by leveraging advanced AI, patented technology, and profitable character IP, having secured landmark rights to characters like Cinderella and Snow White.

B2B
TurboPermit Corp hero photo
$20K
TurboPermit Corp
Santa Monica, CA · Founded 2024

TurboPermit helps residential builders and developers cut permit approval time by up to 50% with AI plan pre-check, digital forms, and one source of truth. Book a demo.

B2B
Scientia Capital Solutions, Inc. hero photo
$20K
Scientia Capital Solutions, Inc.
Irvine, CA · Founded 2025

Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.

B2B
$15K
Ai DataFrames, Inc.
Newport Beach, CA · Founded 2024

Ai DataFrames develops AI-driven prediction models that analyze global financial data and provide predictive intelligence for the top 16 Futures markets, aiming to predict days of high market imbalance.

B2B
$9K
iNSIGHT INTEGRITY GROUP, INC.
El Segundo, CA · Founded 2025

Integrity is a company that uses AI-powered technology, data, and human touch to deliver insurance, financial, and investment advisory services.

B2B
Influsence, Inc. hero photo
$5K
Influsence, Inc.
San Diego, CA · Founded 2023

Influsence, Inc. provides an AI SaaS platform that offers data insights for influencer marketing to help increase reach, engagement, and revenue for ad agencies and companies.

B2B
Backplain, Inc. hero photo
$725
Backplain, Inc.
Carlsbad, CA · Founded 2023

Multi-model AI with a patent-pending AI Firewall — for teams where data privacy is not optional. 47 models, one workspace, sensitive data stays home.

B2B
Clarity Management Aggregator, LLC hero photo
$44
Clarity Management Aggregator, LLC
Los Angeles, CA · Founded 2025

Clarity AI is an AI-native platform for extra-financial intelligence that supports financial institutions, companies, governments, and consumers in making decisions.

Industrials
Staxiom hero photo
Seed
Staxiom
Brea, CA

Staxiom provides diligence-grade accounting for startups — bookkeeping, tax prep, and capital strategy, with an AI-assisted R&D tax credit engine reviewed by EY-trained CPAs. Founded by the team behind Ardius, the R&D tax credit company Gusto acquired in 2021.

SeedFintech
Bootstrapped
KanDo
Irvine, CA · 2 employees

KanDo is an AI-powered knowledge and process management tool for creating and managing AI-assisted Standard Operating Procedures, with enterprise-grade multi-tenant authentication and an intelligent knowledge base.

BootstrappedEnterprise Software
Bootstrapped
JouraBooks
Irvine, CA · 1 employees

JouraBooks is desktop-native accounting software for teams migrating off QuickBooks Desktop, offering a practical QBD import path, local-first data control on your own machine, and an AI assistant (Ask Joura) for accounting and back-office work. Currently in private beta.

BootstrappedSoftware as a service (SaaS)
Bootstrapped
NavOps
Los Angeles, CA · ~1-10 employees

NavOps connects the software your business already uses and uses AI to automate repetitive work across those systems.

BootstrappedArtificial Intelligence (AI)
PARES AI hero photo
PARES AI
Los Angeles, CA · Founded 2025 · 3 employees

AI-native real estate services firm

Y CombinatorReal Estate and Construction
Applied Data Finance hero photo
Applied Data Finance
San Diego, CA

Applied Data Finance is a fintech innovator that offers fair and responsible credit access to underestimated U.S. consumers through an AI-powered underwriting and lending platform.

Fintech
Condor Software hero photo
Condor Software
San Diego, CA

Condor is an AI-powered platform that unifies clinical, operational, and financial data into a single source of truth for life sciences companies to manage R&D finances.

B2B
MixerBox hero photo
MixerBox
Los Angeles, CA · Founded 2013 · 30 employees

AI Super-Apps to Live Easier | The anything anytime superapps…

Y CombinatorConsumer
Compose.ai
Carlsbad, CA · Founded 2021 · 7 employees

Cut your writing time by 40% with AI-powered autocomplete

Y CombinatorB2B
Boumarang Inc. hero photo
Boumarang Inc.
Irvine, CA · Founded 2024

Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.

B2B
HONK hero photo
HONK
Los Angeles, CA

HONK provides an AI-powered platform for roadside assistance, specialized vehicle services, accident management, vehicle logistics, and catastrophe event management.

B2B
The Adversarial Company hero photo
The Adversarial Company
North Hollywood, CA

The Adversarial Company builds AI-native denial and deception systems, including WRAITH, AI software for generating and evaluating camouflage for machine-observed environments.

Defense Technology
Mirai hero photo
Mirai
Hermosa Beach, CA

Mirai Labs provides models, runtime, and infrastructure to make on-device AI interactive, ambient, and continuous, specifically co-designing models and runtime for Apple Silicon.

B2B
FilmAI.tech, Inc. hero photo
FilmAI.tech, Inc.
Los Angeles, CA · Founded 2024

Using the Power of AI to Enhance Movies We control the digital rights to 5,000 Hollywood motion pictures and we have the option to license more. We are using the latest AI technology to enhance our film library as well as the films of other filmmakers. As veteran filmmakers, our mission is to use AI ... Read more

B2B
Eagle Mountain Data Inc hero photo
Eagle Mountain Data Inc
Irvine, CA · Founded 2025 · ~11-50 employees

Eagle Mountain Data provides next-generation infrastructure, including GPU services, storage, and networking, designed for complex AI workloads and real-time responsiveness at the edge.

B2B
Korso
Irvine, CA · Founded 2026 · 3 employees

The AI-native agency

Y CombinatorB2B
Epsilon3 hero photo
Epsilon3
Los Angeles, CA · Founded 2021 · 12 employees

AI-Powered ERP, MES, and Test Software for Complex Operations

Y CombinatorB2B
Pirros hero photo
Pirros
Los Angeles, CA · Founded 2022 · 44 employees

AI Platform for Architects and Engineers

Y CombinatorB2B
Atmeto hero photo
Atmeto
Los Angeles, CA · Founded 2023 · 2 employees

We develop ML that optimizes how batteries in the grid store energy

Y CombinatorIndustrials
Superunit
Los Angeles, CA · Founded 2024 · 5 employees

Faster, more profitable background checks with AI

Y CombinatorB2B
Relaw hero photo
Relaw
Los Angeles, CA · Founded 2025 · 2 employees

AI Legal OS

Y CombinatorB2B
rct AI
Los Angeles, CA · Founded 2018 · 40 employees

build AI NPCs

Y CombinatorConsumer
Oda hero photo
Oda
Los Angeles, CA · Founded 2020 · 9 employees

AI Agent for Home Design

Y CombinatorB2B
Elythea hero photo
Elythea
San Diego, CA · Founded 2023 · 2 employees

ML to predict and prevent pregnancy complications

Y CombinatorHealthcare
Grocalo hero photo
Grocalo
Los Angeles, CA · Founded 2026 · 0 employees

AI brain that runs content for creators

Y CombinatorConsumer
Legionfarm hero photo
Legionfarm
Los Angeles, CA · Founded 2020 · 7 employees

AI workspace for professional gamers

Y CombinatorConsumer
Juicebox hero photo
Juicebox
Los Angeles, CA · Founded 2022 · 65 employees

AI-powered talent sourcing for recruiters

Y CombinatorB2B