Artificial Intelligence startups in Southern California
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Companies
ArcScore empowers athletes, schools, and brands with AI-driven insights to maximize NIL opportunities and build authentic partnerships.
LungLife AI is a diagnostic company focused on the early detection of lung cancer from a simple blood draw enhanced by artificial intelligence.

Altolabs Inc. provides AI solutions for enterprises, designed for accountability, data residency, and full control over how intelligence is governed and deployed.

SuperMem GrowthOS pairs AI speed with human judgment to provide growth solutions, with real operators closing what AI cannot.
AI phone agents that call, qualify, and route your leads in under a minute. Built-in CRM integrations for insurance, legal, financial, and medical businesses.

EFAS Technologies revolutionizes water leak detection with its groundbreaking solution, the Global AI Leak Locator (GAILL), which uses AI-Powered Software for Detecting & Localizing Anomalies in Water Systems.
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Simon AI is an agentic marketing platform with an AI-first CDP that helps marketers create personalized campaigns grounded in live customer data and real-world signals.
DeepCast, Inc. provides an AI SaaS platform that helps engineers and scientists build practical models, integrate diverse data sources and tools, and create digital twins for product development.

UFLO1, INC. provides an AI-powered learning platform called Uflo that offers tools and services for students, teachers, and institutions to build personalized courses, share content, assess knowledge, and analyze data to tailor instruction.
Aisona Care Inc. offers Sona, an AI-powered care companion for Seniors that shares health signals securely with their care team.
Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.

Simba Technologies offers an AI-enabled field data platform that helps nonprofits, funders, and social enterprises collect field data using WhatsApp surveys.

Solace is the real-time data platform for the enterprise — one platform that connects every application, cloud, partner, and edge, turns raw events into real-time context, and powers agentic AI in production.
Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

Bristlecone is the leading provider of connected logistics solutions, including AI applications, SAP integration, and more.
MyVillage, Inc. leverages culture and technology to convert community wisdom into knowledge repositories for students by collecting advice, stories, and history of local communities and families, using AI and LLMs to create knowledge repositories, and developing opportunities for families and communities to share their knowledge.
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Guesty is the AI-powered vacation rental software for short-term rental operators, from solo hosts to large portfolios.

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

Record, edit with voice commands, and publish your podcast in minutes. DoneCast's AI handles filler removal, mistake correction, and professional mastering automatically.

The Loan Atlas installs five AI-powered systems into your mortgage business so you close more loans in less time, with less chaos.

SoarTech develops intelligent software that reasons like humans to automate complex tasks, simplify human-machine interactions, and model human behaviors, focusing on human-centered and cognitive AI solutions for DoD research and development.
Operait Health Inc. provides an end-to-end AI agent that aims to elevate patient experience, reduce operational costs, and improve outcomes for hospitals, health plans, and providers.

Elf Labs aims to disrupt the IP market by leveraging advanced AI, patented technology, and profitable character IP, having secured landmark rights to characters like Cinderella and Snow White.

TurboPermit helps residential builders and developers cut permit approval time by up to 50% with AI plan pre-check, digital forms, and one source of truth. Book a demo.

Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.
Ai DataFrames develops AI-driven prediction models that analyze global financial data and provide predictive intelligence for the top 16 Futures markets, aiming to predict days of high market imbalance.
Integrity is a company that uses AI-powered technology, data, and human touch to deliver insurance, financial, and investment advisory services.

Influsence, Inc. provides an AI SaaS platform that offers data insights for influencer marketing to help increase reach, engagement, and revenue for ad agencies and companies.

Multi-model AI with a patent-pending AI Firewall — for teams where data privacy is not optional. 47 models, one workspace, sensitive data stays home.

Clarity AI is an AI-native platform for extra-financial intelligence that supports financial institutions, companies, governments, and consumers in making decisions.

Staxiom provides diligence-grade accounting for startups — bookkeeping, tax prep, and capital strategy, with an AI-assisted R&D tax credit engine reviewed by EY-trained CPAs. Founded by the team behind Ardius, the R&D tax credit company Gusto acquired in 2021.
KanDo is an AI-powered knowledge and process management tool for creating and managing AI-assisted Standard Operating Procedures, with enterprise-grade multi-tenant authentication and an intelligent knowledge base.
JouraBooks is desktop-native accounting software for teams migrating off QuickBooks Desktop, offering a practical QBD import path, local-first data control on your own machine, and an AI assistant (Ask Joura) for accounting and back-office work. Currently in private beta.
NavOps connects the software your business already uses and uses AI to automate repetitive work across those systems.

AI-native real estate services firm

Applied Data Finance is a fintech innovator that offers fair and responsible credit access to underestimated U.S. consumers through an AI-powered underwriting and lending platform.

Condor is an AI-powered platform that unifies clinical, operational, and financial data into a single source of truth for life sciences companies to manage R&D finances.

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Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.

HONK provides an AI-powered platform for roadside assistance, specialized vehicle services, accident management, vehicle logistics, and catastrophe event management.
The Adversarial Company builds AI-native denial and deception systems, including WRAITH, AI software for generating and evaluating camouflage for machine-observed environments.

Mirai Labs provides models, runtime, and infrastructure to make on-device AI interactive, ambient, and continuous, specifically co-designing models and runtime for Apple Silicon.

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Eagle Mountain Data provides next-generation infrastructure, including GPU services, storage, and networking, designed for complex AI workloads and real-time responsiveness at the edge.

The AI-native agency


AI-Powered ERP, MES, and Test Software for Complex Operations


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We develop ML that optimizes how batteries in the grid store energy

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AI Legal OS

build AI NPCs


AI Agent for Home Design
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ML to predict and prevent pregnancy complications


AI brain that runs content for creators


AI workspace for professional gamers


AI-powered talent sourcing for recruiters