Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Poseida Therapeutics, a San Diego cell and gene therapy company founded by Eric Ostertag and once listed on Nasdaq as PSTX, was acquired by Roche in a December 2024 tender offer at $9.00/share cash plus a contingent value right.
Series D$25.0MPersonalized, two-way SMS, WhatsApp, Apple Messages, RCS, and more. No algorithms. No noise. Just your Community.
$24.9MAvaamme mahdollisuudet ja takaamme sinulle paremman kasvun: Arvo Partners, täyden palvelun digitaalinen markkinointitoimisto ja tuleva strateginen kumppanisi.
Series C$24.5MAI-powered risk adjustment software designed to increase the profitability of Medicare risk contracts.
Muse Organic (maker of MyMuse hydration drinks) was co-founded by Linda Collins, who also co-founded the bottled water brand ZENWTR.
A SHOC Energy was founded in 2019 by Lance Collins, who previously founded the beverage brands Fuze, NOS Energy, and Core.
$24.0MOur all-in-one software is built for home and commercial contractors to keep all their service visits and construction projects running smoothly.
Series B$24.0MKinderFarms was co-founded in 2018 by actress Jessica Biel, along with Jeremy Adams and Greg Willsey.