Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
EXPLORE BY CITY
WHAT SOUTHERN CALIFORNIA BUILDS
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Founded in 2018 by Ahmad Malkawi, a wireless-industry veteran with prior stints at AT&T, Qualcomm, and Sprint; the Irvine-based company builds telecom hardware, software, and AI solutions for IoT connectivity.
Series B$4.3MHomeState is a Texas kitchen in Southern California serving breakfast tacos, queso, brisket, house-made flour tortillas and genuine hospitality.
Seed$4.2MPlay Eggscape, the ultimate multiplayer Mixed Reality game where you battle robots, collect abilities, and create custom levels with up to 4 players. Join the immersive fun now!
Series A$4.2MAI-driven medical coding from Synaptec Health - a more accurate, secure, and comprehensive solution for all your medical coding needs.
Series A$4.2MTenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.
Founded in 2018 by Dr. Virender K. Sharma, a serial medtech entrepreneur and former Mayo Clinic professor, alongside CEO Dr. Holger Friedrich; the company develops single-shot catheter ablation technology for atrial fibrillation.
Seed$4.1MAcurion's OncoGaze™ technology delivers critical genomic insights at the biopsy stage, empowering oncologists to make precision therapy a reality for more patients.
Seed$4.1MLaunchPoint Electric Propulsion Solutions is a propulsion and power generation company supplying lightweight, highly efficient, power-dense, electric and hybrid systems for aerospace, defense, unmanned aircraft systems, and advanced air mobility.