Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Seed$270KDo Less, Win More With AI-Driven Sales Coaching
Seed$260KFounded by Koehl Robinson, who started CeliaRx's peptide telehealth service after peptides helped her overcome her own health challenges; profiled by Forbes in June 2026.
Seed$260KWe believe that everyone - including those with sensitivities and allergies - should be able to enjoy fragrance. Our non-toxic fragrances are formulated to be free of all 82 EU fragrance allergens and top 9 food allergens, on top of being free from hormone disruptors and carcinogens.
Seed$251K
Seed$250KDiscover Trethera’s breakthrough therapy TRE-515 for autoimmune, oncology, and neuroinflammatory diseases. Learn about our science-driven innovation.
Seed$250KStruggling with your mental health? Our online counsellors meet with you through our video counselling platform, when and where it works best for you.
Seed$250KDeepcast, an AI-powered podcast platform led by CEO/co-founder Lucas Dickey and based in Los Angeles, has received investment from Automattic (WordPress's parent company) and Idealab.
Seed$250KLyve Studios, founded in 2025 and headquartered in Los Angeles by founder Laurent Gattereau, is an official TikTok Shop Partner offering live-commerce production.