Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Series B$22.0MMedical billing and revenue cycle management where AI agents carry every claim and expert billers fight the hard dollars. Free scan of your last 90 days.
Series A$21.9MInnova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.
Series D$21.8MThe key to managing cancer is early detection. ClearNote Health makes this possible by finding signals of cancer in the blood early
German skincare giant Beiersdorf (maker of Nivea) became an investor in the company; Amicrobe later rebranded as Macro Biologics.
Series A$21.4MCaramel is the safe & easy way to complete any private used car sale. Compatible with any car for sale by owner, Caramel does the DMV work & more for free.
$21.3MLumati is a global holistic wellness optimization platform redefining longevity through science, technology, and personalized care — supporting cellular health, promoting recovery, and sustaining vitality.