Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
$13.1MGenius Brands International is dedicated to creating and licensing animated multimedia that delivers "Content with a Purpose" for ages toddlers to tweens.
Series C$13.1M
Seed$13.0MValora Therapeutics is developing AbLec™ multispecific antibodies and T-Lec™ T cell engagers — antibody-engineering platforms that decoy the glyco-immune checkpoint to create best-in-class therapeutics for cancer and autoimmune disease.
Seed$13.0MCo-founded by Max Spielberg, son of director Steven Spielberg, along with former EA producer Tatyana Dyshlova; the game studio raised $3.5 million in seed funding.
Series D$12.9MEverest Properties is a privately-held real estate investment firm specializing in acquisition, recapitalization, and asset management of real estate.
$12.7MFounder and CEO Gerald Proehl previously led Santarus Inc. through its $2.6 billion sale to Salix Pharmaceuticals.
Series A$12.5MIts 2026 $14M Series A (led by Blueprint Equity) included angel investors Paul Black (former Allscripts CEO) and Chris Sullens (CentralReach CEO).
Series A$12.5MHeadgum is a comedy podcast network co-founded in 2015 by Jake Hurwitz and Amir Blumenfeld (of CollegeHumor's Jake and Amir) along with Marty Michael; its shows include the official jackass podcast hosted by Johnny Knoxville.