Southern California's
Startup Directory
Series B$84.3MRebuilding healthcare with AI at the core
Pre-Seed$250KBetter, faster tech vendor research
Series D$833.1MWe provide efficient in-space mobility that moves payloads from low Earth orbit to any destination. Our vehicles deliver rapid, reliable access, reducing costs and timelines to make space operations feasible for commercial, government, and scientific missions.
Series C$80.1MOutpace AI-driven attacks. Unify Digital Risk Protection, Human Risk Management, and Email Security to stop digital threats before they scale, empower your teams to lead your defense, and scale your SOC with agentic AI.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Seed$930KSeqOnce was co-founded in 2014 by Chris Angermayer and Joseph Dunham as a spinout from the University of Southern California, and has drawn investment from Wavemaker 360 Health and Mount Wilson Ventures.
Seed$850KAt Datum Technologies Group, we are industry veterans with expertise in managed services, technology project delivery, and global workforce solutions.
NFTco was founded by serial entrepreneur Niel Robertson (previously of Trada and Newmerix), based in West Hollywood; the company later rebranded as 'Based,' an NFT trading platform, with Adam Lurie as CEO.
BioSig Technologies (Nasdaq: BSGM), originally a medical-device company, pivoted into real-world-asset tokenization through a 2025 merger with Streamex Exchange, backed by mining financier Frank Giustra as a strategic advisor.
Seed$817KSpotlightNews is the news app built for Gen Z. Access 400+ trusted publishers—paywall-free, ad-light, and gamified to spark lifelong news habits.
Seed$800K
Seed$800KShop organic & gluten-free pasta made in Italy with clean, simple ingredients. Bronze-die & slow-dried for authentic texture. Curated by Giada De Laurentiis.