Southern California's
Tech
Startup Directory
Showcasing Southern California's innovation, one startup at a time. Every funded and bootstrapped company, from seed round to first dollar of revenue, tracked as it happens.
Includes SEC Form D filings from the last 3 years, plus all-time totals for companies sourced from YC and news coverage.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Series B$96.9MPatientFi was co-founded in 2017 by Todd Watts and Scott Jorgensen and received a growth equity investment from Questa Capital in 2024.
Series B$94.4MAdvanced material solutions—from AI-driven design to agile U.S. manufacturing—for defense, aerospace, & high-performance applications
Series B$90.0MVertimass, an Irvine-based renewable fuels company, is chaired by real estate investor Bill Shopoff and led by CEO Dr. Charles Wyman.
TRC 2004 was co-founded by Third Rock Ventures and Two River, the same investor group behind Kite Pharma (sold to Gilead for roughly $11.9B), and later emerged publicly as Candid Therapeutics with a $370M capital raise.
Series B$85.0MAardvark Therapeutics is a clinical-stage biopharmaceutical company developing novel, small-molecule therapies designed to inhibit hunger and treat metabolic
Series B$85.0MProactive health memberships combining Whole Body MRI, advanced blood biomarker testing, and ongoing clinical guidance—designed to help you track your health year over year.
Series B$84.3MRebuilding healthcare with AI at the core
Series B$80.3MFDA-cleared dental AI that detects 37% more disease. Join 29,000+ dental practices using Pearl's dental AI software. Book a demo.