Southern California's
Tech
Startup Directory
Showcasing Southern California's innovation, one startup at a time. Every funded and bootstrapped company, from seed round to first dollar of revenue, tracked as it happens.
Includes SEC Form D filings from the last 3 years, plus all-time totals for companies sourced from YC and news coverage.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
$325.4MIambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.
Series C$300.0MSkyryse is building a universal operating system for flight, SkyOS, to simplify cockpits and standardize aircraft controls, making flight easier and safer.
Series C$271.2MNewlight | AirCarbon - a natural, carbon-negative, regenerative, ocean-degradable material that can replace plastic. Harnessing the technology in nature to improve the world.
Series E$265.1MThe El Segundo aerospace-parts manufacturer, known as Amca, launched with $76.5 million in initial funding from Caffeinated Capital.
Merck agreed to acquire the San Diego biotech for approximately $9.2 billion in November 2025.
Series C$238.0MFounded in 2012 by two UC San Diego PhD alumni, Jared Tangney and Josh Windmiller, originally under the name Electrozyme.
Co-founded by Drew Weissman, the 2023 Nobel Prize winner in Physiology or Medicine for mRNA vaccine research, alongside CAR-T pioneer Carl June; the company was later acquired by AbbVie.