Southern California's
Tech
Startup Directory
Showcasing Southern California's innovation, one startup at a time. Every funded and bootstrapped company, from seed round to first dollar of revenue, tracked as it happens.
Includes SEC Form D filings from the last 3 years, plus all-time totals for companies sourced from YC and news coverage.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Series B$36.0Munlimited AI conversations, translation, and voice recordings — all in your $199 AI-native device rabbit r1, plus a chance to explore cutting-edge agents.
Series B$36.0MFounded in 2023 by Shelby Wild, the clean personal-care brand has raised roughly $40M from investors including Ambarone Ventures and Scoop Ventures.
Series B$35.5MFounded by Jeff Appelbaum (a former BeachMint executive), the Los Angeles restaurant-brand platform appeared on Shark Tank.
Co-founded by Anton Kittelberger and Frank Westermann, who himself lives with diabetes; backers include Define Ventures and 7Wire Ventures.
Series B$32.9MProtego Bio is a clinical-stage biotech developing first-in-class small molecule pharmacological chaperones for AL amyloidosis and other protein misfolding diseases.
Series B$32.0MThe most comprehensive executive health assessment — full-body MRI, whole genome sequencing, 120+ biomarkers & AI analysis in one visit. Starting at $8,000.
Series B$30.3MFounded by Ryne O'Donnell in 2014, who self-funded the company; he briefly sold his majority stake and left in 2017 before returning as chairman.
Co-founded by CEO Nicole Clark in 2017; the legal analytics platform raised a $15 million Series B in 2023.