Southern California's
Tech
Startup Directory
Showcasing Southern California's innovation, one startup at a time. Every funded and bootstrapped company, from seed round to first dollar of revenue, tracked as it happens.
Includes SEC Form D filings from the last 3 years, plus all-time totals for companies sourced from YC and news coverage.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Series F$98.3MNeOnc is a clinical-stage life sciences company developing a novel intranasal drug delivery system and platform technology to treat brain cancers and other central nervous system (CNS) diseases by bypassing the Blood-Brain Barrier (BBB).
Series B$96.9MPatientFi was co-founded in 2017 by Todd Watts and Scott Jorgensen and received a growth equity investment from Questa Capital in 2024.
Series B$94.4MAdvanced material solutions—from AI-driven design to agile U.S. manufacturing—for defense, aerospace, & high-performance applications
Zen Beverage (maker of ZenWTR) was founded by Lance Collins, the serial beverage entrepreneur who previously created BodyArmor and sold Fuze Beverage to Coca-Cola for $250M.
Series B$90.0MVertimass, an Irvine-based renewable fuels company, is chaired by real estate investor Bill Shopoff and led by CEO Dr. Charles Wyman.
Series A$90.0MObservable Space is building advanced optical systems across laser communications ground stations, ground-based optical sensing, and in-space payloads to help satellites and spacecraft see, track, navigate, and communicate more effectively.