Southern California's
Tech
Startup Directory
Showcasing Southern California's innovation, one startup at a time. Every funded and bootstrapped company, from seed round to first dollar of revenue, tracked as it happens.
Includes SEC Form D filings from the last 3 years, plus all-time totals for companies sourced from YC and news coverage.
Artificial Intelligence
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Aerospace & Defense
Home to SpaceX, Northrop Grumman, and a new wave of hypersonics and space-infrastructure startups.
Entertainment & Gaming Tech
Hollywood's production infrastructure, live events, and a growing games and creator-tools scene.
Semiconductor Hardware
Qualcomm and Broadcom anchor a chip-design cluster spanning the region.
Medical Technology
A deep biotech research base and a growing bench of medical device and diagnostics startups.
B2B
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
Industrials
Manufacturing, hardware, and physical-world operations. Overlaps heavily with the region's decades-old aerospace and defense manufacturing base, now extending into robotics and automated production.
Consumer
Products and apps built directly for individual consumers, drawing on Southern California's media and entertainment base.
Healthcare
Health tech, medical devices, and healthcare services, backed by a decades-old biotech research base and a deep bench of clinical and diagnostics startups.
Fintech
Financial technology: payments, banking, investing, and financial infrastructure.
Education
Education technology and learning platforms built across Southern California.
Real Estate & Construction
Property technology, construction tech, and real estate services.
Co-founded by physicists Dr. Massimiliano Di Ventra and Dr. Fabio Traversa alongside serial entrepreneur John Beane, previously a founder of ecoATM; investors include DARPA and Revolution's Rise of the Rest Seed Fund.
Seed$4.4MFounded in 2007 by cardiothoracic surgeon Dr. Edward Boyle and Paul Molloy to develop anti-occlusion surgical drainage devices; the Anaheim-based company's PleuraFlow system was later distributed exclusively in the US by Maquet Medical Systems.
Seed$4.3MCo-founded by Shane Shahrestani, incubated through Caltech's OTTCP startup program; the company closed an oversubscribed $5M Series Seed Prime round in 2024 backed by investors including Freeflow Ventures and DigiTx Partners.
Seed$4.2MPlay Eggscape, the ultimate multiplayer Mixed Reality game where you battle robots, collect abilities, and create custom levels with up to 4 players. Join the immersive fun now!
Founded in 2018 by Dr. Virender K. Sharma, a serial medtech entrepreneur and former Mayo Clinic professor, alongside CEO Dr. Holger Friedrich; the company develops single-shot catheter ablation technology for atrial fibrillation.
Seed$4.1MAcurion's OncoGaze™ technology delivers critical genomic insights at the biopsy stage, empowering oncologists to make precision therapy a reality for more patients.
Seed$4.1MLaunchPoint Electric Propulsion Solutions is a propulsion and power generation company supplying lightweight, highly efficient, power-dense, electric and hybrid systems for aerospace, defense, unmanned aircraft systems, and advanced air mobility.
Seed$4.1MWhy Use the Virchow Medical Crow’s Nest Biopsy Catchment System? To Improve Core Needle Biopsy Collection, Tissue Management, and Access to Targeted Diagnostics.