B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies

Proper Voltage is the digital bridge that seamlessly links power and product, opening up access to more choices and possibilities.
Mesa Residential partners with market-leading property managers to grow for decades as a multigenerational platform with over 50 years of history building exceptional growth companies.

Catalex Network is a private capital-backed partner for elite boutique insurance defense law firms — back office, technology, and growth resources without giving up your culture.

Personalized, two-way SMS, WhatsApp, Apple Messages, RCS, and more. No algorithms. No noise. Just your Community.

Avaamme mahdollisuudet ja takaamme sinulle paremman kasvun: Arvo Partners, täyden palvelun digitaalinen markkinointitoimisto ja tuleva strateginen kumppanisi.
Muse Organic (maker of MyMuse hydration drinks) was co-founded by Linda Collins, who also co-founded the bottled water brand ZENWTR.

Access to Social Security 3-5 days early.

Quintessent is developing optical connectivity solutions to scale computing and Artificial Intelligence (A.I.).
The entity behind Nixon, the watch and accessories brand founded in 1997 by Andy Laats and Chad DiNenna, which is now backed by private equity firm Trilantic Capital Management.

The 1st warehouse-native platform for experimentation, feature flags, and product analytics. Open source and fully transparent. Trusted by 3,000+ companies.
Welcome to VIAVIA! Redefining the fashion experience for a new generation // Enjoy free shipping and returns on all orders // New Designers and products dropping daily
.png&w=3840&q=75)
Uplifting Results Labs, Inc. provides AI 3D motion capture technology for sports performance, sports medicine, and sports media, utilizing smartphone technology for biomechanical analysis.

Medical billing and revenue cycle management where AI agents carry every claim and expert billers fight the hard dollars. Free scan of your last 90 days.
Innova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.
Caramel is the safe & easy way to complete any private used car sale. Compatible with any car for sale by owner, Caramel does the DMV work & more for free.

Kinetic Automation provides solutions for modern vehicle repair, including automated imaging for collision estimates with Kinetic Vision and digital collision repair services in Kinetic Hubs.
Sydnexis focuses on advancing innovation to treat pediatric progressive myopia, which is the leading cause of vision loss in children, by addressing a critical gap in care.
Immortals Inc is a game and hobby store in Northeast Ohio that offers collectible card games, role-playing adventures, miniature battles, and classic board games, along with dedicated play spaces and events.

NIS, a US based CRO, provides cryo-EM services to accelerate drug discovery, with structural biology, nanoparticle characterization, and GMP compliant imaging.

Unlock Engagement, New Fans & Revenue Through Sports Betting
Novo Space, Co. offers a full ecosystem of products to simplify the development process of complex space systems, including tailored subsystems, electronic boards, and FPGA IP Cores.

FinOps governance for platform teams. Prevent cloud waste and budget overruns before every deploy.

JINX, INC. offers premium dog and cat food, toppers, and treats crafted with high-quality proteins, superfoods, and probiotics.

Equatic has developed an electrolytic process for atmospheric carbon dioxide removal that leverages the size and scale of the oceans, stabilizing carbon dioxide and producing hydrogen as a co-product.

Passes allows creators to monetize their content and build direct relationships with their audience through subscriptions, messaging, and exclusive content.
Sift is the unified observability platform for mission-critical hardware—ingest, store, and analyze telemetry at scale across aerospace, defense, and robotics.
Unlock quantum power with BlueQubit's quantum computing software! Seamlessly access and utilize quantum computers for groundbreaking advancements.

The integrated platform for the electromagnetic spectrum. One platform for RF design, production, and network operations.
Fictions is a game developer and publisher established in 2025. Current titles include LEGO Party and Beast of Reincarnation.

Nuon Inc. provides continuous delivery solutions that enable software vendors to deploy applications into their customers' clouds, supporting use cases like data sovereignty and security.
SYSTM Foods is a company focused on strategically acquiring and nurturing a portfolio of cold chain beverage brands that offer better-for-you functional beverages, including organic coffee, plant-based protein, and low/no sugar gut health options.

Gamefam creates immersive gaming experiences for brands on Roblox and Fortnite, engaging Gen Z & Alpha audiences through innovative campaigns and full-scale amplification programs.

Accrual transforms accounting firms with AI. Automate tax returns, streamline client data collection, and scale your practice with intelligent workflows.
Mixed-Signal Devices Inc. delivers multi-gigahertz digital timing solutions with ultra-low jitter, stability, and programmability for AI infrastructure, 5G networks, and high-performance automotive platforms.

TadHealth is the leading school-based EHR platform designed for K‑12 schools, empowering mental health professionals with intuitive tools to manage care, streamline operations, and improve student outcomes.

EggCo, Inc., operating as Sunnyside Egg Co., produces eggs from hens raised outdoors in mobile coops on fresh pastures, supplemented with certified organic feed without corn, soy, or flax, using regenerative practices.

An integrated communications platform using cloud-hosted phone, chat, contact center and analytics to meet the challenges of today’s business.
Radical Group Inc. helps businesses unlock their full potential through integrated solutions in Data, AI, Digital Design, and Training.

huupe brings you the world’s first smart basketball hoop, providing NBA level workouts, on-demand training, live coaching, data tracking and more.

PM Technologies Corp provides generator sales, installation, service, and maintenance for residential, commercial, and industrial customers, focusing on emergency power solutions.

Welcome to The Foursquare Church. Discover how Foursquare supports local churches and raises up future leaders.

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.
This Carlsbad, CA private-equity vehicle for engineered stone manufacturing is run by managing member Oren Klaff, the investor and author best known for the bestselling sales book "Pitch Anything."
Operating as Harrison-Ross Mortuary in LA, this family-owned funeral home has served the community since 1948 and is now led by its third-generation leader, Chip Smith.
Physical AI infrastructure from code to real world. Abstract with Digital Twins, plug in AI, and ship to production.

Multi-touch attribution and media mix modeling for profitable growth, powered by industry-leading machine learning models. Discover how Northbeam can transform your marketing.

Unprecedented onchain exposure to the world's leading institutional grade private credit managers, including Ares, Apollo, and more.
Modyfi delivers integrative psychiatric care via telehealth — whole-person, insurance-based treatment connecting mind, body, and lifestyle.

Soapbox provides a platform that centralizes, simplifies, and orchestrates order management, inventory management, and shipping management across the entire supply chain.

Science-backed fertility, prenatal, postpartum, perimenopause, and women's health supplements. Trusted by 20,000+ practitioners and experts. Shop Needed.
JS-WR JV, Inc. does business as Willie's Remedy+, the CBD/THC beverage and wellness product line created by musician Willie Nelson.
Arrow turns the heavy equipment industry