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SANTA BARBARA

B2B

27 b2b startups based in Santa Barbara, $164.0M raised total, led by AFFINITY BIOSENSORS LLC ($48.5M raised). See what B2B means more broadly on the B2B industry page.

27
companies
$164.0M
total raised

The breakdown

27 of 27 companies have disclosed funding, $164.0M combined, 11 at Seed stage, making up 68% of the 40 Santa Barbara startups on file across every industry, founding dates span 2018-2025.

Companies

AFFINITY BIOSENSORS LLC hero photo
Series A$48.5M
AFFINITY BIOSENSORS LLC
Santa Barbara, CA

Affinity Biosensors’ LifeScale platform delivers rapid, high-throughput phenotypic antimicrobial susceptibility testing in under four hours, empowering clinical labs to make timely antibiotic decisions and combat drug-resistant infections.

Series AB2B
$25.0M
Mesa Residential Co LLC
Santa Barbara, CA · Founded 2025

Mesa Residential partners with market-leading property managers to grow for decades as a multigenerational platform with over 50 years of history building exceptional growth companies.

B2B
$13.2M
Painted Cave, Inc.
Santa Barbara, CA · Founded 2021

Butterflies are free to fly

B2B
Cognixion Corp hero photo
Seed$8.9M
Cognixion Corp
Santa Barbara, CA · Founded 2021

Cognixion develops accessible, non-invasive brain-computer interfaces combining neuroscience, AI, and spatial computing.

SeedB2B
H2 Clipper, Inc. hero photo
Series A$7.6M
H2 Clipper, Inc.
Santa Barbara, CA · Founded 2022

The infrastructure for the distribution of liquid hydrogen.

Series AB2B
Series A$7.5M
DIMER INSTRUMENTS, INC.
Santa Barbara, CA · Founded 2023

Dimer Instruments creates instruments that enable real-time molecular analysis at multiple points during the pharmaceutical development process.

Series AB2B
Series A$7.3M
bioProtonics, Inc.
Santa Barbara, CA · Founded 2018

BioProtonics is a pioneering company focused on advancing diagnostic imaging through its Magnetic Resonance Histopathology (MRH) technology. MRH offers a non-invasive, high-resolution method for analyzing tissue microarchitecture during routine MRI scans. MRH

Series AB2B
Live Data Technologies, Inc. hero photo
Series A$7.1M
Live Data Technologies, Inc.
Santa Barbara, CA · Founded 2019

Live Data Technologies provides live human capital data, including job-change data on professionals, re-verified and compliantly sourced from the open web.

Series AB2B
Learning Explorer, Inc. hero photo
$6.7M
Learning Explorer, Inc.
Santa Barbara, CA · Founded 2021

Learning Explorer, Inc. offers solutions that personalize learning at scale by combining adaptation, automation, actionable assessment, and engagement to help students achieve their growth goals.

B2B
Seed$6.2M
Musubi Inc.
Santa Barbara, CA · Founded 2023 · ~11-50 employees

We are wholesalers in Japan who import / export Japanese-made products such as everyday items, cosmetics, snacks and food at wholesale prices.We also offer proxy marketing for Japanese companies as well as wholesalers.

SeedB2B
Cliq Products Inc. hero photo
Seed$5.6M
Cliq Products Inc.
Santa Barbara, CA · Founded 2020

CLIQ makes the world’s most portable chairs—ultra-compact, quick to set up, and built for everyday adventure. Whether you’re camping, tailgating, or relaxing at the beach, CLIQ chairs offer comfort, durability, and convenience in a sleek, travel-ready design.

SeedB2B
Shoonya Digital, Inc. hero photo
Seed$3.0M
Shoonya Digital, Inc.
Santa Barbara, CA · Founded 2019

Language learning for kids is easy with Shoonya. Designed to be the best language software for kids, we have many languages to choose from.

SeedB2B
$2.8M
SBMAR25, LLC
Santa Barbara, CA · Founded 2025
B2B
Blue-OCN-Capital, Holdings, LLC hero photo
$2.7M
Blue-OCN-Capital, Holdings, LLC
Santa Barbara, CA · Founded 2022

BESPOKE SOLUTIONS FOR A DYNAMIC M&A ENVIRONMENT.

B2B
Seed$2.1M
Veles
Santa Barbara, CA · Founded 2024 · 5 employees

CPQ for humans and agents

Y CombinatorSeedB2B
$2.0M
Adaya AI, Inc.
Santa Barbara, CA · Founded 2022

Adaya invents AI products and builds every layer of them end to end, including the model, the agent, and the design.

B2B
9ZERO INC. hero photo
Seed$1.8M
9ZERO INC.
Santa Barbara, CA · Founded 2023

Join 9Zero, a climate innovation hub for founders, investors, scientists, and innovators. Explore memberships, events, and workspace in SF and Seattle.

SeedB2B
Shelter DP, LLC hero photo
Seed$1.4M
Shelter DP, LLC
Santa Barbara, CA · Founded 2025

Shelter Products Inc. specializes in delivering high-quality building materials for large-scale construction projects nationwide. Discover how we can help you.

SeedB2B
$1.3M
KR Investment Partners Select LLC
Santa Barbara, CA · Founded 2024
B2B
Benefact(or), Inc. hero photo
Seed$1.3M
Benefact(or), Inc.
Santa Barbara, CA · Founded 2021

BeneFactor Funding Corp provides financing to businesses by purchasing their invoices, offering fast and flexible funding, and managing accounts receivable and credit departments.

SeedB2B
Seed$650K
Storygize Inc.
Santa Barbara, CA

Storygize Inc. appears to be involved in the native advertising industry, providing insights and information related to native ad technology and strategies through its blog.

SeedB2B
Expond Inc. hero photo
Seed$500K
Expond Inc.
Santa Barbara, CA · Founded 2021

Explore private in-person and group experiences: Yoga, personal training, kayaking, hiking, surfing, meditation and so much more in Santa Barbara, California!

SeedB2B
Seed$450K
Remaker Labs, Inc.
Santa Barbara, CA

Remaker Labs, co-founded by Sky Gilbar and David Silverander in Santa Barbara, raised $1.2M from over 15,000 Kickstarter backers in 70 countries for its 'Hitch' cup-and-bottle product, according to Forbes.

SeedB2B
SkillBench, Inc. hero photo
$430K
SkillBench, Inc.
Santa Barbara, CA · Founded 2024

AI-enabled productivity and skill optimization for firms using Generative AI

B2B
$50K
Reel Fit, Inc.
Santa Barbara, CA · Founded 2024
B2B
$30K
Calculated Development LLC
Santa Barbara, CA · Founded 2020

Calculated Development LLC was formed to turn author Nova McBee's bestselling "Calculated" novel series into a film franchise, now in development with One Door Studios and Apelles Entertainment.

B2B
$5K
Skin Safeguard Inc
Santa Barbara, CA · Founded 2024
B2B