B2B
Business software and services sold to other companies, built in San Diego.
The breakdown
106 of 110 companies have disclosed funding, $2.48B combined, 28 at Seed stage, making up 28% of the 400 San Diego startups on file across every industry, founding dates span 2017-2026.
Companies

Shield AI is a defense-tech company building the world's best AI pilots and next-generation aircraft.

Firestorm Labs - Democratize the fight with radically-affordable, mission-adaptable power for air, land, and sea.
Electrochemical Additive Manufacturing Mass Production of Next Generation Components High-Resolution Metal 3D Printing at Scale Electrochemical Additive Manufacturing (ECAM) is... Read More

Gallant offers ready-to-use stem cell therapies that help pets heal from within, restoring vitality and supporting longer, healthier lives.

Brain Corp is an autonomous technology company powering the most proven robots and AI, helping organizations create more productive and intelligent operations.

Sol-ti sells organic living beverages, including SuperShot, SuperAde, and SuperStix products, which are glass bottled, cold pressed, and made in the USA.

Price with precision. Negotiate with confidence. Turquoise is the platform 300+ healthcare organizations use to make sense of rates, contracts, and compliance.
Operates as Seasats; CEO and co-founder Mike Flanigan launched the San Diego autonomous-vessel maker in 2020, and it closed a $20 million Series A backed by Philip Bilden.
The Encinitas-based clinical-stage biotech was acquired by Eli Lilly for $1.2 billion in cash, after IPOing on Nasdaq (VTYX) in 2021.

Avaamme mahdollisuudet ja takaamme sinulle paremman kasvun: Arvo Partners, täyden palvelun digitaalinen markkinointitoimisto ja tuleva strateginen kumppanisi.

NIS, a US based CRO, provides cryo-EM services to accelerate drug discovery, with structural biology, nanoparticle characterization, and GMP compliant imaging.

FinOps governance for platform teams. Prevent cloud waste and budget overruns before every deploy.

An integrated communications platform using cloud-hosted phone, chat, contact center and analytics to meet the challenges of today’s business.
JS-WR JV, Inc. does business as Willie's Remedy+, the CBD/THC beverage and wellness product line created by musician Willie Nelson.

BlueNalu, Inc. develops cell-cultivated seafood, beginning with bluefin tuna toro—crafted with care and produced without fishing.
Provisio Medical Technologies Corp. is dedicated to developing innovative solutions for Peripheral Artery Disease, including an automated, integrated smart-catheter technology called the SLT Platform which includes the SLT FLOW, the world's first and only catheter-based volumetric blood flow measurement intra-procedurally.
HypeVR built cinematic volumetric VR capture technology using a 14-camera 6K rig, founded in San Diego in 2015.
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A piezoacoustic platform technology that makes the world’s batteries last longer, charge faster, and be safer.
Get instant real-time visibility with EdgeX. Wire-free RTLS, asset tracking, and environmental monitoring. Fast ROI, no IT burden, deployed in hours.

Vimcal is the world’s fastest calendar, beautifully designed for people who have too many meetings. Drag to share availabilities, schedule across time zones, and see all your Outlook and Google calendars in one view.
Search engines and social networks are not designed for due diligence. Ferret’s unparalleled AI platform combined with world class information provides you with exclusive relationship intelligence that can help you avoid high-risk individuals and spot promising opportunities.

Technology purpose-built for libraries, archives, and museums for improving Access, Searching, Resource Sharing (interlibrary loan) & Digital Preservation.

Measurabl offers comprehensive ESG solutions, empowering businesses with data-driven insights for sustainability & compliance. Learn More

Serenity is a unified EHS platform built on ServiceNow for incident management, audits, risk assessments, compliance, and cyber risk — with AI-powered safety insights.
BURL Concepts provides innovative ultrasound solutions to instantly access brain performance and guide clinical interventions.
Also known as FuturHealth, this San Diego weight-loss company was co-founded and is led by CEO Luke Mahoney.

As leaders in cathode innovation, we develop materials that drive clean energy solutions. Click here to explore our pioneering work in battery technology.
Co-founded by physicists Dr. Massimiliano Di Ventra and Dr. Fabio Traversa alongside serial entrepreneur John Beane, previously a founder of ecoATM; investors include DARPA and Revolution's Rise of the Rest Seed Fund.

SkySafe’s advanced drone detection system and airspace intelligence platform enables organizations to identify, track, analyze, and act on unauthorized drone activity.
Also known as Elevate Dynamics; co-founder Daniel Magy previously founded Citadel Defense Company, a counter-drone defense firm that was later acquired by Blue Halo.

GTR helps home service companies grow with referral software, branded apps, and automated rewards. Turn happy customers into your best lead source.

Aervivo enables our Partners to provide community wide Gigabit managed WiFi, delighting the communities they serve and generating an outstanding 100%+ IRR, quickly.

Crop Diagnostix uses plant RNA to detect asymptomatic crop stress before symptoms appear. Asymptomatic Agronomy for partners, retailers, and input providers.

AMBYTECH is an IT consulting and digital transformation company based in Paris that assists large enterprises and the banking sector with their digital transformation.

Soleic technology is the world's first fully biodegradable, high performance polyurethane material. Plant-based. Zero microplastics.

Self Inspection uses AI trained on 20M+ images to automate vehicle damage detection, condition reports, and CR scoring — built for dealers, fleets, rentals, and lenders.
Founded in 2014 by Patrick Henry, Farooq Anjum, and Jeff Campbell, the agtech soil-sensor company was acquired by Goanna Ag in August 2025.
Growthsayer was founded by Phillip Geltman, a San Diego-based supply chain specialist who originally built the platform to optimize cannabis industry supply chains before expanding into broader retail demand planning.
Hauler Hero is a waste management software solution that helps waste haulers improve their operations, increase efficiency, and reduce costs.

Streamline your functional health business with Biocanic to get better better scale and outcomes for you and your clients.
Roanoke City Public Schools (RCPS) provides educational services and resources for students, families, and the community, including academic programs, special education, and various support departments.
Operating as Assumable.io, it was co-founded by Ryan Carrillo and Louis Ortiz and drew national coverage (including the New York Times) for its marketplace matching buyers with homes carrying low-rate assumable mortgages.

Objective Corporation creates digital government software solutions in areas like information intelligence, planning & building, and regulatory solutions, aimed at helping government shift to being completely digital and driving stronger communities.

Looq.ai builds an AI handheld photogrammetry platform (qCam/qAI/qApp) for 3D land and utility surveying.
TPT Global Tech is a technology holding company with an emphasis on Media Content, Medical Technology and Telecommunications.

Recruitment CRM for full-time, seasonal, and contract talent. Outreach automation keeps relationships warm and makes rediscovery easy. Works with your ATS.
Yatiri Bio, Inc. is re-enisioning the pharmaceutical industry's current drug discovery process by integrating patient data sets with testable empirical models to guide patient selection and clinical development, utilizing advanced proteomics and bioinformatics tools and deep learning models.
Address Insite, Inc. provides site acquisition services by simplifying development in the wireless industry and offers wireless consulting services.
Shreenika Pioneering Inc. creates high-performance, cost-effective chemicals through biotechnology for various industries, aiming to make sustainability an easy economic choice.
For the ones who believe fun comes in all forms, there’s Improv Cocktails.Our full-flavored, premium non-alcoholic cocktails taste like the real deal, but without the booze. They’re ready to enjoy if you’re going dry, and ready to spike if you’re not.
Double Gold Holdings provides fine beverages from around the world, crafted by artisans and maestros, with a mission to be a first-in-class international adult beverage sales & marketing company that builds premium brands responsibly.
Terafiber was founded by Jim Hanley, a San Diego fiber-infrastructure entrepreneur who had previously founded Netly Fiber, another citywide fiber-network builder, before starting Terafiber in 2023.

Mobile fundraising platform for nonprofits with compliant text messaging, Text-to-Give, and donor engagement. Trusted by 1,000+ organizations.

Gensee builds practical control infrastructure for AI operating across real developer and production environments by evaluating AI requests, granting narrowly scoped authority, mediating privileged effects, and recording what actually happened.

SmartProperty's Living Reserve Study gives HOA and condo boards real-time reserve fund tracking, capital planning, component inventory, and project management — replacing outdated static reserve studies with a dynamic, always-current platform.

Create engaging, interactive presentations effortlessly with Tiled. Enhance your storytelling and captivate your audience with dynamic, customizable content.
Scout Distribution is a craft alcoholic beverage distributor serving California and Arizona, operating since 2018.
Chefs Life was created in early 2021 by celebrity chef Brian Malarkey (a Top Chef alum and San Diego restaurateur).
San Diego-based AI-powered polling and community-forum platform for digital publishers, founded by Scott Kaplan, a longtime ESPN 710 LA sports radio host.

Discover the world's most extraordinary collection of perspective-changing rooms, mind-bending installations, and optical illusions.
Perfect offers patented infusion technology that is licensed to manufacturers to lower costs, improve consistency, and scale across markets for infused pre-rolls by breaking down and reconfiguring plant's own chemical compounds.
Blending a Japanese style whisky that harmonizes Japanese nature and artisanship

SuperMem GrowthOS pairs AI speed with human judgment to provide growth solutions, with real operators closing what AI cannot.
SWASTHAM TRUST supports needful patients by offering diverse medical services, including providing financial aid for cancer treatment and organizing free health check-up camps.

Aurella is a tax preparation engine designed to eliminate manual data entry by automating the journey from client document intake to return-ready output for tax firms.
Healthy Crops is an international research project that aims to achieve significant yield increases for small-scale producers in Africa and Asia by providing disease-resistant rice varieties.

UFLO1, INC. provides an AI-powered learning platform called Uflo that offers tools and services for students, teachers, and institutions to build personalized courses, share content, assess knowledge, and analyze data to tailor instruction.
M&R Technology, Inc. does business as The Infinity Shield and holds a U.S. patent (invented by Magid Fazel and colleagues) for garage-door safety sensors designed to protect pets and family members from accidental door strikes.
Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.
Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

Financial Freedom with Bitcoin. The digital assets partner for your business. OTC, Swaps, and Enterprise-Grade Solutions
RPGMatch, a Los Angeles-based tabletop-gaming matchmaking startup, acquired the long-running gaming community site RPGnet in a 2024 merger, with RPGMatch owner Joaquin Lippincott becoming CEO of the combined company.

AI-Enabled Quality and Regulatory Workflows
Applied Learning Lab partners with educators to co-design tailored solutions that enhance teaching and learning in K–12 settings through curriculum and tool evaluation, curriculum design, and professional learning.
Arc Interactive is a digital ideas studio that focuses on brand and digital strategy, product design, web and social content, and app and web development.
According to its founder's LinkedIn profile, Greenview Labs is a golf technology startup founded by Harrison Fitz.
Founded by Wharton MBA Paul Dohrenwend; its premium sake made its retail debut at a Costco in San Diego.

Craitor builds the production layer for critical hardware, deployed where it is needed, aiming to manufacture sovereignty.
MAPLE FUNG MD INC provides biotech consulting services, including fractional CMO roles and protocol design, and also offers per diem nephrology care and serves as a clinical trial investigator.

Influsence, Inc. provides an AI SaaS platform that offers data insights for influencer marketing to help increase reach, engagement, and revenue for ad agencies and companies.

Condor is an AI-powered platform that unifies clinical, operational, and financial data into a single source of truth for life sciences companies to manage R&D finances.


LinkedIn content consultancy and scheduling platform for busy founders


Sourcify helps brands manufacture products in Asia.


Faster processors for solving NP-complete problems