B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies
CarbonBuilt produces ultra-low-carbon concrete masonry using upcycled, low-carbon binder to replace cement. Affordable and ready for real-world construction.
Grew out of Mick Ebeling's Not Impossible Labs as "Hunger: Not Impossible," a text-message platform connecting food-insecure families with prepaid meals from local restaurants; it later rebranded as Bento.
Butterflies are free to fly

Mote develops technology that recovers both energy and carbon from wood waste to remove CO2 from the air and produce clean hydrogen.

FuzzyBot is a small studio that makes games, including a co-op horror game and a roguelite x lifesim hybrid.

Everest Properties is a privately-held real estate investment firm specializing in acquisition, recapitalization, and asset management of real estate.

Develo Inc. provides AI-native pediatric software built as an operating system for charting, billing, practice management, and family experience for independent pediatric practices.
Headgum is a comedy podcast network co-founded in 2015 by Jake Hurwitz and Amir Blumenfeld (of CollegeHumor's Jake and Amir) along with Marty Michael; its shows include the official jackass podcast hosted by Johnny Knoxville.

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Picogrid delivers integrated systems for modern missions, connecting sensors, platforms, and operators across land, sea, air, and space.

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PT Motion Works, led by CEO Bryan Pate, is the parent company of the ElliptiGO elliptical bike, GIBBON slacklines, and Indo Board, and it landed on the Inc. 5000 list of fastest-growing private companies.

Built to think like a comp expert—trained on your strategy and powered by Compa’s market data to guide every pay decision.

FranCap Corp, powered by CenTech, provides bookkeeping, M&A advisory services, and access to capital for franchisees, specifically mentioning Jersey Mike's.
Comparative, Inc. is the legal entity behind DataGPT, a conversational AI data-analytics product founded in 2021 by Arina Curtis and Darren Pegg.

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Vebu is a company pioneering food automation.
Chamberlain Coffee Inc. provides organic coffee and matcha beverages, along with cold brew, bundles, and accessories.
Theraheart Inc. is a medical device manufacturer dedicated to providing innovative, minimally invasive solutions aimed at improving the lives of Heart Failure patients.
The AI control plane for discovering, securing, and governing AI agents, MCP servers, and AI applications across your enterprise.

Accelerating humanity’s galactic destiny
Leeta Materials, Inc. manufactures ceramic powders and sintered components designed to meet precise industrial requirements for applications in various industries.
Apps to make anything.

We're an ambitious startup developing a groundbreaking new UGC gaming platform.

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STRATEGICALLY BUILDING WHAT THE GRID AND THE CLOUD NEED MOST
Identify complex security vulnerabilities and sensitive data exposures to reduce risk of security incidents and provide assurance to your customers.

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BlueNalu, Inc. develops cell-cultivated seafood, beginning with bluefin tuna toro—crafted with care and produced without fishing.
Cheehoo, an AI 3D-animation startup, was founded by a group of Hollywood veterans including Rideback co-CEOs Michael LoFaso and Jonathan Eirich alongside producer Dan Lin (Netflix's former head of film), and raised $10M led by Greycroft with Point72 Asset Management participating.

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Orbital AI Edge Compute for Next-Gen Space Operations
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Orbee is the automotive data platform that unifies every customer signal so dealerships can activate smarter audiences, run better campaigns, and close more deals.
NB Tech Acquisitions Corp is a California-based company that acquires and develops code-based technology, focusing on high-growth sectors like artificial intelligence, cyber security, and decentralized technologies.
Refraction Point, Inc. is the original incorporated name of LimaCharlie, the SecOps cloud platform founded by Maxime Lamothe-Brassard, who was previously a founding member of Chronicle, Google's cybersecurity venture.
With a focus on long-term value creation, Park Ventures LLC strategically invests in select real estate holdings, development projects and private companies. From Land Investment in high-growth markets to commercial, residential and industrial Real Estate Development projects, we help communities

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Greenfly's short-form media software platform captures, collects, organizes & distributes videos & photos to drive fan engagement.
Founded by CEO Brandon Werber, airVet has raised over $40M in venture funding, including a Series B-2 round led by HighlandX and HighPost Capital.

Explore Starlings

AllVoices is the AI-native employee relations platform for anonymous reports, cases, and investigations. Save hours with AI case summaries and reports.

Xano offers a scalable no-code backend and provides professional backend development for the AI era, enabling users to understand, govern, and run AI-built software.
Founded by Grammy-winning music producer BloodPop (known for work with Lady Gaga and Madonna), the game studio raised $6.5M in seed funding with a team including former Halo, Cyberpunk 2077, and Red Dead Redemption developers.
Provisio Medical Technologies Corp. is dedicated to developing innovative solutions for Peripheral Artery Disease, including an automated, integrated smart-catheter technology called the SLT Platform which includes the SLT FLOW, the world's first and only catheter-based volumetric blood flow measurement intra-procedurally.

Founded by veteran game developer Taylor Kurosaki (formerly of Naughty Dog, Sony, and Activision), the studio received a $100M investment from Korean gaming company Smilegate.
Co-founded by former Microsoft researchers Sadegh Riazi and Ilya Razenshteyn, CipherMode Labs raised a $6.7M seed round led by Innovation Endeavors, the VC firm founded by ex-Google CEO Eric Schmidt.

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Mucho Mas Media is an independent studio that empowers and supports the stories of Latino communities and filmmakers through its global production, financing, and distribution capabilities.

The Realest is an online marketplace for authenticated entertainment memorabilia, using a proprietary witness-based authentication system.