B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies
Delphi builds AAA games based on the most desirable IP franchises in the world
Enterprise AI for finance that thinks and learns like people. VERSES Genius™ is used to manage risk when data is volatile, uncertain, complex & ambiguous.
Tinwell Labs is the legal entity behind Era, an AI-powered wealth management platform co-founded by Alex Norcliffe and Lindsay Brady that has raised roughly $9.4M in funding.

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.
Active Entertainment Texas, LLC provides event planning, film & live production, and event rental services for schools, corporate events, and weddings.

Incite is a venture capital firm that invests in entrepreneurs, provides grants to non-profit organizations, and funds initiatives aimed at changing politics.

Replacing Hearts. Restoring Lives. HEART FAILURE Heart failure is a global epidemic affecting at least 26 million people worldwide, 6.2 million adults in the U.S., and is increasing in prevalence. Heart transplantations are reserved for those with severe heart failure and

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General Galactic builds advanced spacecraft for sustained maneuver and more time on-mission across the space domain

Cognixion develops accessible, non-invasive brain-computer interfaces combining neuroscience, AI, and spatial computing.
STYNGR makes in-game audio seamless with easy SDK integration and flexible monetization options. Elevate your game with fully licensed music from major labels and indie artists.
HypeVR built cinematic volumetric VR capture technology using a 14-camera 6K rig, founded in San Diego in 2015.
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A piezoacoustic platform technology that makes the world’s batteries last longer, charge faster, and be safer.
SmallMolecules.com provides the largest listing of commercially-available small molecule products, assisting researchers to find the products they need to drive discovery.
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Cre8tech Labs does business as Lender Price, a mortgage fintech that received a strategic investment from Regions Bank in 2018.

Transform job-site drawings into actionable tools for tracking every building element from day one.

Build, deploy, and govern autonomous digital workers across revenue, IT, service, and operations. Automate workflows, execute tasks, and scale work with AI-powered digital workers.
MSI is the single platform for medical device cybersecurity compliance — tools, data, and expert support to meet FDA requirements and ship on schedule. 100% FDA approval rate.
Zuub provides insurance verification infrastructure for dental, offering a Dental Insurance Eligibility & Benefits API to turn complex payer information into reliable, product-ready data for applications.
CU Direct Corp, founded in 1994 and now branded as Origence, is a credit union service organization (CUSO) collectively owned by 124 credit union shareholders rather than by venture investors.
Rasa World Group, Inc. provides an all-in-one ecosystem of software and creative services to build, scale, and operate global events and experiences.
Seaboard Corporation manages every aspect of its business from farms and processing plants to container shipping and commodity trading, with roots in grain and agriculturally derived products.

Orbital defense built for scale.

OUTERSPACES INC. PHILADELPHIAS PREMIER DESIGNER AND BUILDER OF LANDSCAPE ARCHITECTURAL ELEMENTS, SWIMMING POOLS, FOUNTAINS, AND OUTDOOR LIVING SPACES.

We build kitchen intelligence tools to cut food waste, eliminate single-use packaging and optimize resources across every stage of food production.
EliseAI is the industry-leading AI platform transforming both property management and healthcare through automation and conversational AI that help housing and healthcare organizations streamline communications and improve operational efficiency.

The infrastructure for the distribution of liquid hydrogen.

Ezra Climate was founded by Dan Rosen and Dori Rutkevitz, who previously helped scale Mosaic, a solar fintech platform that financed over $15B in projects; Ezra raised an $8M seed round for AI infrastructure serving private capital markets.

Talino Fintech Foundry helps technology platforms and enterprises launch secure and compliant fintech products faster with MCP-ready and API-enabled infrastructure.

Stellar Designs, Inc. offers unique, quality promotional products and branding solutions from its office in Anchorage, Alaska.

Discover Bundy Group’s expert investment banking and advisory services, helping business owners achieve growth, strategy, and successful transactions.
PointOne Family Office is a Manhattan Beach-based boutique multi-family office and SEC-registered investment adviser managing roughly $327M in assets.
Dimer Instruments creates instruments that enable real-time molecular analysis at multiple points during the pharmaceutical development process.

Pace News provides breaking news, local news for areas like Inglewood and California, business, health, education, politics, community, law enforcement, lifestyles, and arts & entertainment.
Find an independent primary care provider near you who takes your insurance and has real time to listen. Same-day, evening, and Saturday visits in AZ & WA.

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Koobz, Inc. manufactures custom footwear on-demand with zero inventory, allowing brands to launch their own original shoe designs.
Curb management for cities, airports and fleets. Real-time data. Automated payments. Smart loading zones. Zero emissions delivery zones.
BioProtonics is a pioneering company focused on advancing diagnostic imaging through its Magnetic Resonance Histopathology (MRH) technology. MRH offers a non-invasive, high-resolution method for analyzing tissue microarchitecture during routine MRI scans. MRH

AI-native requirements management for engineers managing mission-critical compliance. Replace scattered docs and manual traceability with a single, audit-ready platform

Detect, decipher, and defend against coordinated narratives with PeakMetrics narrative intelligence.

Live Data Technologies provides live human capital data, including job-change data on professionals, re-verified and compliantly sourced from the open web.

Achieve 30% turbulence reduction, $43 average fuel savings per flight, and 4s alert response times.
Fluxnium's founder and CEO, Jeff Green, previously co-founded Stamps.com in 1996 with Jim McDermott (also a Fluxnium board member) and Ari Engelberg; Green also co-founded Rusheen Capital Management.
Distribution marketing for music, entertainment, gaming, and brands. The AI Engine for virality, generating millions of views monthly.

Jenz is an internal social network that functions as a mobile intranet and an employee engagement app, aiming to transform internal organizational communication and boost company culture.