B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies

Vimcal is the world’s fastest calendar, beautifully designed for people who have too many meetings. Drag to share availabilities, schedule across time zones, and see all your Outlook and Google calendars in one view.
Search engines and social networks are not designed for due diligence. Ferret’s unparalleled AI platform combined with world class information provides you with exclusive relationship intelligence that can help you avoid high-risk individuals and spot promising opportunities.
Four Seasons Sunrooms offers custom home additions including sunrooms, patio rooms, liferooms, louvered roof systems, three-season rooms, pergolas, patio covers, decking, windows, and doors.

Steric provides patent-pending technology that uses electromagnetic energy to transform wine and spirits at a molecular level, optimizing flavor, mouthfeel, and aroma.

Leading the future of the creator economy, Amaze helps creators make products, sell merch online, and increase revenue with cutting-edge commerce solutions.
Just Imagine Toys is the exclusive UK distributor for brands such as Peaceable Kingdom, Sentosphere, and Graine Creative, and also a UK distributor for eeBoo, offering a range of toys and creative kits.
Oxen.ai provides an AI platform for creators and builders, offering tools to generate videos and images, brainstorm with LLMs, organize asset libraries, and deploy custom fine-tuned endpoints.
Autopilot was built by the team behind the viral 'Pelosi Tracker' and lets users copy politicians' and top traders' stock trades; co-founder Brian Schardt has said the app manages roughly $1.8B in tracked assets.

Technology purpose-built for libraries, archives, and museums for improving Access, Searching, Resource Sharing (interlibrary loan) & Digital Preservation.

Learning Explorer, Inc. offers solutions that personalize learning at scale by combining adaptation, automation, actionable assessment, and engagement to help students achieve their growth goals.
Channel Robotics is a surgical robotics company that provides technology allowing surgeons to reach further with robotic surgery.
Petalfast Inc. equips cannabis brands for sustainable success through sales and distribution, integrated sales planning, and infrastructure.
Rypplzz is the 3D positioning infrastructure that transforms telecom networks into spatially intelligent systems, powering the next evolution of the internet.
Elodie Games was co-founded by Riot Games/League of Legends veterans Christina Norman and David Banks, and raised $32.5M in Series A funding backed by Andreessen Horowitz before shutting down in 2025.
Mosh, the brain-health protein bar brand, was co-founded by Maria Shriver and her son Patrick Schwarzenegger, and raised a $13M Series A led by Main Street Advisors.

Measurabl offers comprehensive ESG solutions, empowering businesses with data-driven insights for sustainability & compliance. Learn More

Arena Club, an online sports card marketplace, was co-founded by entrepreneur Brian Lee (co-founder of LegalZoom/ShoeDazzle/The Honest Company) and Baseball Hall of Famer Derek Jeter, and raised a $10M Series A.

ORANGE COMET is a next-generation gaming and entertainment company creating immersive games in partnership with the biggest properties in the world.

Mitico provides an accessible carbon capture technology solution that collects and purifies carbon dioxide at the source post-combustion before it enters the atmosphere.

AquaPoro manufactures water from air for homes and industrial sites with ALMA technology, even in low-humidity conditions.
ElectroStatics, Inc. designs and manufactures products to control static electricity and reduce contamination for industries working with non-conductive materials.
This is not an operating startup but an investment SPV (special purpose vehicle) run by LifeLine Financial Group, a Beverly Hills multi-family office, used to execute targeted investments.
We are wholesalers in Japan who import / export Japanese-made products such as everyday items, cosmetics, snacks and food at wholesale prices.We also offer proxy marketing for Japanese companies as well as wholesalers.
Play Versus Inc. is the legal entity behind PlayVS, the scholastic esports platform founded by Delane Parnell, who stepped down as CEO in 2023 and was succeeded by Jon Chapman.

Gluten free, grain free, vegan cookie dough. Enjoy Doughy raw or baked.

A visual conversation at the speed of culture

AI workers that quote, dispatch, track, and close loads. Phone, email, WhatsApp. 28 languages, 24/7. Runs inside your TMS.

Keeta is a layer-1 blockchain network that connects payment networks. Direct blockchain-to-blockchain transactions are processed with settlement times of 400 milliseconds and a throughput of 10 million transactions per second.

We partner with global industry leaders to craft and deliver groundbreaking consumer electronics and connected solutions.

Meet Charlie, your AI financial coach inside the SUMA app. Get personalized budgeting, savings, and investing advice in English or Spanish.

CLIQ makes the world’s most portable chairs—ultra-compact, quick to set up, and built for everyday adventure. Whether you’re camping, tailgating, or relaxing at the beach, CLIQ chairs offer comfort, durability, and convenience in a sleek, travel-ready design.
Sequence unifies editing, color grading, audio mixing, library organization, and reviews so post-production teams can work better together.

Scale end-to-end influencer, affiliate and referral programs. Empower your customers and creators with cobranded landing pages, cash and store credit rewards, gifts, and much more!

Forge Technology, Inc. supplies metal forming simulation software, provides consulting, training, and technical support, and supplies forging equipment to industrial and academic customers in the United States.

Serenity is a unified EHS platform built on ServiceNow for incident management, audits, risk assessments, compliance, and cyber risk — with AI-powered safety insights.

The all-in-one youth sports management software for registration, payments, scheduling, player development, and communication. Run your whole org in one app.

Organ donation connects a community of people together in a way that nothing else can. At Lifeline of Ohio, our mission is to support and honor that community—including the generous donors who gave the gift of life and the thousands still waiting for a donation.

Automate compliance in life science regulated markets.

Comprehensive compliance platform for broker-dealers and fintechs. Automate CAT/CAIS reporting, best execution analysis, trade surveillance, corporate actions, and data reconciliation.

Austin Fire Systems provides turnkey solutions for fire protection systems, including engineering, construction, and maintenance.
BURL Concepts provides innovative ultrasound solutions to instantly access brain performance and guide clinical interventions.
KRNL, Inc. is the legal entity behind Kernel, the Los Angeles brain-technology company founded in 2016 by Bryan Johnson, the entrepreneur who sold Braintree to PayPal for $800 million and later became known for his Blueprint longevity project.
Concrete AI's Concrete Copilot delivers concrete producers a simple, fast, and flexible decision-making tool to optimize concrete performance, cost-savings, and carbon reductions with AI-assisted concrete designs.

Roundtable Entertainment Holdings, Inc. is a multi-platform production company that creates, finances, and delivers premium IP in Feature Films, Unscripted Content, FAST Channels, and Distribution.

Mozza Foods is developing real dairy casein grown in soybean plants. A drop-in ingredient for dairy manufacturers, produced through plant farming at scale.

Creative teams can share and edit files without uploading, syncing, or worrying about cloud storage limits.
Co-founded by CEO Jeanine Wright, Inception Point AI produces AI-generated podcast personalities at large scale, reportedly publishing thousands of episodes per week across a catalog of over 160,000 episodes.
Boardriders is the ultimate destination for action sports & lifestyle. We connect a global community of dreamers through authentic experiences & the most legendary brands.

RLTY LLC empowers real estate professionals nationwide with services and support, including commission funding, LLC setup assistance, tax preparation and bookkeeping services, and healthcare coverage options.
Also known as FuturHealth, this San Diego weight-loss company was co-founded and is led by CEO Luke Mahoney.

Official website of Cochl
Co-founded and led by CEO Isaac Oswalt; it is a private-equity roll-up platform that acquires and consolidates short-term rental operators while letting the original operators retain equity.
ATEN provides solutions across various markets and applications, offering products like KVM switches, professional audio/video equipment, consumer electronics, and USB solutions.

Pixxel is a space data company and spacecraft manufacturer redefining Earth observation through high-resolution hyperspectral imaging and advanced analytics.