B2B startups in Southern California

MD Revolution was founded by practicing cardiologist Dr. Samir Damani and raised over $30M in funding, including a $23M round.

Professional-Grade Sawhorses, Tool Pouches and Knee Pads for work by ToughBuilt. Strictly for construction workers and electricians who need the best for the job!

Mogul helps artists and songwriters find missing royalties, fix registration gaps with PROs, the MLC, and SoundExchange, and keep more of what they earn.

Co-founded by Kevin Marciano along with Scott Ulliman and Nate Reese; the small studio builds games on Epic's Unreal Editor for Fortnite (UEFN) and was reportedly down to its last few months of runway before its GDC 2023 breakthrough.

The world’s leading platform for packaging and financing independent films, with tools for filmmakers, talent, and investors to connect and succeed.

As leaders in cathode innovation, we develop materials that drive clean energy solutions. Click here to explore our pioneering work in battery technology.

An easy-to-launch mixed reality platform that blends physical and digital experiences for unparalleled fan engagement. Request a demo.

SeeDevice pioneers SWIR (Short-Wave Infrared) vision technology using its patented QMOS™ silicon-CMOS image sensor for applications like ADAS/AV, thermal imaging, 3D depth sensing, and biometrics.

Slips is the next-generation peer-to-peer betting platform where players bet against each other — not the house. Offering Heads Up, Pools, Tourlays, and AI-Generated Predictions, Slips creates a social-first experience where users win, connect, and compete in real time.

Barcode is a plant-based, adaptogen-powered functional beverage for everyday performance.

Gemist.io offers innovative jewelry design and visualization technology to boost sales, engagement, and customer loyalty for fine jewelry brands.

Turn your bread into dough. The Simply Bread Oven and app help bakers at every stage bake more, sell more, and grow a thriving micro-bakery.

Pludo. For a balanced body and mind.

Modern and intuitive avionics. Our hardware and software are designed from the ground up using state-of-the-art UI/UX technology to create beautiful and safe avionics.

Discover Balboa Geolocation's cutting-edge geolocation solutions for defense and commercial markets, ensuring accuracy in challenging environments.

Co-founded by physicists Dr. Massimiliano Di Ventra and Dr. Fabio Traversa alongside serial entrepreneur John Beane, previously a founder of ecoATM; investors include DARPA and Revolution's Rise of the Rest Seed Fund.

Founded in 2018 by Ahmad Malkawi, a wireless-industry veteran with prior stints at AT&T, Qualcomm, and Sprint; the Irvine-based company builds telecom hardware, software, and AI solutions for IoT connectivity.

Play Eggscape, the ultimate multiplayer Mixed Reality game where you battle robots, collect abilities, and create custom levels with up to 4 players. Join the immersive fun now!

LaunchPoint Electric Propulsion Solutions is a propulsion and power generation company supplying lightweight, highly efficient, power-dense, electric and hybrid systems for aerospace, defense, unmanned aircraft systems, and advanced air mobility.

Devign, Inc. is the legal entity behind MightyMeld, a visual React development tool founded by Steven Schkolne; the company has raised roughly $4.1M.

PiLogic is a dual-use company that revolutionizes aerospace by delivering precise, efficient, and mathematically grounded AI solutions for critical dual-use aerospace applications like tracking, diagnosis, and sensor fusion.

Rapid Satellite Payload-Tailored Design

Transphorm, co-founded by Umesh Mishra and Primit Parikh and backed by investors including Google Ventures and KKR, was a Nasdaq-listed company (TGAN) that Renesas agreed to acquire in 2024 to expand its GaN power semiconductor business.

SkySafe’s advanced drone detection system and airspace intelligence platform enables organizations to identify, track, analyze, and act on unauthorized drone activity.

SocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!

Day 4 Night Studios is an independent game development studio that focuses on delivering deeply heartfelt and original games that innovate in storytelling and design.

F42 Corporation is a vertically integrated AI infrastructure company combining sovereign-grade renewable power, world-class data center capacity, and an elite applied-AI engineering workforce for Tier 1 government and enterprise clients.

Incentify is the platform for discovering and managing tax credits and incentives across 1,200+ federal, state, and zone programs with AI-powered eligibility matching and automated compliance tracking.

All In Food makes organic snack bars with high-quality ingredients, and every bar sold helps fund local heroes fighting hunger and supporting nutritious food access initiatives in communities.

Hatsu Labs is an international game studio creating new player experiences.

Children’s healthcare products designed to make sick days more playful. Playhouse MD empowers kids to feel confident and connected — because a dose of play goes a long way.

Powering your mission to the Moon, Mars, and Beyond

Co-founded by Imad Izemrane and Ciarra Pardo; NBA star Russell Westbrook joined the company as an investor and resident curator.

Operates as AlphaLit, founded by Anand Upadhye; raised a $3.2M seed round with angel investors including CLEAR co-founder Ken Cornick and Jason Boehmig.

Also known as Elevate Dynamics; co-founder Daniel Magy previously founded Citadel Defense Company, a counter-drone defense firm that was later acquired by Blue Halo.

GTR helps home service companies grow with referral software, branded apps, and automated rewards. Turn happy customers into your best lead source.

Aervivo enables our Partners to provide community wide Gigabit managed WiFi, delighting the communities they serve and generating an outstanding 100%+ IRR, quickly.

It all started with a single Book of Hope in 1987. Since then, more than 2 billion children and youth worldwide have encountered God’s Word through OneHope’s

ProCode Inc. provides an AI-Powered Medical Billing & Coding Copilot.

Jackpot 16 is a Blackjack-Poker hybrid card game, sold via its own site, Google Play, and eBay.

Kindra is transforming vaginal health and sexual wellness for women navigating their changing bodies and profound hormonal shifts.

Crop Diagnostix uses plant RNA to detect asymptomatic crop stress before symptoms appear. Asymptomatic Agronomy for partners, retailers, and input providers.

Make medication work as intended. Custom Health connects pharmacy, in-home technology, and pharmacist-led care for 98% adherence and improved outcomes.

RightDevice was co-founded by George Kramb and Patrick Frank and later rebranded as PatientPartner, a platform connecting patients with medical device information and providers.

5x Media is a borderless media company that manages, partners, and produces content with creative talent across multiple verticals.

OpenLight Photonics is a company that provides custom Photonic Application Specific Integrated Circuits (PASIC) design enablement, inhouse design, and production using its silicon photonics technology.

Co-founded by Alex Watts, the LA-based startup has raised over $8M, backed by investors including Multicoin Capital.

Founded by AAA gaming industry veterans John Blakely, Matthew Armstrong, Mark Cieslar, and Christopher Sturr, and backed by Menlo Ventures in a $3.4M seed round.