B2B startups in Southern California

Co-founded by Andrew Morris, Eric Brouwer, and Adolfo Velazquez, the company is developing a rapid lung-cancer diagnostic called the verifi LUNG test.

RiskFront provides an AI-enabled risk operating system called AIROS for financial crime risk and compliance operational tasks and workflows, consisting of three Agentic AI Systems: Due Diligence Research (DDR), Transaction Analysis (TXA), and Document Analysis (DXA).

The LA protein-nutrition company is backed by Keurig Dr Pepper and Madison Square Garden Sports, and rebranded its protein soda line as SkyPop.

ATTN: is a media company that builds a business around attention by engaging massive audiences through original social content, original programming, creative shop services, and branded partnerships.

DIG is a rapidly growing studio founded by industry veterans innovating to define the future of Gaming.

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AMBYTECH is an IT consulting and digital transformation company based in Paris that assists large enterprises and the banking sector with their digital transformation.

Toro Neurovascular develops advanced stroke devices, specifically catheter technology, for the treatment of ischemic stroke.

Banyan provides a receipt data platform that unlocks and activates item-level receipt data to power commercial and consumer applications.

Sandbox Studios invests in celebrity brands.

Shadow Shifts is a workforce management platform for the construction industry, used to schedule shifts, dispatch crews, and track time.

Soleic technology is the world's first fully biodegradable, high performance polyurethane material. Plant-based. Zero microplastics.

AgBlox is an AI platform that predicts agricultural commodity prices.

Strengthen care and improve patient outcomes by prescribing a healthier lifestyle

Eydle operates accredited application security verification infrastructure aligned with enforcement frameworks across mobile, web, and cloud ecosystems.

Miren.co is a commercial brokerage firm focused on building vibrant communities through creative resources, offering tenant representation, landlord representation, and investment sales.

Qolab is a quantum hardware company that engineers industrial-grade superconducting QPUs (quantum processing units) for useful computation through advanced semiconductor manufacturing.

Telesair, Inc. is a non-invasive ventilation manufacturer. We enable respiratory care in any setting through high-flow oxygen generation and portability.

Through its health & fitness AI platform, PEAR creates personalized digital coaching experiences to help people move smarter, get healthier, and live happier.

Mansa is a streaming platform that showcases new talent and veterans with stories from across the globe, and connects viewers with its “Watch Out Loud Feature” and creators to audiences with Web3 features.

Priwall helps you find and remove your personal data from data brokers. Protect your identity and reduce your digital footprint.

Professional AI voice generator for real production workflows, with free testing and flexible integration for studios and media teams.

Self Inspection uses AI trained on 20M+ images to automate vehicle damage detection, condition reports, and CR scoring — built for dealers, fleets, rentals, and lenders.

Founded by Itai Hirsch and Stacy Abraham (CEO), per its SEC Form D filing and Crunchbase profile.

Option-based portfolio strategies for RIAs and institutional investors — risk-managed income, growth with loss limits, and VOLT™, our tax-smart option overlay for concentrated stock.

MDFZ, LLC is a wholly owned subsidiary of Legion M Entertainment, the self-described "world's first fan-owned entertainment company," per Legion M's SEC offering filings.

Zymbit Resilient Edge Stack makes Linux devices more secure, reliable and recoverable. Trusted software and hardware that grows with your business.

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Founded in 2023 by games-industry veterans J Aaron Farr, M Yichao, and T Carl Kwoh (with backgrounds at Riot Games and Wizards of the Coast), the studio raised a $3.15M seed round led by London Venture Partners.

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SHOP DIDDO, INC. describes itself as "Diddo - Agentic Commerce".

AI-native agents for complaints, QA, and CX that help financial institutions automate compliance workflows and improve customer experience.

Parrot imagines, designs and builds more innovative drones every day to offer you the best flying experience.

A beautiful wave - turning spaces into stories and moments into lasting memories.

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CCG Lab Inc. develops digital Collectible Card Games on its proprietary engine, allowing fans to create deep relationships with entertainment brands.

The SEC filing entity for Rubbl, a heavy-equipment rental marketplace based in Encinitas, CA and co-founded by CEO Adam Greenberg; has raised $2.5M.

GEENEE AR provides WebAI solutions for interactive virtual try-on, AR mirrors, and immersive XR experiences that transform retail, fashion, and entertainment.

The Future of Music Should Feel Human

Moonware builds the AI systems that run ground operations. HALO, its Ground Traffic Control™ solution, gives airlines, handlers, and airports control over turnarounds, gate-in to gate-out.

Co-founded by Caltech chemist Brian Stoltz and UCLA oncologist Dennis Slamon, known for co-discovering the HER2-targeted breast cancer therapy Herceptin; the company is backed by Kairos Ventures.

Founded in 2014 by Patrick Henry, Farooq Anjum, and Jeff Campbell, the agtech soil-sensor company was acquired by Goanna Ag in August 2025.

Options MD was a telehealth company for treatment-resistant depression, connecting patients with providers for options like ketamine-assisted therapy and TMS.

Deploy CX agents faster and safer with a stack built for public websites, service journeys, backend systems, and the realities that stall major AI launches.

Growthsayer was founded by Phillip Geltman, a San Diego-based supply chain specialist who originally built the platform to optimize cannabis industry supply chains before expanding into broader retail demand planning.

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