B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies

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Hualapai Ventures, a Beverly Hills-based entity, has been reported as the front company behind TKO Group's (UFC/WWE parent) new boxing league venture.
Atmosphere DC Holdings LLC provides data centers and AI factories that are designed for AI, ML, cloud, and enterprise workloads, with a focus on sustainability, innovation, and efficiency.
Hauler Hero is a waste management software solution that helps waste haulers improve their operations, increase efficiency, and reduce costs.

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SAFR Football Helmet Covers reduce the external blunt force that can cause traumatic brain injuries for all ages. Learn more!
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Kleverness Hospitality offers intelligent automation technology that combines style, comfort, and energy efficiency for hotels, buildings, and offices.

Specialty mushrooms grown on our family-operated farm in the Arts District, Los Angeles. Wholesale for chefs and restaurants, plus dual extract tinctures.

Streamline your functional health business with Biocanic to get better better scale and outcomes for you and your clients.
ZUUM Transportation is a logistics technology company that develops a comprehensive logistics platform including ZUUM Automated Broker for freight brokers to digitize operations and ZUUM BEYOND TMS for shippers.
Gales Inc. sells shoes for nurses for both women and men.
"The point is to get missions out of the door as fast as possible. Even two to three years is too slow” - Major Gen. Stephen Purdy,US Space Force We solve the long-lead parts problem that has plagued the space industry for decades. Learn More Contact Us

Bedrock Servicing provides a hybrid operating model for private credit lenders. We combine institutional-grade loan servicing with proprietary technology to automate complex asset management, ensure audit-readiness, and eliminate administrative friction.
MoveJoy, Inc. provides an AI receptionist service for movers that quotes, books, and closes jobs.
Lucendi develops AI-enabled smart measurement systems that redefine micro-object characterization through cost-effective and high-performance computational microscopy technology coupled with big data and machine learning.
MET Biotechnology, a Culver City developer of extracellular-vesicle therapeutics founded by Ting-Hsiang Wu, came out of UCLA's Magnify Incubator at the California NanoSystems Institute.
Roanoke City Public Schools (RCPS) provides educational services and resources for students, families, and the community, including academic programs, special education, and various support departments.

Rustbelt Industries, LLC handcrafts exceptional custom furniture, including tables, desks, and case goods, for hospitality, commercial, and residential projects.
Ownors was co-founded by attorney James Jones Jr., who previously co-founded and ran the legal-services startup Court Buddy, which was later acquired.
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Adaya invents AI products and builds every layer of them end to end, including the model, the agent, and the design.

A28 Therapeutics is a clinical stage biopharmaceutical company developing a novel platform technology to treat multiple cancer types
Atlas Financial Services offers equipment financing options for new or used equipment, working capital, vendor programs, and merchant cash advances.
OptzzChain, doing business as Warehouse Exchange, is a Los Angeles company co-founded by Dan Pimentel and Jonathan Rosenthal that raised capital through a StartEngine equity crowdfunding campaign.
An AI strategy and operations firm for wealth and asset managers. Built and run by senior operators.

Join 9Zero, a climate innovation hub for founders, investors, scientists, and innovators. Explore memberships, events, and workspace in SF and Seattle.
Tap Systems was founded in Pasadena in 2015 by Dovid Schick and Dr. Sabrina Kemeny to build the Tap wearable finger-tap keyboard and mouse.

BarrelRM transforms liquor production through data-driven precision. Cut costs, boost margins, and scale faster—without sacrificing flavor or quality.

Real Sounds, Synced in Seconds. 200,000+ human-recorded SFX matched to picture. Try Lana free.

Spice World offers a full line of products from fresh garlic, minced garlic, and squeeze garlic as well as fresh ginger and shallots.
Bridging international capital and know-how with African talent and enterprise since 2004, Helios Investment Partners manages funds totalling c. $3 billion.
A women-founded (Nicole King and Stacy O'Neil) Hollywood talent management agency backed by Shamrock Capital, representing filmmakers such as Tina Satter.


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Commander is a sales intelligence platform that makes waste haulers

The Courtside Group is a Dallas-Fort Worth marketing agency specializing in strategic video, photography, web design, and branding to scale your business.
Review medical records in minutes, not days. Our AI-powered software creates instant summaries and chronologies so you can focus on what matters.
QuAIL Technologies Inc. is a Web Design and Development Company focusing on eCommerce and Custom Web Solutions, including eCommerce Web Development, Web Apps, SEO/SMO, and Software Solutions.
Metaverse Law is a law firm that exclusively focuses on Privacy, AI, and Cybersecurity Law, helping companies navigate data protection, AI governance, risk, and compliance challenges across the digital economy.

Real-time industrial intelligence The data engine for Industry 5.0
Prologue Entertainment is a film and TV production company behind Netflix's A House of Dynamite (2025) and Zero Day (2025).
Coop Records Music