B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies
ClearPrice Networks, Inc. connects payers and providers directly, transparently, and electronically to eliminate rebilling vendor markups for DME, Orthotics & Prosthetics, Medical Supplies, and Home Care Services.
Convexa invests in early-stage/growth technology companies that promise to deliver high growth and exceptional returns.

Aurella is a tax preparation engine designed to eliminate manual data entry by automating the journey from client document intake to return-ready output for tax firms.
Healthy Crops is an international research project that aims to achieve significant yield increases for small-scale producers in Africa and Asia by providing disease-resistant rice varieties.
Invest in startups and early-stage companies on StartEngine. Browse pre-IPO opportunities, buy shares in growing businesses, and build your portfolio with as little as $100.

Okogen, Inc. is a clinical stage ophthalmic pharmaceutical company focused on developing a comprehensive treatment for both bacterial and viral acute infectious conjunctivitis.

Elevate your brand’s story with Utopic
Atticus helps clients obtain Commercial Equipment Leasing and Financing and provides objective advice on all aspects of equipment or vehicle leasing.

UFLO1, INC. provides an AI-powered learning platform called Uflo that offers tools and services for students, teachers, and institutions to build personalized courses, share content, assess knowledge, and analyze data to tailor instruction.
FLAGD Golf, Inc. provides products that deliver real-time yardages to every target on a golf range using GPS technology.

Industrial CO2 Removal & Critical Metal Recovery: By harnessing Earth
M&R Technology, Inc. does business as The Infinity Shield and holds a U.S. patent (invented by Magid Fazel and colleagues) for garage-door safety sensors designed to protect pets and family members from accidental door strikes.
Turning billions of everyday devices into the Internet
Founded by Steve Bedrossian, a Los Angeles-based entrepreneur, per SEC Form D filings and his LinkedIn profile.
FistBump Sports is a free-to-play sports prediction app where users can make predictions, challenge friends, earn coins, and win real sports cards and memorabilia.
Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.

Simba Technologies offers an AI-enabled field data platform that helps nonprofits, funders, and social enterprises collect field data using WhatsApp surveys.
CalEthos is a publicly traded OTC company (ticker GEDC) that renamed itself TerraVolt Holdings and pivoted into data center land banking and infrastructure development, including a planned campus in California's Lithium Valley area.

Solace is the real-time data platform for the enterprise — one platform that connects every application, cloud, partner, and edge, turns raw events into real-time context, and powers agentic AI in production.
Eyeballs Financial, LLC offers the Eyeballs app, which provides up-to-date information on a financial portfolio with instant communication to an advisor.

Founded by Savannah James (LeBron James's wife) with business partner April McDaniel; the women's membership community launched in June 2024 with about 100 members paying $250/month, per Fortune and Harper's Bazaar.

Inherence provides "Proof of Conduct" for the agent economy, enabling autonomous compliance for stablecoins, vaults, prediction markets, and autonomous finance by enforcing rules and policies before transactions execute.
Founded by Wendy Burton in 2015, World Tree has been described as the most successful female-founded company on the Wefunder equity crowdfunding platform, having raised funds through both Wefunder and StartEngine to plant Empress hardwood trees with farmers.

Tiger Pig Entertainment is a full-service entertainment media company specializing in development, production, and IP acquisition/licensing for film and television, also assisting storytellers and filmmakers in finding financing for their projects.
Hygiene IQ, LLC offers industrial cleaning services, sanitation and disinfection, validation and compliance support, and contamination control training and consultancy for various environments including industrial machines, heavy equipment, food processing plants, offices, stores, and cooking areas.
AARMY was founded in 2018 by celebrity trainer Akin Akman along with actress Angela Manuel-Davis and advertising executive Trey Laird.
Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

Bristlecone is the leading provider of connected logistics solutions, including AI applications, SAP integration, and more.

Financial Freedom with Bitcoin. The digital assets partner for your business. OTC, Swaps, and Enterprise-Grade Solutions

Peanut Butter Bombe LLC appears to be a brand identity for SKIPPY® peanut butter, offering various peanut butter products, recipes, and related content.
Arya Worldwide Entertainment LLC is involved in film production and distribution.

Cinedept is a full-service creative production department for brands and agencies, delivering video + photo campaigns, branded content, and social-first assets, and also operates a 6,000 sq ft Virtual production stage and studio.


Renu Environmental Inc. employs proprietary molecular recycling technology to reverse plastic waste to its molecular building blocks, enabling the creation of new polymers for true plastic circularity.
RPGMatch, a Los Angeles-based tabletop-gaming matchmaking startup, acquired the long-running gaming community site RPGnet in a 2024 merger, with RPGMatch owner Joaquin Lippincott becoming CEO of the combined company.
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MyVillage, Inc. leverages culture and technology to convert community wisdom into knowledge repositories for students by collecting advice, stories, and history of local communities and families, using AI and LLMs to create knowledge repositories, and developing opportunities for families and communities to share their knowledge.
Smart Capital provides independent financial advisory services focused on capital management, protection and long-term value creation.

TrueRelief is an FDA-cleared, non-invasive medical device that delivers an electroceutical treatment that uses a patented combination of high frequency electrical current delivered dynamically by a skilled medical professional. The treatment itself is completely painless.
We are an agile solutions company
Explore Artificial Genius for cutting-edge AI solutions that redefine engineering and enhance enterprise productivity.
The Lambrick Group is the company behind Cajole, a social-challenges platform, founded by David Levy and Morgan Conrad and based in Hollywood, California.