B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies
Los Angeles film/TV development company founded in 2022 by Ina-Alice Kopp and William Andrew Mundell; it is developing Mae Ngai's nonfiction book "The Lucky Ones" for film and TV.
Los Angeles company doing business as "Kirra" (kirralife.com), co-founded by Amanda Li-Paige.
Ranked is an AI-powered engine and activation platform that deploys experts and creators to deliver authentic engagement for brands and to empower democracy by connecting local, expert creators who share important videos about their local communities.
San Diego-based AI-powered polling and community-forum platform for digital publishers, founded by Scott Kaplan, a longtime ESPN 710 LA sports radio host.

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Little Black Book (LBB Network) is an invite-only referral app for trusted personal and professional service recommendations.

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Annie Health builds technology that helps hospices measure and improve the quality of care they deliver, and automatically communicates patient outcomes back to referral sources to drive differentiation and growth.

Timecap is a customizable habit tracker application designed to help users build healthy and productive habits.
ArcScore empowers athletes, schools, and brands with AI-driven insights to maximize NIL opportunities and build authentic partnerships.
Orka Beverage was co-founded by Michael Moriarty and Nash Hale and is backed by investors including Air Venture Partners, OpenSky Ventures, and SuperAngel.Fund.

The Vesteck Inc Endosuture Aneurysm Repair (ESAR) platform, Suture-Tight™, is revolutionizing the aneurysm repair space.

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Uscape Apparel LLC creates localized lifestyle apparel for collegiate, destination, and custom markets.
Trillium Lane is a Tech, Media and Entertainment Fund that invests in high-growth creative properties across film, TV, gaming, and licensing.

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Squeeze Software, Inc. provides forward-thinking IT for businesses.
Perfect offers patented infusion technology that is licensed to manufacturers to lower costs, improve consistency, and scale across markets for infused pre-rolls by breaking down and reconfiguring plant's own chemical compounds.

ThermoShade Solutions uses patented shade panels with passive cooling technology to make outdoor spaces feel cooler, addressing extreme heat in various settings like cities, farms, schools, and sports events.

ARwall redefines XR filmmaking with proprietary tools that simplify LED stage management, virtual production, and creative control.
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AI phone agents that call, qualify, and route your leads in under a minute. Built-in CRM integrations for insurance, legal, financial, and medical businesses.
Superliner Express, LLC provides student transportation services, committing to giving children a safe and enjoyable ride to their destination.
Co-founded in 2016 by Matthew Geller, Jared Kapela, and Patrick Lennon; the company has been backed by Techstars.
Cloudweaver helps users build and manage their own world-class data and analytics platform in the cloud by providing tooling to automate tasks, manage spend, accelerate innovation, and improve security across multi-cloud landscapes.

SuperMem GrowthOS pairs AI speed with human judgment to provide growth solutions, with real operators closing what AI cannot.

Be Afraid Media is a horror-first media company building brands across digital, audio, film and television, licensing, and commerce. Home of Dread Central, Be Afraid TV, and the Be Afraid Podcast Network.
GT Optics provides custom optical design, engineering, and manufacturing for biomedical and photonics applications.
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EFAS Technologies revolutionizes water leak detection with its groundbreaking solution, the Global AI Leak Locator (GAILL), which uses AI-Powered Software for Detecting & Localizing Anomalies in Water Systems.
SWASTHAM TRUST supports needful patients by offering diverse medical services, including providing financial aid for cancer treatment and organizing free health check-up camps.
Ionava provides a financial preparedness system that rewards users for being healthy by offering a 'Vault' of reserved cash for major health events and a 'Wallet' for everyday wellness spending, with a portion of the subscription earning interest.
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Celia Group, Inc., through Celia Health and CeliaRx, provides longevity-first telehealth services with personalized, proactive care, offering programs and pharmaceutical-grade peptides designed for health optimization.

Simon AI is an agentic marketing platform with an AI-first CDP that helps marketers create personalized campaigns grounded in live customer data and real-world signals.

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Neatolabs delivers automation, robotics, and product personalization solutions that streamline manufacturing, marking, and fulfillment at scale.
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AdHoc Studio is an award-winning team of interactive storytellers that makes story-driven games, including their debut title "Dispatch."

Lyve Studios Inc. offers end-to-end live shopping solutions for brands, encompassing production studios, expert hosts, software, and signal, to create engaging and converting live commerce experiences.
DeepCast, Inc. provides an AI SaaS platform that helps engineers and scientists build practical models, integrate diverse data sources and tools, and create digital twins for product development.

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