B2B startups in Southern California
Business software and services sold to other companies. The largest single category of startup across Southern California, spanning sales tools, vertical operating systems, and everything in between.
It's the largest category here by far, and one of the most varied — the best-funded names span Shield AI's defense-focused autonomy software in San Diego, Metropolis Technologies' AI-powered parking infrastructure in Santa Monica, and Impulse Space's in-space transportation services in El Segundo. What ties them together isn't a shared product category, just a shared buyer: another business, not a consumer.
Companies
Mansa Micro is linked to Mansa, the LA-based streaming/microdrama platform co-founded by actor-filmmakers David Oyelowo and Nate Parker and backed by MaC Venture Capital.

KAI Media is the Next Generation Fan-Centric Entertainment Company for All K-pop Fans Worldwide.
Better Spirits creates canned tequila cocktails under the brand Baila, made with 100% agave tequila blanco, coconut water, real juice, and sparkling deep well water.

We are on a mission to change the path to power and influence in a tech-enabled world by launching a generation of diverse tech talent into the tech ecosystem.

Stagediver sells merchandise including t-shirts, hats, and vinyl records related to the music of "STAGEDIVER."
Black Unicorn Factory is an accelerator that enables small businesses and founders to access the stock market and raise capital through going public.

At Higala, we are committed to making digital financial infrastructures resilient, modern, and inclusive for financial institutions, businesses, and individuals everywhere.
Jennifer McKay Design Inc. was the original entity behind what is now DefineMe, the natural fragrance brand founded by Jennifer McKay Newton in Santa Monica.

Empowering women’s sports through inclusive, community-driven institutions built for this moment in history.

The Anthropocene Project aims to drive awareness around the impact of humankind on the Earth, through scientific reasearch, film, photography, virtual and augmented reality.
Thumb Technologies, an Irvine, CA conversational-analytics startup, was co-founded by Jae Chung (previously at Amazon and Autodesk) and Daniel Kopeinigg.

NMBLR helps enterprises build, own, and scale AI across their organization. Get the foundation, capabilities, and systems to drive real outcomes with AI.

Using Clinical Insights to Guide Patient Traffic Flow — DEPTH™ accelerates care velocity across the patient journey through Augmented Surveillance Intelligence.
Shreenika Pioneering Inc. creates high-performance, cost-effective chemicals through biotechnology for various industries, aiming to make sustainability an easy economic choice.

Type III, Inc. designs and manufactures advanced mobility and communications hardware and accessories, offering engineering consulting and contract manufacturing services.
Ever Scouts (formerly Legends Lab) is a confidence-building app for kids built around stories of historical figures paired with workouts.
Berri creates organic, plant-based electrolyte drinks designed for clean hydration and active living. No artificial ingredients—just powerful, natural performance.
For the ones who believe fun comes in all forms, there’s Improv Cocktails.Our full-flavored, premium non-alcoholic cocktails taste like the real deal, but without the booze. They’re ready to enjoy if you’re going dry, and ready to spike if you’re not.
This entity operates The Pad Climbing's Santa Barbara gym; the climbing-gym chain was founded in San Luis Obispo in 2002 by Kristin and Yishai Horowitz.
This is an investment special-purpose vehicle (SPV) run out of Beverly Hills by LifeLine Financial Group, a multi-family office, rather than an operating startup — it filed a Form D exempt-offering notice with the SEC in July 2025.
Double Gold Holdings provides fine beverages from around the world, crafted by artisans and maestros, with a mission to be a first-in-class international adult beverage sales & marketing company that builds premium brands responsibly.

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.

PIMCO is an investment management firm providing solutions for institutions, financial professionals and millions of individuals worldwide. Learn more.
Make a hard decision, end to end.

At Datum Technologies Group, we are industry veterans with expertise in managed services, technology project delivery, and global workforce solutions.
We offer portable pitching mounds, portable game pitching mounds, portable practice pitching mounds, regulation game mounds, and fiberglass game mounds for Little Leagues, Babe Ruth and Senior Leagues in Iowa, Texas, California and the entire U.S.
NFTco was founded by serial entrepreneur Niel Robertson (previously of Trada and Newmerix), based in West Hollywood; the company later rebranded as 'Based,' an NFT trading platform, with Adam Lurie as CEO.

SpotlightNews is the news app built for Gen Z. Access 400+ trusted publishers—paywall-free, ad-light, and gamified to spark lifelong news habits.

Joint Venture Media offers a full range of marketing services designed to help businesses grow.

Shop organic & gluten-free pasta made in Italy with clean, simple ingredients. Bronze-die & slow-dried for authentic texture. Curated by Giada De Laurentiis.
Abbott creates innovative medical devices and healthcare solutions for cardiovascular health, diabetes management, diagnostic testing, nutrition, chronic pain and more.
ViroMissile is developing the world’s first truly intravenously-delivered viruses that target and kill tumors.

Experience high-energy HIIT workouts & group fitness classes in California & Texas. Training Mate blends fun, intensity & results for every fitness level.
This is a special-purpose investment vehicle tied to Crosscut Ventures, a Santa Monica VC firm that has shifted its focus to frontier technology investments in space, defense, and energy transition.

Safeguard your digital memories with Kwillt. Securely store and share photos, videos, and stories with your family for generations.
Terafiber was founded by Jim Hanley, a San Diego fiber-infrastructure entrepreneur who had previously founded Netly Fiber, another citywide fiber-network builder, before starting Terafiber in 2023.

Mobile fundraising platform for nonprofits with compliant text messaging, Text-to-Give, and donor engagement. Trusted by 1,000+ organizations.
Aynak is an online store that sells eyeglasses, sunglasses, computer glasses, power sunglasses, and reading glasses.
Aerofex provides pure thrust vectoring for propeller driven craft at rates capable of vehicle stability and control, through its TVP technology.

Salon Republic is the industry leader of modern salon suites for rent for beauty professionals. Join our community - the place to go for salon rental space.

Gensee builds practical control infrastructure for AI operating across real developer and production environments by evaluating AI requests, granting narrowly scoped authority, mediating privileged effects, and recording what actually happened.

World Tree grows Paulownia hardwood through regenerative forestry in partnership with farmers across the Americas.
Encant AI was founded by Scott Dacko (a writer/director/producer before starting the company) and is bootstrapped rather than venture-funded, reportedly reaching around $220K in ARR.

SmartProperty's Living Reserve Study gives HOA and condo boards real-time reserve fund tracking, capital planning, component inventory, and project management — replacing outdated static reserve studies with a dynamic, always-current platform.
Zoodikers Consulting is a content marketing, business strategy, and thought leadership agency that helps organizations communicate with their audiences and achieve strategic objectives.
We help build happy and excellent organizations in the Philippines

Fabels Hospitality East, LLC, operating as GENUINE Hospitality, provides comprehensive hotel asset management for third-party ownership, focusing on revenue generation, operations, human resources, and finances.