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San Diego

401
companies
$25.78B
total raised
B2B, Healthcare, Biotechnology
top industries
Photo: Jon Sullivan · Public domain

The breakdown

401 startups on file in San Diego, spanning B2B, Healthcare, Biotechnology, 366 of 401 have disclosed funding, $25.78B combined, 78 at Series A stage, founding dates span 1985-2026.

A bit of history

The city courted the U.S. Navy in the early 1900s, and Naval Base San Diego opened in 1922, planting the military and engineering roots the region still runs on. UC San Diego professor Irwin Jacobs founded Linkabit in 1968 and later Qualcomm in 1985, inventing wireless technology at the heart of 3G and 4G. A few miles away, fellow UCSD professor Ivor Royston launched Hybritech in 1978, the region's first biotech company. San Diego is now one of the world's top biotech clusters.

Startup & tech events in San Diego

Investors headquartered in San Diego

FusionX VenturesEarly-stage
TVC CapitalGrowth Equity
Qualcomm VenturesSeed through growth (primarily Series A and Series B)
S32Early to growth-stage
$984K
Improv Beverages, Inc.
San Diego, CA · Founded 2022

For the ones who believe fun comes in all forms, there’s Improv Cocktails.Our full-flavored, premium non-alcoholic cocktails taste like the real deal, but without the booze. They’re ready to enjoy if you’re going dry, and ready to spike if you’re not.

B2B
$955K
Lytng, LLC
San Diego, CA · Founded 2023
B2B
$940K
UCSD Surgical Center of San Diego, LLC
San Diego, CA
Healthcare
$900K
DOUBLE GOLD HOLDINGS, INC.
San Diego, CA · Founded 2024

Double Gold Holdings provides fine beverages from around the world, crafted by artisans and maestros, with a mission to be a first-in-class international adult beverage sales & marketing company that builds premium brands responsibly.

B2B
$773K
Terafiber, LLC
San Diego, CA · Founded 2023 · ~11-50 employees

Terafiber was founded by Jim Hanley, a San Diego fiber-infrastructure entrepreneur who had previously founded Netly Fiber, another citywide fiber-network builder, before starting Terafiber in 2023.

B2B
RallyCorp, Inc. hero photo
$770K
RallyCorp, Inc.
San Diego, CA · ~11-50 employees

Mobile fundraising platform for nonprofits with compliant text messaging, Text-to-Give, and donor engagement. Trusted by 1,000+ organizations.

B2B
Series A$750K
Alderbuck Energy, Inc.
San Diego, CA · Founded 2024

Alderbuck Energy is modernizing power distribution with solid-state transformer technology built for the electricity demands of AI, EVs, and the modern grid.

Series AIndustrials
GenseeAI Inc. hero photo
$750K
GenseeAI Inc.
San Diego, CA · Founded 2024

Gensee builds practical control infrastructure for AI operating across real developer and production environments by evaluating AI requests, granting narrowly scoped authority, mediating privileged effects, and recording what actually happened.

B2B
$735K
Southeast Idaho Storage 1, LLC
San Diego, CA · Founded 2025
B2B
SmartProperty, Inc. hero photo
Seed$725K
SmartProperty, Inc.
San Diego, CA · ~11-50 employees

SmartProperty's Living Reserve Study gives HOA and condo boards real-time reserve fund tracking, capital planning, component inventory, and project management — replacing outdated static reserve studies with a dynamic, always-current platform.

SeedB2B
Pacific Integrated Energy, Inc. hero photo
Series A$720K
Pacific Integrated Energy, Inc.
San Diego, CA

Pi Energy has developed innovative technology that combines standard and novel components to create flexible silicon solar that can be ultra-thin, easily installed on most surfaces, and can capture more energy per day than conventional silicon PV.

Series AIndustrials
Seed$700K
LJ Watershed LLC
San Diego, CA · Founded 2023

LJ Watershed LLC is the legal entity behind "Watershed," the restaurant concept from chef Drew Deckman, per Crunchbase.

SeedConsumer
Series A$660K
Browser bets inc
San Diego, CA · Founded 2025
Series AB2B
$650K
MHP Partners, Inc.
San Diego, CA · Founded 2025
B2B
Berman Medical, Inc. hero photo
Series A$607K
Berman Medical, Inc.
San Diego, CA · Founded 2024

Berman Medical is building the image-guided navigation layer for point-of-care procedures to make patient-specific 3D visualization and navigation accessible.

Series AHealthcare
Tiled, Inc. hero photo
Series A$600K
Tiled, Inc.
San Diego, CA

Create engaging, interactive presentations effortlessly with Tiled. Enhance your storytelling and captivate your audience with dynamic, customizable content.

Series AB2B
Vetmab Biosciences, Inc. hero photo
Seed$575K
Vetmab Biosciences, Inc.
San Diego, CA · Founded 2022

Developing Life-Changing Therapeutics For Our Pets Monoclonal antibodies (mAbs) for modern veterinary practices Developing Life-Changing Therapeutics For Our Pets Monoclonal... Read More

SeedHealthcare
Seed$568K
Scout Distribution AZ, LLC
San Diego, CA · Founded 2022

Scout Distribution is a craft alcoholic beverage distributor serving California and Arizona, operating since 2018.

SeedB2B
$555K
CHEFS LIFE CO, LLC
San Diego, CA · Founded 2020

Chefs Life was created in early 2021 by celebrity chef Brian Malarkey (a Top Chef alum and San Diego restaurateur).

B2B
$500K
Serinity, Inc
San Diego, CA · Founded 2026
B2B
$500K
Revital Clinical Nutrition, Inc.
San Diego, CA · Founded 2025
Healthcare
$450K
Delta-S Energy, Inc.
San Diego, CA · Founded 2024
Industrials
Persperion Diagnostics Inc. hero photo
$450K
Persperion Diagnostics Inc.
San Diego, CA · Founded 2022 · ~11-50 employees

Explore Persperion for innovative sweat sensing technology and metabolic health monitoring at your fingertips.

Healthcare
Pre-Seed$425K
International Boardriders League LLC
San Diego, CA · Founded 2022
Pre-SeedB2B
$392K
Sided, Inc.
San Diego, CA

San Diego-based AI-powered polling and community-forum platform for digital publishers, founded by Scott Kaplan, a longtime ESPN 710 LA sports radio host.

B2B
MOI San Diego, LLC hero photo
Seed$390K
MOI San Diego, LLC
San Diego, CA · Founded 2022

Discover the world's most extraordinary collection of perspective-changing rooms, mind-bending installations, and optical illusions.

SeedB2B
$380K
Daedalus Medical Solutions, Inc.
San Diego, CA · Founded 2020
Healthcare
$350K
Angarak, Inc.
San Diego, CA · Founded 2019
B2B
Seed$318K
Perfect Herbal Blends, Inc.
San Diego, CA · Founded 2019

Perfect offers patented infusion technology that is licensed to manufacturers to lower costs, improve consistency, and scale across markets for infused pre-rolls by breaking down and reconfiguring plant's own chemical compounds.

SeedB2B
$310K
Brain Bioenergetics Inc.
San Diego, CA · Founded 2024
B2B
HOME CARE PLACEMENT LLC hero photo
Seed$310K
HOME CARE PLACEMENT LLC
San Diego, CA · Founded 2021

Our mission is to provide a compassionate, world-class customer experience to the families we serve.

SeedHealthcare
$300K
KAMIKI GLOBAL INC.
San Diego, CA

Blending a Japanese style whisky that harmonizes Japanese nature and artisanship

B2B
SuperMem Inc. hero photo
Seed$300K
SuperMem Inc.
San Diego, CA · Founded 2019

SuperMem GrowthOS pairs AI speed with human judgment to provide growth solutions, with real operators closing what AI cannot.

SeedB2B
Seed$275K
Swastham, Inc
San Diego, CA · Founded 2026 · ~11-50 employees

SWASTHAM TRUST supports needful patients by offering diverse medical services, including providing financial aid for cancer treatment and organizing free health check-up camps.

SeedB2B
HAVYN LLC hero photo
Seed$260K
HAVYN LLC
San Diego, CA · Founded 2023

We believe that everyone - including those with sensitivities and allergies - should be able to enjoy fragrance. Our non-toxic fragrances are formulated to be free of all 82 EU fragrance allergens and top 9 food allergens, on top of being free from hormone disruptors and carcinogens.

SeedConsumer
Cybele Microbiome, Inc. hero photo
$252K
Cybele Microbiome, Inc.
San Diego, CA

Unlocking the microbiome for better skin health The Human Body Relies On The Microbiome For: Inflammation Control Infection Protection Wound Healing And More The Microbiome Cannot Be Ignored For over 100 years, "skincare" has often treated

Healthcare
AurellaAI, Inc. hero photo
$250K
AurellaAI, Inc.
San Diego, CA · Founded 2026

Aurella is a tax preparation engine designed to eliminate manual data entry by automating the journey from client document intake to return-ready output for tax firms.

B2B
Seed$250K
Healthy Crop, Inc.
San Diego, CA

Healthy Crops is an international research project that aims to achieve significant yield increases for small-scale producers in Africa and Asia by providing disease-resistant rice varieties.

SeedB2B
UFLO1, INC. hero photo
$200K
UFLO1, INC.
San Diego, CA · Founded 2024

UFLO1, INC. provides an AI-powered learning platform called Uflo that offers tools and services for students, teachers, and institutions to build personalized courses, share content, assess knowledge, and analyze data to tailor instruction.

B2B
$200K
BXNG Holdings LLC
San Diego, CA

Operated as "The BXNG Club," a luxury boxing gym chain in San Diego; the company filed Chapter 11 bankruptcy in June 2024 and abruptly closed all its remaining locations.

Healthcare
Imperfects, Inc. hero photo
$200K
Imperfects, Inc.
San Diego, CA · Founded 2024

Mindfully Crafted Apparel, Surf Craft and Skateboards for the Human Experience™. Mindful Utility™.

Consumer
Seed$200K
Nobility SD, LLC
San Diego, CA · Founded 2021

Nobility SD, LLC was founded in late 2021 to open a restaurant in La Jolla, San Diego, and later became the subject of a California appellate court case (Nobility SD v. Rocher) stemming from a dispute with the chef who joined the venture in 2022.

SeedConsumer
$178K
M&R Technology, Inc.
San Diego, CA · Founded 2022

M&R Technology, Inc. does business as The Infinity Shield and holds a U.S. patent (invented by Magid Fazel and colleagues) for garage-door safety sensors designed to protect pets and family members from accidental door strikes.

B2B
$170K
Site Bionics, Inc.
San Diego, CA · Founded 2023

Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.

B2B
$150K
MLHere, Inc.
San Diego, CA · Founded 2020
B2B
Pre-Seed$150K
Loupe It LLC
San Diego, CA · Founded 2020

Loupe This offers rare, valuable, and interesting watches that are verified and available to the highest bidder through auctions.

Pre-SeedConsumer
$125K
Wallabi, Inc.
San Diego, CA · Founded 2023

Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

B2B
40acres & a BTC, Inc. hero photo
$119K
40acres & a BTC, Inc.
San Diego, CA · Founded 2025

Financial Freedom with Bitcoin. The digital assets partner for your business. OTC, Swaps, and Enterprise-Grade Solutions

B2B
Alcheme Bio Inc. hero photo
Seed$119K
Alcheme Bio Inc.
San Diego, CA · Founded 2023

Nutralase® is a precision enzyme system from Alcheme Bio that removes off-flavors from plant proteins at the molecular source — clean label, drop-in, no reformulation.

SeedIndustrials
$100K
VALT Investor Group Inc.
San Diego, CA · Founded 2023
Fintech
Seed$100K
RPGMatch Inc.
San Diego, CA · Founded 2023

RPGMatch, a Los Angeles-based tabletop-gaming matchmaking startup, acquired the long-running gaming community site RPGnet in a 2024 merger, with RPGMatch owner Joaquin Lippincott becoming CEO of the combined company.

SeedB2B
$100K
Continuum Holdings, Inc.
San Diego, CA · Founded 2025
Fintech
$97K
Pacific Insurance Network Systems, Inc.
San Diego, CA · Founded 2020
B2B
Cytodyme, Inc. hero photo
Seed$75K
Cytodyme, Inc.
San Diego, CA · Founded 2024

AI-Enabled Quality and Regulatory Workflows

SeedB2B
Gaius Therapeutics, Inc, hero photo
$60K
Gaius Therapeutics, Inc,
San Diego, CA · Founded 2026

Unlocking New Indications for the in vivo CAR-T Modality

Healthcare
$56K
Applied Learning Lab LLC
San Diego, CA · Founded 2025

Applied Learning Lab partners with educators to co-design tailored solutions that enhance teaching and learning in K–12 settings through curriculum and tool evaluation, curriculum design, and professional learning.

B2B
$50K
PAKS LLC
San Diego, CA · Founded 2024

PAKS LLC, operating as PRO-PAKS, specializes in providing customized surgical procedure packs and personalized eye tray systems for the surgical community, particularly in ophthalmology.

Consumer
$50K
Serafin Labs, Inc.
San Diego, CA · Founded 2024

Serafin Labs is a San Diego cancer-therapeutics company founded by CEO Sural Ranamukhaarachchi (UC San Diego bioengineering PhD) and affiliated with UCSD's Fraley Lab; it is still operating in stealth mode.

Healthcare
$45K
Arc Interactive Inc. / DE
San Diego, CA · Founded 2025

Arc Interactive is a digital ideas studio that focuses on brand and digital strategy, product design, web and social content, and app and web development.

B2B
$30K
Greenview Labs, Inc.
San Diego, CA · Founded 2026

According to its founder's LinkedIn profile, Greenview Labs is a golf technology startup founded by Harrison Fitz.

B2B