
San Diego
The breakdown
401 startups on file in San Diego, spanning B2B, Healthcare, Biotechnology, 366 of 401 have disclosed funding, $25.78B combined, 78 at Series A stage, founding dates span 1985-2026.
A bit of history
The city courted the U.S. Navy in the early 1900s, and Naval Base San Diego opened in 1922, planting the military and engineering roots the region still runs on. UC San Diego professor Irwin Jacobs founded Linkabit in 1968 and later Qualcomm in 1985, inventing wireless technology at the heart of 3G and 4G. A few miles away, fellow UCSD professor Ivor Royston launched Hybritech in 1978, the region's first biotech company. San Diego is now one of the world's top biotech clusters.
Startup & tech events in San Diego
Investors headquartered in San Diego
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Double Gold Holdings provides fine beverages from around the world, crafted by artisans and maestros, with a mission to be a first-in-class international adult beverage sales & marketing company that builds premium brands responsibly.
Terafiber was founded by Jim Hanley, a San Diego fiber-infrastructure entrepreneur who had previously founded Netly Fiber, another citywide fiber-network builder, before starting Terafiber in 2023.

Mobile fundraising platform for nonprofits with compliant text messaging, Text-to-Give, and donor engagement. Trusted by 1,000+ organizations.
Alderbuck Energy is modernizing power distribution with solid-state transformer technology built for the electricity demands of AI, EVs, and the modern grid.

Gensee builds practical control infrastructure for AI operating across real developer and production environments by evaluating AI requests, granting narrowly scoped authority, mediating privileged effects, and recording what actually happened.

SmartProperty's Living Reserve Study gives HOA and condo boards real-time reserve fund tracking, capital planning, component inventory, and project management — replacing outdated static reserve studies with a dynamic, always-current platform.

Pi Energy has developed innovative technology that combines standard and novel components to create flexible silicon solar that can be ultra-thin, easily installed on most surfaces, and can capture more energy per day than conventional silicon PV.
LJ Watershed LLC is the legal entity behind "Watershed," the restaurant concept from chef Drew Deckman, per Crunchbase.

Berman Medical is building the image-guided navigation layer for point-of-care procedures to make patient-specific 3D visualization and navigation accessible.

Create engaging, interactive presentations effortlessly with Tiled. Enhance your storytelling and captivate your audience with dynamic, customizable content.

Developing Life-Changing Therapeutics For Our Pets Monoclonal antibodies (mAbs) for modern veterinary practices Developing Life-Changing Therapeutics For Our Pets Monoclonal... Read More
Scout Distribution is a craft alcoholic beverage distributor serving California and Arizona, operating since 2018.
Chefs Life was created in early 2021 by celebrity chef Brian Malarkey (a Top Chef alum and San Diego restaurateur).

Explore Persperion for innovative sweat sensing technology and metabolic health monitoring at your fingertips.
San Diego-based AI-powered polling and community-forum platform for digital publishers, founded by Scott Kaplan, a longtime ESPN 710 LA sports radio host.

Discover the world's most extraordinary collection of perspective-changing rooms, mind-bending installations, and optical illusions.
Perfect offers patented infusion technology that is licensed to manufacturers to lower costs, improve consistency, and scale across markets for infused pre-rolls by breaking down and reconfiguring plant's own chemical compounds.

Our mission is to provide a compassionate, world-class customer experience to the families we serve.
Blending a Japanese style whisky that harmonizes Japanese nature and artisanship

SuperMem GrowthOS pairs AI speed with human judgment to provide growth solutions, with real operators closing what AI cannot.
SWASTHAM TRUST supports needful patients by offering diverse medical services, including providing financial aid for cancer treatment and organizing free health check-up camps.

We believe that everyone - including those with sensitivities and allergies - should be able to enjoy fragrance. Our non-toxic fragrances are formulated to be free of all 82 EU fragrance allergens and top 9 food allergens, on top of being free from hormone disruptors and carcinogens.

Unlocking the microbiome for better skin health The Human Body Relies On The Microbiome For: Inflammation Control Infection Protection Wound Healing And More The Microbiome Cannot Be Ignored For over 100 years, "skincare" has often treated

Aurella is a tax preparation engine designed to eliminate manual data entry by automating the journey from client document intake to return-ready output for tax firms.
Healthy Crops is an international research project that aims to achieve significant yield increases for small-scale producers in Africa and Asia by providing disease-resistant rice varieties.

UFLO1, INC. provides an AI-powered learning platform called Uflo that offers tools and services for students, teachers, and institutions to build personalized courses, share content, assess knowledge, and analyze data to tailor instruction.
Operated as "The BXNG Club," a luxury boxing gym chain in San Diego; the company filed Chapter 11 bankruptcy in June 2024 and abruptly closed all its remaining locations.

Mindfully Crafted Apparel, Surf Craft and Skateboards for the Human Experience™. Mindful Utility™.
Nobility SD, LLC was founded in late 2021 to open a restaurant in La Jolla, San Diego, and later became the subject of a California appellate court case (Nobility SD v. Rocher) stemming from a dispute with the chef who joined the venture in 2022.
M&R Technology, Inc. does business as The Infinity Shield and holds a U.S. patent (invented by Magid Fazel and colleagues) for garage-door safety sensors designed to protect pets and family members from accidental door strikes.
Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.
Loupe This offers rare, valuable, and interesting watches that are verified and available to the highest bidder through auctions.
Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

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Nutralase® is a precision enzyme system from Alcheme Bio that removes off-flavors from plant proteins at the molecular source — clean label, drop-in, no reformulation.
RPGMatch, a Los Angeles-based tabletop-gaming matchmaking startup, acquired the long-running gaming community site RPGnet in a 2024 merger, with RPGMatch owner Joaquin Lippincott becoming CEO of the combined company.

AI-Enabled Quality and Regulatory Workflows

Unlocking New Indications for the in vivo CAR-T Modality
Applied Learning Lab partners with educators to co-design tailored solutions that enhance teaching and learning in K–12 settings through curriculum and tool evaluation, curriculum design, and professional learning.
PAKS LLC, operating as PRO-PAKS, specializes in providing customized surgical procedure packs and personalized eye tray systems for the surgical community, particularly in ophthalmology.
Serafin Labs is a San Diego cancer-therapeutics company founded by CEO Sural Ranamukhaarachchi (UC San Diego bioengineering PhD) and affiliated with UCSD's Fraley Lab; it is still operating in stealth mode.
Arc Interactive is a digital ideas studio that focuses on brand and digital strategy, product design, web and social content, and app and web development.
According to its founder's LinkedIn profile, Greenview Labs is a golf technology startup founded by Harrison Fitz.