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FROM NAVY BASE TO WIRELESS PIONEER AND BIOTECH HUB

San Diego

401
companies
$25.78B
total raised
B2B, Healthcare, Biotechnology
top industries
Photo: Jon Sullivan · Public domain

The breakdown

401 startups on file in San Diego, spanning B2B, Healthcare, Biotechnology, 366 of 401 have disclosed funding, $25.78B combined, 78 at Series A stage, founding dates span 1985-2026.

A bit of history

The city courted the U.S. Navy in the early 1900s, and Naval Base San Diego opened in 1922, planting the military and engineering roots the region still runs on. UC San Diego professor Irwin Jacobs founded Linkabit in 1968 and later Qualcomm in 1985, inventing wireless technology at the heart of 3G and 4G. A few miles away, fellow UCSD professor Ivor Royston launched Hybritech in 1978, the region's first biotech company. San Diego is now one of the world's top biotech clusters.

Startup & tech events in San Diego

Investors headquartered in San Diego

FusionX VenturesEarly-stage
TVC CapitalGrowth Equity
Qualcomm VenturesSeed through growth (primarily Series A and Series B)
S32Early to growth-stage
Intrigue Health, Inc. hero photo
$25K
Intrigue Health, Inc.
San Diego, CA

Intrigue Health aims to empower patients and healthcare providers with home diagnostics.

Healthcare
$25K
Peak Summit Innovations
San Diego, CA · Founded 2025
B2B
$25K
Safu Sake Co
San Diego, CA · Founded 2020

Founded by Wharton MBA Paul Dohrenwend; its premium sake made its retail debut at a Costco in San Diego.

B2B
Craitor, Inc. hero photo
$10K
Craitor, Inc.
San Diego, CA

Craitor builds the production layer for critical hardware, deployed where it is needed, aiming to manufacture sovereignty.

B2B
$6K
MAPLE FUNG MD INC
San Diego, CA · Founded 2025

MAPLE FUNG MD INC provides biotech consulting services, including fractional CMO roles and protocol design, and also offers per diem nephrology care and serves as a clinical trial investigator.

B2B
Influsence, Inc. hero photo
$5K
Influsence, Inc.
San Diego, CA · Founded 2023

Influsence, Inc. provides an AI SaaS platform that offers data insights for influencer marketing to help increase reach, engagement, and revenue for ad agencies and companies.

B2B
$500
Sunflower Psychological Services A Marriage & Family Therapy Corp
San Diego, CA · Founded 2024
B2B
Seasats
San Diego, CA

Seasats offers ocean autonomy solutions designed to deploy in minutes, detect from miles, and react at once, providing high-resolution data for maritime domain awareness, intelligence and surveillance missions, and subsea mapping.

Industrials
Applied Data Finance hero photo
Applied Data Finance
San Diego, CA

Applied Data Finance is a fintech innovator that offers fair and responsible credit access to underestimated U.S. consumers through an AI-powered underwriting and lending platform.

Fintech
Condor Software hero photo
Condor Software
San Diego, CA

Condor is an AI-powered platform that unifies clinical, operational, and financial data into a single source of truth for life sciences companies to manage R&D finances.

B2B
MedicalMex hero photo
MedicalMex
San Diego, CA

MedicalMex helps and protects international patients traveling to Mexico for affordable medical services, including weight loss surgery, plastic surgery, pain management, hair restoration, dental, vascular, more procedures, orthopedic surgery, and general surgery.

Healthcare
National Funding hero photo
National Funding
San Diego, CA

National Funding provides fast small business loans, working capital, term loans, inventory financing, receivables financing, short-term equipment financing, and heavy equipment financing.

Fintech
Emission Free Generators hero photo
Emission Free Generators
San Diego, CA
Industrials
Novoron Bioscience hero photo
Novoron Bioscience
San Diego, CA

Novoron Bioscience is pioneering lipoprotein-receptor drug development to repair damage and degeneration of the brain, spinal cord, and beyond, with therapies to block the spread of prion-like proteins and enhance spinal cord regeneration.

Healthcare
Kenai Therapeutics hero photo
Kenai Therapeutics
San Diego, CA

Kenai Therapeutics is a clinical-stage biotechnology company advancing off-the-shelf dopamine neuron replacement cell therapies and gene-modified medicines to cure neurological conditions.

Healthcare
Neomorph hero photo
Neomorph
San Diego, CA

Neomorph develops molecular glue degraders to target and destroy disease-causing proteins by engineering neomorphic protein surfaces.

Healthcare
Sidewinder Therapeutics hero photo
Sidewinder Therapeutics
San Diego, CA

Sidewinder Therapeutics pioneers the next generation of bispecific antibody-drug conjugates (ADCs) to expand the therapeutic window for patients with difficult-to-treat cancers.

Healthcare
Saphlux hero photo
Saphlux
San Diego, CA

Saphlux provides total micro-LED solutions to enable next-generation displays, including AR Micro-LED Displays and Quantum Dot COB Displays.

Industrials
Rybodyn hero photo
Rybodyn
San Diego, CA

RyboDyn is pioneering immunotherapy development by unlocking the dark proteome with its proprietary RyboCypher™ technology to reveal hidden targets and transform biological signals into breakthrough therapies.

Healthcare
Ascent Funding hero photo
Ascent Funding
San Diego, CA

Ascent Funding provides private student loans for college and career education, covering up to 100% of tuition and expenses with competitive rates and no fees.

Fintech
Replicate Bioscience
San Diego, CA

Replicate Bioscience leverages self-replicating RNA (srRNA) vectors to advance treatments across therapeutic areas like infectious disease, oncology, and autoimmune disorders.

Healthcare
Recludix Pharma hero photo
Recludix Pharma
San Diego, CA

Recludix Pharma is developing new oral precision medicines with selective inhibitors to tackle protein targets for people living with inflammatory diseases.

Healthcare
Atomic Insights
San Diego, CA

Atomic Insights provides payment workflow automation for RIAs and Family Offices, making money movement easy and compliant for wealth managers, client service, and operations teams.

Fintech
Primmune Therapeutics
San Diego, CA

Primmune Therapeutics is a clinical-stage biotechnology company focused on developing systemic cancer immunotherapies that activate the immune system in a precise and controlled manner.

Healthcare
Sharpen DTX hero photo
Sharpen DTX
San Diego, CA

Sharpen DTX, by Resiliency Technologies, Inc., provides mental health literacy tools and prevention toolkits for schools, families, colleges, and community organizations to improve mental wellness and resiliency.

Healthcare
Plura (formerly Bloom Community)
San Diego, CA · Founded 2020 · 5 employees

The social app for edge-of-culture communities

Y CombinatorConsumer
Zephyr Fusion hero photo
Zephyr Fusion
San Diego, CA · Founded 2025 · 2 employees

Powering tomorrow's industrial revolution in space

Y CombinatorIndustrials
Rethoric hero photo
Rethoric
San Diego, CA · Founded 2021 · 4 employees

LinkedIn content consultancy and scheduling platform for busy founders

Y CombinatorB2B
Forage hero photo
Forage
San Diego, CA · Founded 2021 · 66 employees

Payments infrastructure for government benefits

Y CombinatorFintech
Origami Therapeutics, Inc.
San Diego, CA · Founded 2022 · 4 employees

Oral drugs to halt neurodegeneration

Y CombinatorHealthcare
Persephone Biosciences
San Diego, CA · Founded 2017 · 6 employees

We are using the gut microbiome to end cancer.

Y CombinatorHealthcare
CB Therapeutics hero photo
CB Therapeutics
San Diego, CA · Founded 2018 · 18 employees

Fermentation-derived natural products to solve health problems

Y CombinatorHealthcare
Trestle Biotherapeutics hero photo
Trestle Biotherapeutics
San Diego, CA · Founded 2021 · 2 employees

Bioengineered kidneys for patients with kidney failure

Y CombinatorHealthcare
Cisterna Biologics
San Diego, CA · Founded 2022 · 2 employees

High quality mRNA for therapeutic application

Y CombinatorHealthcare
Elythea hero photo
Elythea
San Diego, CA · Founded 2023 · 2 employees

ML to predict and prevent pregnancy complications

Y CombinatorHealthcare
Sourcify hero photo
Sourcify
San Diego, CA · Founded 2017 · 15 employees

Sourcify helps brands manufacture products in Asia.

Y CombinatorB2B
MedCrypt
San Diego, CA · Founded 2018 · 16 employees

MedCrypt gives medical device vendors cybersecurity features in a few…

Y CombinatorHealthcare
Integrated Reasoning hero photo
Integrated Reasoning
San Diego, CA · Founded 2022 · 1 employees

Faster processors for solving NP-complete problems

Y CombinatorB2B
ZeroSettle hero photo
ZeroSettle
San Diego, CA · Founded 2026 · 2 employees

Drop-in Direct Billing SDK for In-App Purchases

Y CombinatorFintech
Recover hero photo
Recover
San Diego, CA · Founded 2021 · 10 employees

Government-funded online addiction treatment

Y CombinatorHealthcare
VedaBio hero photo
VedaBio
San Diego, CA · Founded 2021 · 30 employees

CRISPR powered Diagnostics with results in minutes.

Y CombinatorHealthcare