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Aerial view looking east toward Santa Ana and Irvine, California
UC IRVINE RESEARCH SPINOUTS AND ORANGE COUNTY'S TECH CORRIDOR

Irvine

231
companies
$8.03B
total raised
B2B, Healthcare, Technology
top industries
Photo: Joe Mabel · CC BY-SA 4.0

The breakdown

231 startups on file in Irvine, spanning B2B, Healthcare, Technology, 215 of 231 have disclosed funding, $8.03B combined, 42 at Series A stage, founding dates span 1985-2026.

A bit of history

UC Irvine opened in 1965 as the intellectual anchor of a master-planned city built by the Irvine Company, and its research park became the seed for what's now called the Tech Coast. Three UCLA graduates started Silicon & Synapse out of a business park near campus in February 1991, working with about $10,000 each; it later became Blizzard Entertainment. Irvine's tech and biotech base has kept growing from there, anchored today by companies like Broadcom.

Investors headquartered in Irvine

Pismo VenturesPre-Seed, Seed, Series A
TCA Venture GroupSeed, Bridge, Early Series A
Sunstone ManagementPre-Seed, Seed
Series D$10.0M
Water Health International
Irvine, CA · Founded 2006 · 751 employees

Water Health International is a company founded in 2006.

Series DCleantech & Climate
$65.3M
Axiom Microdevices
Irvine, CA · Founded 2002 · 5 employees

Axiom Microdevices is an Irvine; California-based semiconductor company founded in 2002.

Semiconductor
$18.2M
Kofax
Irvine, CA · Founded 1985 · 1381 employees

Kofax is a robotic process automation company that digitizes complex and information-intensive workflows.

Enterprise Software
Series B$23.0M
Ridemakerz
Irvine, CA · Founded 2006 · 351 employees

Ridemakerz is an Irvine; California-based company founded in 2006.

Series BRetail
Series E$30.0M
TherOx
Irvine, CA · Founded 1995 · 31 employees

TherOx is an Irvine; California-based company founded in 1995.

Series EMedical device
$683.9M
Adamantium Capital LLC
Irvine, CA · Founded 2023
Industrials
$164.4M
CBC Bancorp
Irvine, CA
Fintech
ModRetro, Inc. hero photo
Series F$164.3M
ModRetro, Inc.
Irvine, CA · Founded 2023

ModRetro brings the best of the past to modern consumer electronics, for those who crave technology with a human soul.

Series FB2B
$123.1M
Bright Uro, Inc.
Irvine, CA · Founded 2021
Healthcare
Series C$100.4M
JenaValve Technology Inc
Irvine, CA

JenaValve Technology Inc. offers the Trilogy Transcatheter Heart Valve, which is an FDA-approved TAVR system specifically designed for aortic regurgitation, utilizing locator technology for alignment and secure anchoring.

Series CHealthcare
PatientFi, Inc. hero photo
Series B$96.9M
PatientFi, Inc.
Irvine, CA

PatientFi, Inc. provides monthly payment plans to help patients break cost barriers for procedures in areas such as plastic surgery, medspa & dermatology, fertility, hair restoration, audiology, cosmetic dental, and vision.

Series BB2B
Series B$90.0M
VERTIMASS, LLC
Irvine, CA

Vertimass seeks to develop and widely license breakthrough technologies that convert renewable ethanol into hydrocarbons to expand the use of sustainable transportation fuels.

Series BB2B
$57.8M
Wilshire Finance Partners, Inc.
Irvine, CA
Fintech
$50.0M
AVAYNE LLC
Irvine, CA · Founded 2020

EVH manages government contracts from award to completion by coordinating qualified subcontractors, ensuring compliance, and keeping performance on track.

Industrials
$47.8M
Oncocyte Corp
Irvine, CA

Oncocyte is a publicly traded diagnostics company (Nasdaq: OCX) that later renamed itself Insight Molecular Diagnostics and relocated its headquarters to Nashville.

Healthcare
$42.0M
Restora Medical, Inc.
Irvine, CA · Founded 2023

Restora Medical, Inc. focuses on Restorative Sleep Apnea Therapy using Targeted Nerve Stimulation.

Healthcare
Series C$41.2M
Movandi Corp
Irvine, CA

Movandi Corp develops next-generation mmWave solutions that power both terrestrial and non-terrestrial communications, advancing 5G, fixed wireless, and satellite networks worldwide.

Series CB2B
$34.6M
Vital Capital Medical - Temple TX DST
Irvine, CA · Founded 2026
B2B
Smart Health Diagnostics Co hero photo
Series B$27.5M
Smart Health Diagnostics Co
Irvine, CA

SmartHealth Holdings, Inc. drives transformative innovation in healthcare diagnostics, including groundbreaking imaging systems for pathology, advanced vascular diagnostics, and oncology-focused solutions, notably with its pioneering MUSE technology for slide-free digital pathology.

Series BHealthcare
$26.9M
GATC HEALTH CORP
Irvine, CA · Founded 2020

GATC Health is a tech-bio company that uses proprietary AI to accelerate and de-risk the discovery and development of safer and more effective drugs for biopharma companies and investors.

B2B
$25.0M
NANO FINANCIAL HOLDINGS, INC.
Irvine, CA
Fintech
Innova Vascular, Inc. hero photo
Series A$21.9M
Innova Vascular, Inc.
Irvine, CA

Innova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.

Series AB2B
$20.0M
PDS Equities, LLC
Irvine, CA · Founded 2021
B2B
Series B$16.4M
Mixed-Signal Devices Inc.
Irvine, CA

Mixed-Signal Devices Inc. delivers multi-gigahertz digital timing solutions with ultra-low jitter, stability, and programmability for AI infrastructure, 5G networks, and high-performance automotive platforms.

Series BB2B
Huupe Inc. hero photo
Series A$15.6M
Huupe Inc.
Irvine, CA · Founded 2020

huupe brings you the world’s first smart basketball hoop, providing NBA level workouts, on-demand training, live coaching, data tracking and more.

Series AB2B
SWARM Engineering, Inc. hero photo
Series A$15.0M
SWARM Engineering, Inc.
Irvine, CA

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.

Series AB2B
$13.1M
Evergreen Partners Holdco, Inc.
Irvine, CA · Founded 2024
B2B
Series B$11.6M
THERAHEART INC.
Irvine, CA · Founded 2023

Theraheart Inc. is a medical device manufacturer dedicated to providing innovative, minimally invasive solutions aimed at improving the lives of Heart Failure patients.

Series BB2B
Turion Space Corp. hero photo
Series B$11.1M
Turion Space Corp.
Irvine, CA · Founded 2020

Accelerating humanity’s galactic destiny

Series BB2B
Series A$10.3M
Orbee, Inc.
Irvine, CA · ~11-50 employees

Orbee is the automotive data platform that unifies every customer signal so dealerships can activate smarter audiences, run better campaigns, and close more deals.

Series AB2B
Highlight Holding Inc. hero photo
Series B$10.1M
Highlight Holding Inc.
Irvine, CA · Founded 2024

The collective brain for high-velocity teams. Join waitlist: highlightai.com

Series BB2B
Permissionless Labs, Inc. hero photo
Series A$9.2M
Permissionless Labs, Inc.
Irvine, CA · Founded 2021 · ~11-50 employees

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.

Series AB2B
Series A$8.2M
4600 NVDT LLC
Irvine, CA · Founded 2025
Series AB2B
$8.2M
CU DIRECT CORP
Irvine, CA · ~501-1,000 employees

CU Direct Corp, founded in 1994 and now branded as Origence, is a credit union service organization (CUSO) collectively owned by 124 credit union shareholders rather than by venture investors.

B2B
CELESTIAL THERAPEUTICS INC. hero photo
Seed$7.9M
CELESTIAL THERAPEUTICS INC.
Irvine, CA · Founded 2019

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.

SeedHealthcare
Tally Surgical, Inc. hero photo
Seed$7.2M
Tally Surgical, Inc.
Irvine, CA · Founded 2020

The Tally Surgical retained sponge prevention solution utilizes UHF RFID to simplify and speed an accurate count of surgical sponges and towels.

SeedHealthcare
$6.7M
Autopilot Holdings Corp
Irvine, CA · Founded 2020

Autopilot was built by the team behind the viral 'Pelosi Tracker' and lets users copy politicians' and top traders' stock trades; co-founder Brian Schardt has said the app manages roughly $1.8B in tracked assets.

B2B
Series A$6.6M
Petalfast Inc.
Irvine, CA · Founded 2020

Petalfast Inc. equips cannabis brands for sustainable success through sales and distribution, integrated sales planning, and infrastructure.

Series AB2B
$6.5M
HighTechLending Inc.
Irvine, CA
Fintech
$5.7M
IRA Sunshine Holdings, LLC
Irvine, CA · Founded 2026
B2B
Boundless Devices, Inc. hero photo
Seed$5.6M
Boundless Devices, Inc.
Irvine, CA · Founded 2025

We partner with global industry leaders to craft and deliver groundbreaking consumer electronics and connected solutions.

SeedB2B
Series A$5.5M
Truvion Holdings
Irvine, CA · Founded 2023
Series AB2B
$5.4M
Core-Arms, LLC
Irvine, CA

A federally licensed (ATF FFL) firearms manufacturer/dealer based in Irvine, CA, with patents assigned to inventor David Roth.

Industrials
New Range Financial Intelligence, Inc. hero photo
$5.4M
New Range Financial Intelligence, Inc.
Irvine, CA · Founded 2024

Comprehensive compliance platform for broker-dealers and fintechs. Automate CAT/CAIS reporting, best execution analysis, trade surveillance, corporate actions, and data reconciliation.

B2B
Cochl Inc hero photo
Series B$5.0M
Cochl Inc
Irvine, CA · Founded 2022

Official website of Cochl

Series BB2B
$5.0M
FRDM Collective LLC
Irvine, CA · Founded 2025

Co-founded and led by CEO Isaac Oswalt; it is a private-equity roll-up platform that acquires and consolidates short-term rental operators while letting the original operators retain equity.

B2B
Series B$5.0M
Aten Technology, Inc.
Irvine, CA

ATEN provides solutions across various markets and applications, offering products like KVM switches, professional audio/video equipment, consumer electronics, and USB solutions.

Series BB2B
Toughbuilt Industries, Inc hero photo
$5.0M
Toughbuilt Industries, Inc
Irvine, CA

Professional-Grade Sawhorses, Tool Pouches and Knee Pads for work by ToughBuilt. Strictly for construction workers and electricians who need the best for the job!

B2B
Series A$4.9M
GoVyrl, Inc.
Irvine, CA
Series AB2B
Simply Bread Co. hero photo
Seed$4.6M
Simply Bread Co.
Irvine, CA · Founded 2022

Turn your bread into dough. The Simply Bread Oven and app help bakers at every stage bake more, sell more, and grow a thriving micro-bakery.

SeedB2B
Vesica Health, Inc. hero photo
$4.5M
Vesica Health, Inc.
Irvine, CA · Founded 2022

Vesica Health, Inc. brings clarity to clinical decisions by combining next-generation molecular diagnostics and Blue Light Cystoscopy to improve early detection and diagnosis for bladder cancer patients, and offers the noninvasive urine-based AssureMDx test to identify hematuria patients at increased risk for bladder cancer.

Healthcare
Seed$4.4M
CLEARFLOW, Inc
Irvine, CA · ~11-50 employees

ClearFlow develops medical technologies including PleuraFlow Active Clearance Technology to reduce Retained Blood Syndrome complications and ClearFix Rigid Sternal Fixation for stabilization and fixation of anterior chest wall fractures.

SeedHealthcare
Tenovi Co. hero photo
Series A$4.2M
Tenovi Co.
Irvine, CA · Founded 2021

Tenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.

Series AHealthcare
SocialCrowd, Inc. hero photo
Pre-Seed$4.0M
SocialCrowd, Inc.
Irvine, CA · Founded 2022 · 7 employees

SocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!

Pre-SeedB2B
Laguna Tech USA, Inc. hero photo
Series A$3.3M
Laguna Tech USA, Inc.
Irvine, CA · Founded 2022

Laguna Tech USA is developing the ZETA Transcatheter Aortic Valve System, a balloon-expandable valve solution designed for Aortic Regurgitation and Aortic Stenosis.

Series AHealthcare
Amble Activewear hero photo
Seed$3.2M
Amble Activewear
Irvine, CA · Founded 2021

Shop Amble Clothing — premium coastal golf polos, hoodies, shorts, and active apparel for men. Designed for the course, the coast, and everywhere in between. Free shipping on orders $100+.

SeedConsumer
Toro Neurovascular, Inc. hero photo
Series B$3.0M
Toro Neurovascular, Inc.
Irvine, CA · Founded 2021

Toro Neurovascular develops advanced stroke devices, specifically catheter technology, for the treatment of ischemic stroke.

Series BB2B
Seed$3.0M
AgBlox, Inc.
Irvine, CA · Founded 2019

AgBlox is an AI platform that predicts agricultural commodity prices.

SeedB2B
Telesair, Inc. hero photo
Series A$3.0M
Telesair, Inc.
Irvine, CA

Telesair, Inc. is a non-invasive ventilation manufacturer. We enable respiratory care in any setting through high-flow oxygen generation and portability.

Series AB2B
Series A$2.7M
Impossible Kicks Holding Company, Inc.
Irvine, CA · Founded 2022

Founded in 2021 by sneaker reseller Wayne Mocadlo with his brother John Mocadlo as COO, Impossible Kicks grew into one of the largest sneaker and streetwear resale chains in the US and has raised funds via equity crowdfunding.

Series AConsumer