
Irvine
The breakdown
231 startups on file in Irvine, spanning B2B, Healthcare, Technology, 215 of 231 have disclosed funding, $8.03B combined, 42 at Series A stage, founding dates span 1985-2026.
A bit of history
UC Irvine opened in 1965 as the intellectual anchor of a master-planned city built by the Irvine Company, and its research park became the seed for what's now called the Tech Coast. Three UCLA graduates started Silicon & Synapse out of a business park near campus in February 1991, working with about $10,000 each; it later became Blizzard Entertainment. Irvine's tech and biotech base has kept growing from there, anchored today by companies like Broadcom.
Startup & tech events in Irvine
Investors headquartered in Irvine
Water Health International is a company founded in 2006.
Axiom Microdevices is an Irvine; California-based semiconductor company founded in 2002.
Kofax is a robotic process automation company that digitizes complex and information-intensive workflows.
Ridemakerz is an Irvine; California-based company founded in 2006.
TherOx is an Irvine; California-based company founded in 1995.

ModRetro brings the best of the past to modern consumer electronics, for those who crave technology with a human soul.
JenaValve Technology Inc. offers the Trilogy Transcatheter Heart Valve, which is an FDA-approved TAVR system specifically designed for aortic regurgitation, utilizing locator technology for alignment and secure anchoring.

PatientFi, Inc. provides monthly payment plans to help patients break cost barriers for procedures in areas such as plastic surgery, medspa & dermatology, fertility, hair restoration, audiology, cosmetic dental, and vision.
Vertimass seeks to develop and widely license breakthrough technologies that convert renewable ethanol into hydrocarbons to expand the use of sustainable transportation fuels.
EVH manages government contracts from award to completion by coordinating qualified subcontractors, ensuring compliance, and keeping performance on track.
Oncocyte is a publicly traded diagnostics company (Nasdaq: OCX) that later renamed itself Insight Molecular Diagnostics and relocated its headquarters to Nashville.
Restora Medical, Inc. focuses on Restorative Sleep Apnea Therapy using Targeted Nerve Stimulation.
Movandi Corp develops next-generation mmWave solutions that power both terrestrial and non-terrestrial communications, advancing 5G, fixed wireless, and satellite networks worldwide.

SmartHealth Holdings, Inc. drives transformative innovation in healthcare diagnostics, including groundbreaking imaging systems for pathology, advanced vascular diagnostics, and oncology-focused solutions, notably with its pioneering MUSE technology for slide-free digital pathology.
GATC Health is a tech-bio company that uses proprietary AI to accelerate and de-risk the discovery and development of safer and more effective drugs for biopharma companies and investors.
Innova is engaged in developing innovative medical devices for treating vascular disease using a minimally invasive approach. Contact us.
Mixed-Signal Devices Inc. delivers multi-gigahertz digital timing solutions with ultra-low jitter, stability, and programmability for AI infrastructure, 5G networks, and high-performance automotive platforms.

huupe brings you the world’s first smart basketball hoop, providing NBA level workouts, on-demand training, live coaching, data tracking and more.

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.
Theraheart Inc. is a medical device manufacturer dedicated to providing innovative, minimally invasive solutions aimed at improving the lives of Heart Failure patients.

Accelerating humanity’s galactic destiny
Orbee is the automotive data platform that unifies every customer signal so dealerships can activate smarter audiences, run better campaigns, and close more deals.

The collective brain for high-velocity teams. Join waitlist: highlightai.com

Permissionless Labs is an AI lab providing high-throughput inference, durable model storage, and custom fine-tuning — frontier infrastructure you can access without gatekeepers or lock-in.
CU Direct Corp, founded in 1994 and now branded as Origence, is a credit union service organization (CUSO) collectively owned by 124 credit union shareholders rather than by venture investors.

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.

The Tally Surgical retained sponge prevention solution utilizes UHF RFID to simplify and speed an accurate count of surgical sponges and towels.
Autopilot was built by the team behind the viral 'Pelosi Tracker' and lets users copy politicians' and top traders' stock trades; co-founder Brian Schardt has said the app manages roughly $1.8B in tracked assets.
Petalfast Inc. equips cannabis brands for sustainable success through sales and distribution, integrated sales planning, and infrastructure.

We partner with global industry leaders to craft and deliver groundbreaking consumer electronics and connected solutions.
A federally licensed (ATF FFL) firearms manufacturer/dealer based in Irvine, CA, with patents assigned to inventor David Roth.

Comprehensive compliance platform for broker-dealers and fintechs. Automate CAT/CAIS reporting, best execution analysis, trade surveillance, corporate actions, and data reconciliation.

Official website of Cochl
Co-founded and led by CEO Isaac Oswalt; it is a private-equity roll-up platform that acquires and consolidates short-term rental operators while letting the original operators retain equity.
ATEN provides solutions across various markets and applications, offering products like KVM switches, professional audio/video equipment, consumer electronics, and USB solutions.
Professional-Grade Sawhorses, Tool Pouches and Knee Pads for work by ToughBuilt. Strictly for construction workers and electricians who need the best for the job!

Turn your bread into dough. The Simply Bread Oven and app help bakers at every stage bake more, sell more, and grow a thriving micro-bakery.

Vesica Health, Inc. brings clarity to clinical decisions by combining next-generation molecular diagnostics and Blue Light Cystoscopy to improve early detection and diagnosis for bladder cancer patients, and offers the noninvasive urine-based AssureMDx test to identify hematuria patients at increased risk for bladder cancer.
ClearFlow develops medical technologies including PleuraFlow Active Clearance Technology to reduce Retained Blood Syndrome complications and ClearFix Rigid Sternal Fixation for stabilization and fixation of anterior chest wall fractures.

Tenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.

SocialCrowd automatically tracks employee progress towards goals, reminds them of the work they have left, and rewards them instantly – so you can save time and stay focused!

Laguna Tech USA is developing the ZETA Transcatheter Aortic Valve System, a balloon-expandable valve solution designed for Aortic Regurgitation and Aortic Stenosis.

Shop Amble Clothing — premium coastal golf polos, hoodies, shorts, and active apparel for men. Designed for the course, the coast, and everywhere in between. Free shipping on orders $100+.

Toro Neurovascular develops advanced stroke devices, specifically catheter technology, for the treatment of ischemic stroke.
AgBlox is an AI platform that predicts agricultural commodity prices.

Telesair, Inc. is a non-invasive ventilation manufacturer. We enable respiratory care in any setting through high-flow oxygen generation and portability.
Founded in 2021 by sneaker reseller Wayne Mocadlo with his brother John Mocadlo as COO, Impossible Kicks grew into one of the largest sneaker and streetwear resale chains in the US and has raised funds via equity crowdfunding.