
Irvine
The breakdown
231 startups on file in Irvine, spanning B2B, Healthcare, Technology, 215 of 231 have disclosed funding, $8.03B combined, 42 at Series A stage, founding dates span 1985-2026.
A bit of history
UC Irvine opened in 1965 as the intellectual anchor of a master-planned city built by the Irvine Company, and its research park became the seed for what's now called the Tech Coast. Three UCLA graduates started Silicon & Synapse out of a business park near campus in February 1991, working with about $10,000 each; it later became Blizzard Entertainment. Irvine's tech and biotech base has kept growing from there, anchored today by companies like Broadcom.
Startup & tech events in Irvine
Investors headquartered in Irvine

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Sensible Care Inc. offers online therapy and psychiatry for individuals, couples, and families, including adults, teens, and children, with access to in-network care.

Empowering Indie Artists to Connect, Grow, and Earn - OpenWav
ZUUM Transportation is a logistics technology company that develops a comprehensive logistics platform including ZUUM Automated Broker for freight brokers to digitize operations and ZUUM BEYOND TMS for shippers.

Bedrock Servicing provides a hybrid operating model for private credit lenders. We combine institutional-grade loan servicing with proprietary technology to automate complex asset management, ensure audit-readiness, and eliminate administrative friction.
Discover Allevion Therapeutics’ Allevx™ Smart-Band, a wearable device designed to reduce movement-related disorders due to Essential Tremor.

AI-powered travel technology SaaS platform offering end-to-end solutions for Corporates, B2B, and B2C.
XOStem Biosciences' listed principals include UC Irvine professor Jonathan Lakey, who co-developed the Edmonton Protocol, the landmark pancreatic islet cell transplantation procedure for treating type 1 diabetes.

Calico Building Services is a leading nationwide provider of commercial janitorial, repair, maintenance and construction services.
Food Safety Systems LLC provides food safety and sanitation resources, compliance, education & training, verification, and technology services primarily for the food services industry in Southern California.

A unified solution to measure risk, reduce downtime, and strengthen insurance outcomes.
Thumb Technologies, an Irvine, CA conversational-analytics startup, was co-founded by Jae Chung (previously at Amazon and Autodesk) and Daniel Kopeinigg.

Bluon provides indispensable technical data and support to the HVAC professional industry via our proprietary database and AI platform to increase productivity and provide a clear competitive advantage for our users and partners.
FiGPiNS are hand-crafted enamel character pins featuring a patented backer that serves as a pin clasp AND display stand! FiGPiN elevates collectible pins!

World Tree grows Paulownia hardwood through regenerative forestry in partnership with farmers across the Americas.

YouAttest offers cloud based identity auditing solutions and management We Securely manage user access and ensure compliance with ease Get started today!

At Dardo Studios, we provide boutique solutions for comprehensive art creation, including concept art, 3D modeling, animation, VFX, and more. We also offer art direction, recruiting services, and expertise in structuring and managing art departments.

Connect your clients to trusted aging care experts quickly and seamlessly with bQuest. Become their go-to lifeline during family crises through our easy, vetted referral platform.

Timecap is a customizable habit tracker application designed to help users build healthy and productive habits.
Uscape Apparel LLC creates localized lifestyle apparel for collegiate, destination, and custom markets.
Squeeze Software, Inc. provides forward-thinking IT for businesses.
ONIT Sciences, based in Irvine, brought on Eric Mathur, a globally recognized plant geneticist and molecular biologist, as its Chief Science Officer.

Facility Management Software designed to help businesses save time and money while providing real-time, actionable data.

Vincit is a Nordic digital business partner focusing on commercial solutions, enterprise platforms, and data & AI. We turn digital into business results by combining leading platforms and tailored solutions.

Essential HR Services is a team of experienced, professional Human Resources (HR) Consultants specializing in Labor Law Compliance, Employee Relations, HR Administration, Organizational Development, Training, Health and Wellness Programs, and Payroll. Our goal is to deliver quality service, with the utmost integrity.
Olobby is an all-in-one app for work that provides tasks, files, communication, and more, with both desktop and cloud solutions.
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Scientia Capital Management empowers retail investors with AI-powered investing, wealth management, and investment analysis. Smarter, risk-aware strategies for confident growth.

Brands is focused on building our own portfolio—brands that align consumer desire with long-term health and wellness trends.

AccessStar empowers independent and meaningful lives for people with intellectual or developmental disabilities by providing various behavioral and developmental services such as group homes, community engagement, and nursing care.
Phythera Therapeutics, Inc. is a biotechnology company leveraging the power of natural compounds to modulate key biological pathways in cancer and tissue regeneration to improve human health.
KanDo is an AI-powered knowledge and process management tool for creating and managing AI-assisted Standard Operating Procedures, with enterprise-grade multi-tenant authentication and an intelligent knowledge base.
JouraBooks is desktop-native accounting software for teams migrating off QuickBooks Desktop, offering a practical QBD import path, local-first data control on your own machine, and an AI assistant (Ask Joura) for accounting and back-office work. Currently in private beta.
Toshiba America Electronic Components is the North American electronic components arm of Toshiba; established in 1989.
Ambros Therapeutics is a clinical-stage biotechnology company focused on developing innovative and transformative medicines for diseases with a high unmet medical need, with its lead investigational program targeting complex regional pain syndrome type 1 (CRPS-1).
Anchr provides AI agents for physical operations in industries such as food distribution, industrial and MRO, healthcare and pharma, building and technical supplies, and consumer packaged goods.
Synergetics.AI offers a trusted agentic infrastructure platform that allows AI agents to identify, communicate, and transact securely across enterprise boundaries.
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Boumarang builds hydrogen-powered, AI-enabled unmanned systems for air and maritime operations. Long endurance. Domestic IP. Dual-use by design.

Eagle Mountain Data provides next-generation infrastructure, including GPU services, storage, and networking, designed for complex AI workloads and real-time responsiveness at the edge.

Creating a New Class of Drugs to Address Incurable Autoimmune Diseases

The AI-native agency

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