Medical Technology startups in Southern California

Founded by physician-entrepreneur Remo Moomiaie-Qajar, M.D.; the San Diego biotech has raised $14.4M in funding, including from Partners Investment.

Theraheart Inc. is a medical device manufacturer dedicated to providing innovative, minimally invasive solutions aimed at improving the lives of Heart Failure patients.

Syrna Therapeutics is pioneering a new class of mRNA targeting therapeutics that stop expression of disease-causing proteins

RCE Technologies is developing Infrasensor™, a non-invasive wearable that uses infrared spectroscopy and machine learning to detect severe coronary artery occlusion in about three minutes, without a blood draw — aimed at catching the 60%+ of heart attacks that standard chest-pain triage misses.

Founded by entrepreneurs Simon Arkell and Alex Dickinson with seed funding from AIX Ventures and Page One Ventures; the company later rebranded as Ryght.

Cooler Heads is the creator of Amma™, an FDA-cleared scalp cooling system that helps cancer patients reduce hair loss during chemotherapy. Amma delivers hospital-grade cold-cap therapy that’s simple, portable, and patient-first.

Digital Surgery Systems, Inc. is the legal name behind True Digital Surgery, a Goleta, CA maker of 3D robotic-assisted surgical microscopy systems that was fully acquired by German medical device company B. Braun SE in September 2025.

AeroRx Therapeutics is developing potential best-in-class nebulized combination therapies to improve COPD treatment.

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We bring cell therapies to patients through innovative point-of-care manufacturing solutions.

Learn how Genomic Life enhances health and well-being through genetic screenings, early detection, personalized cancer navigation, and ongoing support. Optimize employee benefits and create a healthier workforce.

EGB Ventures is a physician-led venture formation family office focused on creating, financing, and developing biotechnology companies built around clinically validated therapeutic opportunities.

Avicena, LLC develops microLED-based optical interconnects for high-speed communications, enabling energy-efficient AI data centers and GPU clusters to scale up.

Topicals is transforming the way you feel about skin through effective science backed products for chronic skin conditions and mental health advocacy.

Provisio Medical Technologies Corp. is dedicated to developing innovative solutions for Peripheral Artery Disease, including an automated, integrated smart-catheter technology called the SLT Platform which includes the SLT FLOW, the world's first and only catheter-based volumetric blood flow measurement intra-procedurally.

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Luxury haircare and tools that turn everyday routines into meaningful rituals, helping support healthier hair with ease and intention.

DermOQ was founded by Bradley Patt, who previously served as CEO of medical imaging company Gamma Medica.

MSI is the single platform for medical device cybersecurity compliance — tools, data, and expert support to meet FDA requirements and ship on schedule. 100% FDA approval rate.

SLAM BioTherapeutics, Inc. is a biotech company developing first-in-class human antibody-drug conjugates (ADCs) and bispecific monoclonal antibodies targeting blood cancers.

Bringing Confidence to your Prostate Cancer Treatment Decisions A revolutionary platform that delivers tailored insights for prostate cancer management,

Celestial Therapeutics is developing novel therapies based on innovative and groundbreaking science to treat, prevent and cure infectious diseases, rare diseases and cancers.

EliseAI is the industry-leading AI platform transforming both property management and healthcare through automation and conversational AI that help housing and healthcare organizations streamline communications and improve operational efficiency.

EpiPlex™ assay detects RNA modifications by proximity barcoding and short read RNA sequencing, revealing insights into gene regulation for disease research.

We are a pioneering biotechnology company dedicated to producing innovative solutions to treat traumatic nerve injury.

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BioProtonics is a pioneering company focused on advancing diagnostic imaging through its Magnetic Resonance Histopathology (MRH) technology. MRH offers a non-invasive, high-resolution method for analyzing tissue microarchitecture during routine MRI scans. MRH

The Tally Surgical retained sponge prevention solution utilizes UHF RFID to simplify and speed an accurate count of surgical sponges and towels.

Tele911 integrates emergency medicine telehealth and patient navigation into 911 & EMS systems.

Cellibre, Inc. uses biology as a manufacturing technology, leveraging nature to create sustainable products through strain engineering, biochemistry, and precision fermentation.

Qureator provides integrated human disease model and AI platform to evaluate treatment efficacy in complex disease models.

Independa Health Hub® is a simple to use ecosystem of health & wellness benefits on any screen — TV, tablet, computer, or phone. Many benefits absolutely FREE!

Developing novel long-acting therapeutics targeting chronic cardiometabolic diseases.

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EyeArt by Eyenuk is an autonomous, FDA-cleared AI for diabetic retinopathy screening and disease detection at the point of care.

selectION Therapeutics' si-544 is a first-in-class Kv1.3 blocker and the first disease modifying treatment for T cell autoimmunity. Autoimmunity affects millions worldwide, but current treatments leave the root cause untouched. si-544 is the first therapy to safely and selectively deactivate disease-causing T cells, while preserving immune competence.

Ospitek empowers surgical centers with real-time IoT and AI-enhanced solutions, improving workflow efficiency, patient care, and staff coordination. Seamlessly integrate with legacy systems and unlock unparalleled operational visibility with Ospitek’s cutting-edge platform.

BURL Concepts provides innovative ultrasound solutions to instantly access brain performance and guide clinical interventions.

RLTY LLC empowers real estate professionals nationwide with services and support, including commission funding, LLC setup assistance, tax preparation and bookkeeping services, and healthcare coverage options.

Preventive health platform for dogs. AI Health Companion, at-home blood draws & 40+ biomarker panel. Vet-built care plans for early disease detection.

Founded and led by Dr. Sheila Gujrathi, a physician-scientist and serial biotech executive who also founded/chairs Vidya Therapeutics and Lila Biologics and sits on the board of Janux Therapeutics; the company is based in Encinitas, CA.

AcuraStem is a patient-based biotechnology company pioneering how treatments are developed for neurodegenerative diseases, including sporadic ALS and FTD, using its proprietary disease-modeling platform, iNeuroRx®.

Excellos Labs is a cell therapy CDMO offering apheresis collection, PBMC and leukopak processing, T/NK cell isolation, and cGMP manufacturing for biotech and pharma.

California Compounding is a trusted compounding partner for telehealth and clinics, offering office stock programs, prescriber portals, and scalable fulfillment.

Transposon Therapeutics, Inc. is developing TPN-101 (also known as Censavudine) and other LINE-1 reverse transcriptase inhibitors for the treatment of rare neurodegenerative diseases such as progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD).

XiltriX provides 24/7 live agent monitoring for biotech and biopharma labs and facilities that need to prevent sample loss and maintain compliance.

Resolute Science, Inc. is a biotechnology company developing a pipeline of first-in-class synthetic drug conjugates, specifically Macrophage-Targeted Conjugates (MAC-TACs), for the treatment of solid tumors.

Founded in 2016 by CEO Matt Lashey, who created the chemoWave cancer-treatment tracking app; investors include Plug and Play Tech Center.

Nasdaq-listed (QLGN); received a $41 million strategic PIPE investment from Faraday Future, whose founder is Chinese entrepreneur YT Jia (Jia Yueting).

Vesica Health, Inc. brings clarity to clinical decisions by combining next-generation molecular diagnostics and Blue Light Cystoscopy to improve early detection and diagnosis for bladder cancer patients, and offers the noninvasive urine-based AssureMDx test to identify hematuria patients at increased risk for bladder cancer.

ClearFlow develops medical technologies including PleuraFlow Active Clearance Technology to reduce Retained Blood Syndrome complications and ClearFix Rigid Sternal Fixation for stabilization and fixation of anterior chest wall fractures.

NeuraNova's mission is to revolutionize neurovascular diagnostics to respond rapidly to critical moments.

AI-driven medical coding from Synaptec Health - a more accurate, secure, and comprehensive solution for all your medical coding needs.

Tenovi remote patient monitoring 40+ FDA-cleared hardware devices power RPM and RTM programs with the first plug-and-play Cellular Gateway.

Founded in 2018 by Dr. Virender K. Sharma, a serial medtech entrepreneur and former Mayo Clinic professor, alongside CEO Dr. Holger Friedrich; the company develops single-shot catheter ablation technology for atrial fibrillation.