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Biotechnology & Life Sciences startups in Southern California

The life-science research base behind San Diego's and Los Angeles's biotech reputations: platforms, tools, diagnostics and therapeutics spun out of UCSD, Scripps, Caltech and UCLA.

193
companies
$13.72B
total raised
27
cities

Companies

Sidewinder Therapeutics hero photo
Sidewinder Therapeutics
San Diego, CA

Sidewinder Therapeutics pioneers the next generation of bispecific antibody-drug conjugates (ADCs) to expand the therapeutic window for patients with difficult-to-treat cancers.

Healthcare
Saphlux hero photo
Saphlux
San Diego, CA

Saphlux provides total micro-LED solutions to enable next-generation displays, including AR Micro-LED Displays and Quantum Dot COB Displays.

Industrials
Rybodyn hero photo
Rybodyn
San Diego, CA

RyboDyn is pioneering immunotherapy development by unlocking the dark proteome with its proprietary RyboCypher™ technology to reveal hidden targets and transform biological signals into breakthrough therapies.

Healthcare
The Adversarial Company hero photo
The Adversarial Company
North Hollywood, CA

The Adversarial Company builds AI-native denial and deception systems, including WRAITH, AI software for generating and evaluating camouflage for machine-observed environments.

Defense Technology
Angitia Biopharmaceuticals
Westlake Village, CA

Angitia Biopharmaceuticals is a clinical-stage biotechnology company focused on the discovery and development of innovative therapeutics for serious musculoskeletal diseases.

Healthcare
Eagle Mountain Data Inc hero photo
Eagle Mountain Data Inc
Irvine, CA · Founded 2025 · ~11-50 employees

Eagle Mountain Data provides next-generation infrastructure, including GPU services, storage, and networking, designed for complex AI workloads and real-time responsiveness at the edge.

B2B
Origami Therapeutics, Inc.
San Diego, CA · Founded 2022 · 4 employees

Oral drugs to halt neurodegeneration

Y CombinatorHealthcare
goodfin hero photo
goodfin
Los Angeles, CA · Founded 2022 · 8 employees

Building the next generation of wealth

Y CombinatorFintech
Scanbase hero photo
Scanbase
Los Angeles, CA · Founded 2022 · 10 employees

The API for Diagnostic Test Analysis (COVID-19, FLU, RSV, STD,…

Y CombinatorHealthcare
Primmune Therapeutics
San Diego, CA

Primmune Therapeutics is a clinical-stage biotechnology company focused on developing systemic cancer immunotherapies that activate the immune system in a precise and controlled manner.

Healthcare
Sarmal
La Jolla, CA

Sarmal is developing proprietary single molecule DNA sequencing technology and target detection technology for genomic detection.

Healthcare
VedaBio hero photo
VedaBio
San Diego, CA · Founded 2021 · 30 employees

CRISPR powered Diagnostics with results in minutes.

Y CombinatorHealthcare
Roadrunner AI hero photo
Roadrunner AI
Westlake Village, CA

Roadrunner AI provides a workspace for the search, analysis, and synthesis of scientific literature, purpose-built for the rigor and methods of life sciences, healthcare, and biomedical research.

Healthcare